scholarly journals Photothermal Therapy via a Gold Nanoparticle-Coated Stent for Treating Stent-Induced Granulation Tissue Formation in the Rat Esophagus

2020 ◽  
Author(s):  
Young Chul Cho ◽  
Jeon Min Kang ◽  
Wooram Park ◽  
Dong-Hyun Kim ◽  
Ji Hoon Shin ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Granulation Tissue ◽  
Stent Placement ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Local Heating ◽  
Metallic Stent ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Group A

Abstract Minimally invasive therapies using stent technology are currently limited by stent-induced granulation tissue formation adjacent to the stent. The effectiveness of photothermal therapy (PTT) using a gold nanoparticle (AuNP)-coated stent for treating stent-induced granulation tissue formation in the rat esophagus was investigated. All experiments were approved by the animal research committee of our institution. An AuNP-coated, self-expandable metallic stent (SEMS) was produced to conduct PTT under near-infrared laser irradiation. Forty rats were randomly divided into four groups (10 rats each). The animals in group A (non-coated SEMS) and group B (AuNP-coated SEMS with local heating at 65°C at 4 weeks) were sacrificed 4 weeks after stent placement. The rats in group C (AuNP-coated SEMS with local heating at 65°C at 4 weeks) and group D (AuNP-coated SEMS with local heating at 65°C at 4 and 8 weeks) were sacrificed 8 weeks after stent placement. The effectiveness of local heating was assessed by histopathology. All procedures were successful in all of the animals. Seven rats were excluded because of stent migration (n = 2) and death (n = 5). Granulation tissue formation-related variables were significantly higher in group A than in groups B-D (all p < 0.05). HSP70 and TUNEL expression were significantly lower in group A than in groups B-D (all p < 0.05). Granulation tissue formation-related variables were significantly higher in group C than in groups B and D (all p < 0.05). PTT using AuNP-coated SEMS successfully treated granulation tissue formation after stent placement in the rat esophagus.

scholarly journals Photothermal therapy via a gold nanoparticle-coated stent for treating stent-induced granulation tissue formation in the rat esophagus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Young Chul Cho ◽  
Jeon Min Kang ◽  
Wooram Park ◽  
Dong-Hyun Kim ◽  
Ji Hoon Shin ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Granulation Tissue ◽  
Stent Placement ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Local Heating ◽  
Metallic Stent ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Group A

AbstractMinimally invasive therapies using stent technology are currently limited by stent-induced granulation tissue formation adjacent to the stent. The effectiveness of photothermal therapy (PTT) using a gold nanoparticle (AuNP)-coated stent for treating stent-induced granulation tissue formation in the rat esophagus was investigated. All experiments were approved by the animal research committee of our institution. An AuNP-coated, self-expandable metallic stent (SEMS) was produced to conduct PTT under near-infrared laser irradiation. Forty rats were randomly divided into four groups (10 rats each). The animals in group A (non-coated SEMS) and group B (AuNP-coated SEMS with local heating at 65 °C at 4 weeks) were sacrificed 4 weeks after stent placement. The rats in group C (AuNP-coated SEMS with local heating at 65 °C at 4 weeks) and group D (AuNP-coated SEMS with local heating at 65 °C at 4 and 8 weeks) were sacrificed 8 weeks after stent placement. The effectiveness of local heating was assessed by histopathology. All procedures were successful in all of the animals. Seven rats were excluded because of stent migration (n = 2) and death (n = 5). Granulation tissue formation-related variables were significantly higher in group A than in groups B–D (all p < 0.05). Heat-shock protein 70 (HSP70) and TUNEL expression were significantly lower in group A than in groups B–D (all p < 0.05). Granulation tissue formation-related variables were significantly higher in group C than in groups B and D (all p < 0.05). PTT using AuNP-coated SEMS successfully treated granulation tissue formation after stent placement in the rat esophagus.

scholarly journals Therapeutic effect of local photothermal heating of gold nanoparticle-coated self-expandable metallic stents for suppressing granulation tissue formation in the mouse colon

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249530
Author(s):  
Yeong-Cheol Heo ◽  
Dong-Kyoon Han ◽  
Min Tae Kim
Keyword(s):  
Therapeutic Effect ◽  
Granulation Tissue ◽  
Stent Placement ◽  
Local Heating ◽  
Tissue Formation ◽  
Sems Placement ◽  
Granulation Tissue Formation ◽  
Mouse Colon ◽  
Group A ◽  
Group B

Purpose To investigate the therapeutic effect of local photothermal (PT) heating on suppression of stent-induced granulation tissue formation in mouse colon. Materials and methods A gold nanoparticle (GNP)-coated self-expandable metallic stent (SEMS) was prepared using a two-step synthesis process for local PT heating under near-infrared laser irradiation. Twenty-four mice were randomly divided into two groups of 12 and subjected to SEMS placement in the colon. Group A received a GNP-coated SEMS without local heating and Group B received a GNP-coated SEMS and underwent local heating at 55°C after SEMS placement. The therapeutic effect of local heating was assessed by comparing the histopathological, immunohistochemical, and endoscopic results. Results Four mice were excluded because of stent migration (n = 3, group B) or death (n = 1, group A). Stent-induced granulation tissue-related variables were significantly lower in group B than in group A (p < 0.001). In vivo endoscopic images, 4 weeks after stent placement, showed granulation tissue formation over the wire mesh in group A and relatively good patency of the stented colon with no definite irregularities in group B. There was more vascular endothelial growth factor (VEGF) positivity in group A than in group B. Conclusion Local PT heating suppresses granulation tissue formation after stent placement in mouse colon.

scholarly journals IN-1233, an ALK-5 Inhibitor: Prevention of Granulation Tissue Formation after Bare Metallic Stent Placement in a Rat Urethral Model

Radiology ◽  
2010 ◽  
Vol 255 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Jin Hyoung Kim ◽  
Ho-Young Song ◽  
Jung-Hoon Park ◽  
Hyun-Jung Yoon ◽  
Hyung Gyu Park ◽  
...  
Keyword(s):  
Granulation Tissue ◽  
Stent Placement ◽  
Metallic Stent ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Alk 5 ◽  
Metallic Stent Placement ◽  
Urethral Model

scholarly journals Comparison of vacuum assisted closure therapy with conventional dressing in the management of necrotizing fasciitis wound

2021 ◽  
Vol 8 (12) ◽  
pp. 3587
Author(s):  
Birbal Kumar ◽  
R. S. Mohil ◽  
Sajith K. Mohan ◽  
Navnik Singh Bhardwaj ◽  
Arush Pasricha ◽  
...  
Keyword(s):  
Necrotizing Fasciitis ◽  
Granulation Tissue ◽  
Skin Grafting ◽  
Tissue Formation ◽  
Vacuum Assisted Closure ◽  
Granulation Tissue Formation ◽  
Vac Therapy ◽  
Control Frequency ◽  
Group A ◽  
Group B

Background: The purpose of our study was to compare the effect of vacuum assisted closure (VAC) therapy and conventional dressings in patients with open wounds due to necrotizing fasciitis (NF) on the basis of healing rate, infection control, frequency of dressing and pain score.Methods: The study evaluated 50 patients admitted with NF requiring surgery over a period      of 18 months.  The patients were randomized to two groups. In group A patients, the wounds were managed with conventional dressings and in group B patients, negative pressure wound therapy (NPWT) was applied. Serial assessment of both groups was done for four weeks. The parameters including size of wound, wound bed, granulation tissue formation, color, amount and odor of exudate, edema, frequency of dressing, re-debridement and pain were monitored and analysed.Results: In our study, patients with NF wounds who underwent VAC therapy had earlier granulation tissue formation, resolution of infection and readiness for skin grafting. The frequency of dressing, requirement of re-debridement, resolution of edema, odor, skin maceration, inflammation around wound and pain significantly reduced in group B (VAC) when compared to conventional dressing group.Conclusions: When compared to the conventional dressing on NF wound, application of VAC helped in early appearance of granulation tissue, significant reduction of inflammation, wound odor, exudate, need for re-debridement, frequency of dressing and pain. Thus, VAC dressing can be considered as a better option in the management of NF wounds.

scholarly journals Surgical outcomes in acute dacryocystitis patients undergoing endonasal endoscopic dacryocystorhinostomy with or without silicone tube intubation

2021 ◽  
Vol 14 (6) ◽  
pp. 844-848
Author(s):  
Bo Yu ◽  
◽  
Jia-Ying Sun ◽  
Qian Ye ◽  
Yun-Hai Tu ◽  
...  
Keyword(s):  
Granulation Tissue ◽  
Tissue Formation ◽  
Success Rates ◽  
Granulation Tissue Formation ◽  
Treatment Groups ◽  
Group A ◽  
Silicone Intubation ◽  
Silicone Tube Intubation ◽  
Group B

AIM: To establish the necessity of silicone tube intubation in acute dacryocystitis (AD) patients undergoing endonasal endoscopic dacryocystorhinostomy (En-DCR). METHODS: Patients presenting with unilateral AD were randomly assigned to two treatment groups. En-DCR procedures were performed following lacrimal abscess formation, with the operation being performed with silicone intubation for patients in group B but not group A. Functional success was defined by an absence of additional AD episodes, no epiphora, and ostium patency as established via endoscopic evaluation or fluorescein irrigation. Operative success rates and demographic variables were compared between treatment groups. RESULTS: In total, 66 patients were analyzed in the present study (33 per group), with complete postoperative data having been successfully collected from 27 and 22 patients in group A and group B, respectively. All patients exhibited complete resolution of acute inflammation. Upon follow-up, granulation tissue was detected around the ostium at higher rates in group B (9/22, 40.9%) relative to group A (4/27, 14.8%). At the 12-month follow-up time point, patients in group A exhibited higher success rates (25/27, 92.6%) relative to patients in group B (20/22, 90.9%), but this difference was not significant. Cases of lacrimal passage reconstruction failure in both groups were attributed to excessive fibrous and/or granulation tissue formation proximal to the intranasal ostium. CONCLUSION: Given that these two operative approaches are associated with similar rates of operative success and in light of differences in granulation tissue formation, cost, and operative duration, these data do not support the routine silicone intubation of AD patients following En-DCR surgery.

scholarly journals EW-7197 eluting nano-fiber covered self-expandable metallic stent to prevent granulation tissue formation in a canine urethral model

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192430 ◽  
Author(s):  
Kichang Han ◽  
Jung-Hoon Park ◽  
Su-Geun Yang ◽  
Deok Hee Lee ◽  
Jiaywei Tsauo ◽  
...  
Keyword(s):  
Granulation Tissue ◽  
Metallic Stent ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Expandable Metallic Stent ◽  
Nano Fiber ◽  
Urethral Model
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