scholarly journals Assessment of Macular Function in Patients With Non-Vascularized Pigment Epithelial Detachment

2020 ◽  
Author(s):  
Ryo Asaoka ◽  
Tatsuya Inoue ◽  
Tatsuaki Amari ◽  
Kayoko Komatsu ◽  
Motoshi Yamamoto ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Function ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Retinal Sensitivity ◽  
Optical Coherence ◽  
Pigment Epithelial ◽  
Significant Difference

Abstract Non-vascularized pigment epithelial detachments (PED) are usually associated with dry age-related macular degeneration (AMD). In this study, we aimed to investigate the correlation between visual function and morphologic parameters. Seventeen eyes of eleven patients with non-vascularized AMD were enrolled. In addition to conventional optical coherence tomography (OCT), polarization-sensitive optical coherence tomography (PS-OCT) measurements were performed by evaluating the regularity of retinal pigment epithelium (RPE) entropy within the PED area. Retinal sensitivity was measured with MP-3 microperimetry, and retinal sensitivities within (RSin) and outside (RSout) the PED area were calculated. The relationship between OCT parameters and visual function was analyzed. As a result, there was a significant difference between the RSin and RSout (p < 0.001, Wilcoxon signed rank test). Moreover, RSin was significantly related to logMAR VA (p = 0.033, linear mixed model). The regularity of RPE entropy was significantly related to visual acuity and RSin (p = 0.00038, p = 0.031, linear mixed model), although neither the height nor area of PED correlated with visual function. Our results suggest that retinal sensitivity is significantly deteriorated within the PED area and RPE entropy measured with PS-OCT was closely related to visual function in eyes with non-vascularized PED.

scholarly journals Assessment of macular function in patients with non-vascularized pigment epithelial detachment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marie Kitano ◽  
Asahi Fujita ◽  
Ryo Asaoka ◽  
Tatsuya Inoue ◽  
Tatsuaki Amari ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Function ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Retinal Sensitivity ◽  
Optical Coherence ◽  
Pigment Epithelial ◽  
Significant Difference

AbstractNon-vascularized pigment epithelial detachments (PED) are usually associated with dry age-related macular degeneration (AMD). In this study, we aimed to investigate the correlation between visual function and morphologic parameters. Seventeen eyes of eleven patients with non-vascularized AMD were enrolled. In addition to conventional optical coherence tomography (OCT), polarization-sensitive optical coherence tomography (PS-OCT) measurements were performed by evaluating the regularity of retinal pigment epithelium (RPE) entropy within the PED area. Retinal sensitivity was measured with MP-3 microperimetry, and retinal sensitivities within (RSin) and outside (RSout) the PED area were calculated. The relationship between OCT parameters and visual function was analyzed. As a result, there was a significant difference between the RSin and RSout (p < 0.001, Wilcoxon signed rank test). Moreover, RSin was significantly related to logMAR VA (p = 0.033, linear mixed model). The regularity of RPE entropy was significantly related to visual acuity and RSin (p = 0.00038, p = 0.031, linear mixed model), although neither the height nor area of PED correlated with visual function. Our results suggest that retinal sensitivity is significantly deteriorated within the PED area and RPE entropy measured with PS-OCT was closely related to visual function in eyes with non-vascularized PED.

scholarly journals Modern trends in diagnostics and prediction of results of anti-vascular endothelial growth factor therapy of pigment epithelial detachment in neovascular agerelated macular degeneration using deep machine learning method (literature review)

2021 ◽  
Vol 6 (6-1) ◽  
pp. 190-203
Author(s):  
E. V. Kozina ◽  
S. N. Sakhnov ◽  
V. V. Myasnikova ◽  
E. V. Bykova ◽  
L. E. Aksenova
Keyword(s):  
Machine Learning ◽  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Pigment Epithelial Detachment ◽  
Optical Coherence ◽  
Pigment Epithelial ◽  
Anti Vegf

Detachment of the pigment epithelium is the separation of the basement membrane of the retinal pigment epithelium from the inner collagen layer of Bruch’s membrane, which occurs in 80 % of cases in patients with neovascular age-related macular degeneration. The outcome of anti-VEGF therapy for pigment epithelial detachment may be adherence of the pigment epithelium, the formation of pigment epithelium tear, or preservation of the detachment. The pigment epithelium tear of 3–4th degrees can lead to a sharp decrease in visual acuity.Most retrospective studies confi rm the absence of a proven correlation between anatomical and functional outcomes in the treatment of pigment epithelial detachment in cases of maintaining the integrity of the pigment epithelium monolayer, and therefore the main attention of researchers is focused on studying the morphological features of pigment epithelial detachment during therapy with angiogenesis inhibitors. Modern technologies of spectral optical coherence tomography make it possible to evaluate detailed quantitative parameters of pigment epithelium detachment, such as height, width, maximum linear diameter, area, volume and refl ectivity within the detachment.Groups of Russian and foreign authors identify various biomarkers recorded on optical coherence tomography images. Dynamic registration of such biomarkers expands the ability of clinicians to predict morphological changes in pigment epithelial detachment during anti-VEGF therapy, as well as to optimize treatment regimens to prevent complications in the form of pigment epithelium tear leading to a decrease in visual acuity.Modern methods of deep machine learning and the use of neural networks allow achieving higher accuracy in diff erentiating the types of retinal fluids and automating the quantitative determination of fl uid under the pigment epithelium. These technologies allow achieving a high level of compliance with manual expert assessment and increasing the accuracy and speed of predicting morphological results of treatment of pigment epithelium detachments.

Pachychoroid Neovasculopathy; Findings, Diagnosis, and Treatment

2020 ◽  
pp. 112-117
Keyword(s):  
Optical Coherence Tomography ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Current Treatment ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Age Related ◽  
Pachychoroid Neovasculopathy ◽  
Sign Type

Pachychoroid neovasculopathy (PNV) is a novel clinical entity with typical pachychoroid features accompanied by type 1 choroidal neovascularization (CNV). Typical optical coherence tomography finding of the disease is flat irregular pigment epithelial detachments (double layer sign). Type 1 CNV between retinal pigment epithelium and Bruch membrane is seen as a tangled network on optical coherence tomography angiography. Differential diagnosis of PNV from neovascular age-related macular degeneration is especially important because of the different epidemiological, genetic, and therapeutic features of these diseases. Current treatment approaches include intravitreal anti-vascular endothelial growth factor injections and photodynamic therapy.

Optical Coherence Tomography Imaging and Quantitative Assessment for Monitoring Dry Age-related Macular Degeneration

2012 ◽  
Vol 06 (02) ◽  
pp. 72 ◽  
Author(s):  
Albert J Augustin ◽  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Quantitative Assessment ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Analysis Tool ◽  
Optical Coherence ◽  
Analysis Software ◽  
Age Related ◽  
Area And Volume

The purpose of this article is to show the feasibility of the ‘Advanced [retinal pigment epithelium] RPE analysis’ software tool to measure drusen area and volume as well as the area of geographic atrophy (GA) in patients with dry age-related macular degeneration (AMD). The source data from spectral domain optical coherence tomography (SD-OCT) images obtained from three patients with confirmed dry AMD using Cirrus™ HD-OCT (Carl Zeiss Meditec) were re-evaluated with the new software analysis tool Advanced RPE analysis. The area of GA as well as drusen area and volume were measured and analysis of results were presented along with calculated values in two clearly arranged screens. Changes between visits were easily detectable and could be followed over time. Results correlated well with clinical observation. The conclusion reached was that the new Advanced RPE analysis software allows the automated, objective and quantitative assessment of atrophic lesions and drusen. It thus could prove to be useful in determining disease stages as well as prognosis more precisely, and provides the opportunity to monitor the effectiveness of new therapies in clinical trials.

Sign in / Sign up

Export Citation Format

Share Document