scholarly journals A Case of Mucor Irregularis-Associated Cutaneous Mucormycosis in the Forearm

2021 ◽  
Author(s):  
Zeting Wu ◽  
Wenwei Dong ◽  
Liwei Yao ◽  
Dingli Xu ◽  
Xianwu Chen ◽  
...  
Keyword(s):  
Subcutaneous Tissue ◽  
Deep Part ◽  
Left Forearm ◽  
Lesion Site ◽  
Partial Rupture ◽  
Mucor Irregularis ◽  
Cutaneous Mucormycosis ◽  
Dressing Change ◽  
Bean Dregs

Abstract A 61-year-old man developed rupture of the left forearm after cupping 1 year ago, which was partially improved after surgical dressing change. However, the lesion site recurred repeatedly since then and no cure was found. In the recent one month, he came to the hospital for treatment due to the increased area of skin rupture. The lesions involved subcutaneous tissue, reaching deep to the fascia layer, with large black mildew spots on the surface and necrosis like bean dregs in the deep part. The lesion was irregular in distribution, with different sizes and unclear boundaries. Blood blisters and papules could be seen on the skin at the edge, with partial rupture and hemorrhage.

scholarly journals Empyema Necessitans in the Setting of Methicillin-Susceptible Staphylococcus aureus Causing Pneumonia and Bacteremia

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Sindhura Bandaru ◽  
Sukesh Manthri ◽  
Vidya Sundareshan ◽  
Vidhya Prakash
Keyword(s):  
Staphylococcus Aureus ◽  
Chest Wall ◽  
Subcutaneous Tissue ◽  
Parietal Pleura ◽  
Intravenous Drug Use ◽  
Rare Occurrence ◽  
Left Forearm ◽  
Gram Stain ◽  
Incision And Drainage ◽  
Prompt Diagnosis

Empyema necessitans (EN) is a rare phenomenon that refers to an insidious extension of the empyema through parietal pleura and subsequent dissection into subcutaneous tissue of the chest wall. A 29-year-old man presented to the hospital with fever and chills a few days after an inadvertent needle stick while injecting heroin. His left forearm was warm with an area of fluctuance. He underwent incision and drainage of the left forearm abscess with fluid submitted for Gram stain and culture. His condition rapidly deteriorated due to sepsis, and he required transfer to the intensive care unit. A new 4 × 3 cm area over the left pectoralis muscle had become increasingly indurated, fluctuant, and erythematous. CT of the chest demonstrated extensive cavitary lung lesions and a large loculated left-sided pleural effusion with extension through the chest wall. TEE revealed a 3 cm complex lesion on the superior septal leaflet of the tricuspid valve. The patient underwent incision and drainage of the pectoralis major EN with placement of a drain. Blood and sputum cultures grew methicillin-susceptible Staphylococcus aureus (MSSA) at which time antibiotic therapy was tailored to oxacillin. Our case highlights a rare occurrence of EN due to MSSA in a patient with intravenous drug use (IDU) and underscores the importance of prompt diagnosis and treatment.

scholarly journals Taxonomy and epidemiology of Mucor irregularis , agent of chronic cutaneous mucormycosis

2013 ◽  
Vol 30 (1) ◽  
pp. 48-56 ◽  
Author(s):  
X.-L. Lu ◽  
M.J. Najafzadeh ◽  
S. Dolatabadi ◽  
Y.-P. Ran ◽  
A.H.G. Gerrits van den Ende ◽  
...  
Keyword(s):  
Mucor Irregularis ◽  
Cutaneous Mucormycosis

Cutaneous mucormycosis caused by Mucor irregularis in a patient with CARD 9 deficiency

2018 ◽  
Vol 180 (1) ◽  
pp. 213-214 ◽  
Author(s):  
X. Wang ◽  
A. Wang ◽  
X. Wang ◽  
R. Li ◽  
J. Yu
Keyword(s):  
Mucor Irregularis ◽  
Cutaneous Mucormycosis

scholarly journals In vivo and in vitro impairments in T helper cell and neutrophil responses against Mucor irregularis in Card9 knockout mice

2021 ◽  
Author(s):  
Lingyue Sun ◽  
Shuzhen Zhang ◽  
Zhe Wan ◽  
Ruoyu Li ◽  
Jin Yu
Keyword(s):  
Bone Marrow ◽  
T Helper ◽  
Chemokine Production ◽  
Lectin Receptors ◽  
Immunological Mechanisms ◽  
Mucor Irregularis ◽  
Cutaneous Mucormycosis ◽  
Increased Susceptibility

Mucor irregularis is a frequently found fungus in Asia, especially China, and it causes primary cutaneous mucormycosis with a high rate of disfigurement. Caspase recruitment domain-containing protein 9 (Card9) is an essential adaptor molecule downstream of C-type lectin receptors. It mediates the activation of nuclear factor kappa B (NF-κB), regulates T helper (Th)1 and Th17 differentiation and plays an important role in fungal immune surveillance. CARD9 deficiency correlates with the increased susceptibility to many fungal infections, including cutaneous mucormycosis caused by M. irregularis. However, the underlying immunological mechanisms were not elucidated. Our study established a murine model of subcutaneous M. irregularis infection, and we isolated immune cells, including bone marrow-derived macrophages, bone marrow-derived dendritic cells, naïve T cells and neutrophils, from wild-type (WT) and Card9 knockout (Card9-/-) mice to examine the antifungal effect of Card9 on M. irregularis in vivo and in vitro. Card9-/- mice exhibited increased susceptibility to M. irregularis infection. Impaired local cytokine and chemokine production, NF-κB (p65) activation and Th1/17 cell differentiation and partially impaired neutrophil-dependent antifungal immunity were observed in Card9-/- mice. This work enriches our knowledge of the relationship between CARD9 deficiency and mucormycosis.

Successful Treatment by Surgery of a Primary Cutaneous Mucormycosis Caused by Mucor irregularis

2017 ◽  
Vol 183 (2) ◽  
pp. 445-449 ◽  
Author(s):  
Guan-zhao Liang ◽  
Wen-qi Xu ◽  
Xiao-li Zheng ◽  
Huan Mei ◽  
Gui-xia Lv ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Mucor Irregularis ◽  
Cutaneous Mucormycosis ◽  
Primary Cutaneous Mucormycosis

scholarly journals Subcutaneous Aspergillus nodule with cutaneous Enterococcus infection

2021 ◽  
Vol 2021 (9) ◽  
Author(s):  
Makoto Kondo ◽  
Keiichi Yamanaka
Keyword(s):  
Tissue Culture ◽  
Enterococcus Faecalis ◽  
Bacterial Culture ◽  
Subcutaneous Tissue ◽  
Skin Surface ◽  
Deep Infection ◽  
Left Forearm ◽  
Culture Form ◽  
Infectious Organism ◽  
Surface Scale

ABSTRACT An 87-year-old woman presented with a subcutaneous nodule with overlying black and yellow scales on the surface located on the left forearm. Enterococcus faecalis grew up in bacterial culture using specimen from skin surface scale. And Aspergillus fumigatus was detected in the subcutaneous tissue culture. When suspecting a deep infection, not only the surface part but also the deeper part must be cultured, because we may mislead about the identity of the infectious organism only bacterial culture form skin surface.

scholarly journals Mucor irregularis-associated cutaneous mucormycosis: Case report and review

2014 ◽  
Vol 6 ◽  
pp. 62-65 ◽  
Author(s):  
Blandine Rammaert ◽  
Cécile Angebault ◽  
Anne Scemla ◽  
Sylvie Fraitag ◽  
Nathalie Lerolle ◽  
...  
Keyword(s):  
Case Report ◽  
Mucor Irregularis ◽  
Cutaneous Mucormycosis

Great Increase of Numbers of Virus Particles by Irradiating C3H Mouse Mammary Tumors Transplanted into Male Mice

1972 ◽  
Vol 30 ◽  
pp. 272-273
Author(s):  
P. J. Melnick ◽  
J. W. Cha ◽  
E. Samouhos
Keyword(s):  
Subcutaneous Tissue ◽  
Mammary Tumors ◽  
The Body ◽  
X Ray ◽  
Virus Particles ◽  
Mouse Mammary Tumors ◽  
Transplantable Tumors ◽  
C3h Mice ◽  
Cobalt Radiation ◽  
Enzyme Changes

Spontaneous mammary tumors in females of a high tumor strain of C3H mice were cut into small fragments that were Implanted into the subcutaneous tissue of the back of males of the same strain, where they grew as transplantable tumors. When about Cm. In diameter daily fractional radiation was begun, applied to the tumors, the rest of the body being shielded by a lead shield. Two groups were treated with 150 and 200 r X-ray dally, of half value layer 0.6mm. copper; a third group was treated with 500 r cobalt radiation dally. The primary purpose was to examine the enzyme changes during radiation, with histochemlcal technics.

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