scholarly journals Asymmetric Patterns of Visual Field Loss in Primary Angle Closure Glaucoma, High Tension Glaucoma, and Normal Tension Glaucoma

2021 ◽  
Author(s):  
Junhong Jiang ◽  
Cong Ye ◽  
Cong Zhang ◽  
Wenqing Ye ◽  
Xiaoyan Wang ◽  
...  
Keyword(s):  
Central Region ◽  
Early Stage ◽  
Normal Tension Glaucoma ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Mean Deviation ◽  
Automated Perimetry ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
High Tension

Abstract The data directly comparing the spatial pattern of VF defects between primary angle-closure glaucoma (PACG), high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) is not available. We aim to compare the asymmetric patterns of VF defects in patients with PACG, NTG and HTG across different severity levels. A total of 162 eyes of 114 patients with PACG, 111 eyes of 74 patients with HTG and 148 eyes of 102 patients with NTG were included. VF examinations were performed with standard automated perimetry (HFA, SITA-standard strategy, 24-2), and defects were categorized into 3 stages (early, moderate, and advanced) and each hemifield was divided into 5 regions according to Glaucoma Hemifield Test (GHT). The mean total deviation (TD) of each GHT region was calculated. The relationship between the values of pattern standard deviation (PSD) and mean TD was assessed. In the early stage, nasal region of PACG, central region of HTG and all five regions of NTG in the superior hemifield had significantly worse mean TD than their counterparts in the inferior hemifield. In the moderate stage, three regions of NTG in the superior hemifield had significantly worse mean TD than their inferior counterparts. In the advanced stage, central region of PACG, and central and paracentral regions of HTG in the superior hemifield had significantly worse mean TD than their inferior counterparts. When participants were matched by age, sex and mean deviation, in PACG and HTG eyes, all 5 GHT regions in the superior hemifield had worse mean TD than that that of their inferior-hemifield counterparts; however, the differences were not statistically significant. In NTG eyes, the paracentral, nasal, arcuate 1 and arcuate 2 regions in the superior hemifield had significantly worse mean TDs than their inferior counterparts. The superior hemifield is affected more severely than the inferior hemifield in all 3 subtypes of primary glaucoma. This asymmetric tendency was more pronounced in NTG compared to PACG and HTG.

scholarly journals Intraocular asymmetry of visual field defects in primary angle-closure glaucoma, high-tension glaucoma, and normal-tension glaucoma in a Chinese population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Junhong Jiang ◽  
Cong Ye ◽  
Cong Zhang ◽  
Wenqing Ye ◽  
Xiaoyan Wang ◽  
...  
Keyword(s):  
Visual Field ◽  
Normal Tension Glaucoma ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
High Tension ◽  
Significant Difference ◽  
The Mean ◽  
Severity Levels

AbstractDirect comparison data on spatial patterns of visual field (VF) defects among primary angle-closure glaucoma (PACG), high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) are not available. We aimed to compare the intraocular asymmetry of VF loss among patients with PACG, NTG and HTG across different severity levels. A total of 162 eyes of 114 patients with PACG, 111 eyes of 74 patients with HTG and 148 eyes of 102 patients with NTG were included. VF defects were categorized into 3 stages (early, moderate, and advanced), and each hemifield was divided into 5 regions according to the Glaucoma hemifield test (GHT). The mean total deviation (TD) of each GHT region was calculated. In the early stage, the paracentral, peripheral arcuate 1 and peripheral arcuate 2 regions in the superior hemifield in the NTG group had significantly worse mean TDs than their corresponding regions in the inferior hemifield. In the advanced stage, the central region in the superior hemifield in the PACG group had a significantly worse mean TD than that in the inferior hemifield. There was no significant difference in the mean TD for any of the five regions between hemifields across all severity levels in the in the HTG group. The superior hemifield was affected more severely than the inferior hemifield in all three subtypes of primary glaucoma. This asymmetric tendency was more pronounced in NTG than in PACG and HTG.

Comparison of Saccadic Eye Movements Among the High Tension Glaucoma, Primary Angle Closure Glaucoma, and Normal Tension Glaucoma

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Shonraj Ballae Ganeshrao ◽  
Amina Jaleel ◽  
Sirija Madicharla ◽  
Vanga Kavya Sri ◽  
Juwariah Zakir ◽  
...  
Keyword(s):  
Eye Movements ◽  
Saccadic Eye Movements ◽  
Normal Tension Glaucoma ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
High Tension

scholarly journals Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ruyue Shen ◽  
Yu Meng Wang ◽  
Carol Y. Cheung ◽  
Poemen P. Chan ◽  
Clement C. Tham
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Disease Severity ◽  
Optical Coherence Tomography Angiography ◽  
Normal Tension Glaucoma ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Rnfl Thickness

AbstractTo investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A). One or both eyes of each subject were imaged for a 3 × 3 mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined. Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of 49 control subjects were cross-sectionally analyzed. NTG eyes had significantly lower global cpVD (52.369 ± 0.781%) compared with PACG eyes (55.389 ± 0.721%, P = 0.004) that had comparable disease severity and average RNFL thickness. Multivariable analysis revealed that, for PACG and NTG eyes, decreased cpVD ([PACG] β = −4.242; CI: −8.120, −0.363 vs [NTG] β = −5.531; CI: −9.472, −1.590) and cpFD ([PACG] β = −8.894;CI: −11.925, −5.864 vs [NTG] β = −12.064; CI: −17.095, −6.932) were associated with decreased RNFL thickness (all P ≤ 0.032); with a stronger association between decrease cpFD and decreased RNFL thickness in NTG eyes (P = 0.028). Decreased cpVD was associated with decrease mean deviation (MD) in NTG eyes (β = −0.707; CI: −1.090, −0.324; P ≤ 0.001) and not associated with the visual field parameters in PACG eyes. Early NTG had lower global cpVD compared with early PACG, despite similar disease severity and average RNFL thickness.

scholarly journals Normal Tension Primary Ppen-Angle Glaucoma with Progressive Synechial Angle Closure in Senior Chinese

2021 ◽  
Author(s):  
Zhigang Fan ◽  
Zhenni Zhao ◽  
Xiaowei Yu ◽  
Dandan Zhang ◽  
Nannan Sun ◽  
...  
Keyword(s):  
Anterior Chamber Depth ◽  
Normal Tension Glaucoma ◽  
Angle Closure ◽  
Mean Deviation ◽  
Glaucomatous Optic Neuropathy ◽  
Fiber Layer ◽  
Treatment Targets ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Senior Population

Abstract Background: This study is to address a unique subtype of combined-mechanism glaucoma (CMG), normal tension glaucoma (NTG) with progressive synechial angle closure in the Chinese senior population, whose clinical course and treatment targets are quite different from classic primary angle-closure glaucoma (PACG). Methods: In this retrospective study, 12 patients with NTG plus primary angle closure suspect or primary angle closure were included in the CMG group, and 12 classic PACG patients with matched extent of glaucomatous optic neuropathy (GON) were included in the control (PACG) group. Clinical features and detailed histories of disease development were investigated and compared between these two groups.Results: There were 6 females and 6 males in CMG group, 3 males and 9 females in PACG group. No statistical significances were found in age (63.42 ± 5.90 vs. 59.42 ± 7.47 years), preoperative intraocular pressure (20.75 ± 5.06 vs. 21.25 ± 4.47 mmHg), anterior chamber depth (ACD) (1.98 ± 0.28 vs. 1.94 ± 0.21mm), mean deviation of visual field (24.37 ± 6.54 vs. 22.01 ± 0.85 dB), average retinal nerve fiber layer thickness (48.00 ± 14.00 vs. 57.25 ± 14.10 μm), cup-to-disc (C/D) ratio (0.89 ± 0.07 vs. 0.87 ± 0.07) and axial length (22.69 ± 0.76 vs. 22.47 ± 0.69 mm) between the two groups (P > 0.05). The extent of synechial angle closure in PACG group was more extensive than that in CMG group, as evaluated by the number of “clock hours” (3.96 ± 1.14 vs. 9.38 ± 1.99, P < 0.05), although the severity of GON was comparable.Conclusion: If NTG develops with synechial angle closure, it might be misdiagnosed as PACG. We need to recognize and scrutinize this specific subtype of CMG, which is very common in the Chinese senior population, but widely neglected. In contrast to classic PACG, treatment targets in NTG with progressive synechial angle closure is primarily in consistent with those in NTG.

scholarly journals Optical coherence tomography angiography of the macular retina in primary angle closure glaucoma

2019 ◽  
Author(s):  
Yang Zhang ◽  
Shunhua Zhang ◽  
Chan Wu ◽  
Yao Zhang ◽  
Ailing Bian ◽  
...  
Keyword(s):  
Pearson Correlation ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Control Group ◽  
Mean Deviation ◽  
Case Group ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Abstract Background: To detect the macular vessel density (MVD) changes in primary angle closure glaucoma (PACG) and to investigate the correlation between MVD and other glaucomatous changes. Methods: A case-control study. Eyes of 22 PACG patients with an episode of acute primary angle closure (APAC) in one of the two eyes. Structural OCT scans were used to obtain peripapillary retinal nerve fiber layer (RNFL), macular ganglion cell complex (GCC) thickness and C/D area ration. OCT angiography (OCTA) was used to measure MVD. Results: In the control group, the dense macular blood vessels were visible on OCTA， the macular vessels were sparse in the case group, and with an enlarged fovea avascular zone. There was a reduction in MVD in the case group compared with the controls (P<0.01). No correlations between MVD, VF mean deviation (MD), C/D area ratio, GCC thickness or RNFL thickness were found in the control group. In the case group, the Pearson correlation analysis showed that MVD was significantly correlated with BCVA (r=0,65, P=0.001), GCC (r=0.50, P=0.018) and VF MD (r=-0.54, P=0.009). In the case group, the multiple stepwise regression analysis, in which MVD were considered the dependent variables, showed that BCVA and GCC were significant predictors. Conclusions: Macular microvascular network attenuated and MVD reduced significantly caused by APAC. MVD was strongly linked to BCVA and GCC.

scholarly journals Association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yunhua Loo ◽  
Tin A. Tun ◽  
Eranga N. Vithana ◽  
Shamira A. Perera ◽  
Rahat Husain ◽  
...  
Keyword(s):  
Severe Disease ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Multivariate Logistic Regression Analysis ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Mean Deviation ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Anterior Segment Parameters

AbstractTo investigate the association of peripheral anterior synechiae (PAS) with intraocular pressure (IOP) and anterior-segment parameters in subjects with primary angle-closure glaucoma (PACG). A total of 267 subjects with PACG were recruited and underwent gonioscopy and anterior-segment optical coherence tomography (ASOCT). Customized software was used to measure ASOCT parameters, including angle opening distance (AOD750) and trabecular-iris-space-area (TISA750) at 750 µm from the scleral spur, anterior chamber depth, width, area and volume (ACD, ACW, ACA, ACV), iris thickness (IT750), iris area (IAREA), and lens vault (LV). Presenting IOP was defined as the first IOP reading before the initiation of IOP-lowering treatment. The mean age of the 267 subjects was 67.0 ± 8.9 years, 140 (52.4%) were male, and 246 (92.1%) were of Chinese ethnicity. PAS was present in 122 (45.7%) subjects, and was most frequently found in the superior quadrant (79.5%). Subjects with PAS had greater presenting IOP (28.7 ± 12.9 vs 22.4 ± 9.7 mmHg, p < 0.001), narrower AOD750 (p < 0.001), smaller TISA750 (p < 0.001), ACD (p = 0.04), ACA (p = 0.02), ACV (p = 0.01) and larger LV (p = 0.01) compared to PACG eyes without PAS. No significant differences were noted for iris parameters. A multivariate logistic regression analysis showed that higher presenting IOP (β = 0.20, p < 0.001), worse visual field mean deviation (β = − 0.20, p = 0.01) and narrower AOD750 (β = − 0.25, p = 0.03) were the only parameters that significantly correlated with the extent of PAS in clock hours. Almost one-half of the subjects with PACG demonstrated PAS; these eyes were associated with higher presenting IOP, smaller anterior segment dimensions and more severe disease.

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