scholarly journals Evaluation of High Density Lipoprotein Cholesterol Concentrations among Elderly Ischaemic Stroke Patients

2018 ◽  
Vol 13 (1) ◽  
pp. 8-12
Author(s):  
Kazi Jannat Ara ◽  
Abu Shams Md Hasan Ali Masum ◽  
Md Shafiqus Saleheen ◽  
Sheikh Abdul Kader ◽  
Sk Mahbub Alam ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Ischaemic Stroke ◽  
High Density Lipoprotein Cholesterol ◽  
Heart Diseases ◽  
Smoking Habit ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Stroke Patients ◽  
Female Ratio

Stroke is an alarming health hazard all over the world as well as in Bangladesh and one of the leading causes of mortality and morbidity. There is a well-established inverse relation between serum concentrations of high density lipoprotein cholesterol (HDL-c) and the risk of coronary heart diseases but it is not a welldocumented risk factor for stroke. This study was done to evaluate of the HLD-c concentration among elderly ischaemic stroke patients. This cross sectional study was conducted in Out Patient department (OPD) stroke clinic and Indoor of the department of neurology, BSMMU, Dhaka from July 2015 to June 2016. A total 200 patients suffering from ischaemic stroke within the range of 61-95 years of age of both sexes with TIA, and hemorrhagic stroke were included. Patient with Stoke after one month of onset, cases with anti-lipid drugs were excluded. Male and female ratio was 1.95:1. Mean age was 68.4±8.24 years. 75 (52.8%) patients had hypertension, 20 (14.1%) had diabetes mellitus,10 (7.0%)patients had atrial fibrillation,8(5.6%)had ischemic heart disease. 44 (31.0%) patients had smoking habit ,mean total cholesterol was 190.7±56.0 mg/dl, mean HDL was36.9±8.4mg/dl, mean LDL was123.9±38.8mg/dl and mean Triglyceride was 175.9±70.5 mg/dl. HDL level gradually decreased according to the increment of age. HDL-c is low in elderly ischaemic stroke patient.University Heart Journal Vol. 13, No. 1, January 2017; 8-12

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Stroke Patients ◽  
Apo B ◽  
Lipid Ratios ◽  
Atherosclerotic Stenosis

Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios (all P <0.05) were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for the identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients. Take home message: Several lipid ratios were significantly related to ICAS risk and have several differences between men and women in stroke patients.

COMPARITIVE STUDY OF HDL-C LEVEL IN DIABETIC AND NONDIABETIC STROKE SUBJECTS

1969 ◽  
Vol 6 (2) ◽  
pp. 816-820
Author(s):  
SAHIBZADA SAEED JAN ◽  
AMIN JAN ◽  
JAN.I.ALAM ◽  
TAJ MUHAMMAD KHAN
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Stroke Patients ◽  
History Of

BACKGROUND: Diabetes mellitus is a well recognized risk factor for acute stroke, resulting in agreater ischemic to hemorrhagic stroke ratio in the people with diabetes compared with the generalpopulation. Diabetes also doubles the risk of stroke recurrence and has a poor outcome (or having poorprognosis for survival) as compared to non-diabetic patients, warranting strong and comprehensivepreventive efforts, The aim of this study was to evaluate the High Density Lipoprotein-Cholesterol(HDL-C) level in the adult diabetic and non-diabetic stroke patients coming to Medical Unit of SaiduTeaching Hospital, Swat.MATERIAL AND METHODOLOGY: This was a cross-sectional study, comprised of 100 subjects,50 were diabetic and 50 were non -diabetic stroke patients of ages between 40 to 90 years. The studysubjects underwent a detailed history and examination. Individuals with a history of medications knownto affects body composition, patients on anti-coagulants and having a history of blood dyscrasias likeleukemia’s, thalasemia, polycythemia, endocrinopathies and patients having clotting disorders, extraduraland intradural hemorrhage as a cause of stroke were excluded from the study. Fasting as well as randomblood sample were drawn from the participants for biochemical assays. The serum HDL-C level, bloodsugar (random and fasting), blood pressure (systolic and diastolic) of Diabetic stroke subjects werecompared with Non-diabetic stroke subjects.RESULTS: The HDL-C level was significantly low in our study in diabetic as compared to nondiabetic stroke subjects.CONCLUSION: The low HDL-C level along with poor metabolic control is an important risk factorfor chronic complications of diabetes mellitus like microvascular and macrovascular disease likeunstable angina, myocardial infarction and stroke. Therefore there is intense need of early screening andinterventions, to prevent macrovascular complications especially stroke in high risk diabetic patients.KEY WORDS: Diabetes mellitus, High-density Lipoprotein-Cholesterol (HDL-C), Blood pressure,Stroke.

scholarly journals Association between non-high-density lipoprotein cholesterol and haemorrhagic transformation in patients with acute ischaemic stroke

2019 ◽  
Author(s):  
Yanan Wang ◽  
Quhong Song ◽  
Yajun Cheng ◽  
Chenchen Wei ◽  
Chen Ye ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Ischaemic Stroke ◽  
High Density Lipoprotein Cholesterol ◽  
Acute Ischaemic Stroke ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Predictive Values ◽  
Haemorrhagic Transformation ◽  
Increased Risk

Abstract Background: It is unclear whether non-high-density lipoprotein cholesterol (Non-HDL-C) is associated with haemorrhagic transformation (HT) after acute ischaemic stroke (AIS). We aimed to explore the association between Non-HDL-C and HT, as well as compare predictive values of Non-HDL-C and low-density lipoprotein cholesterol (LDL-C) for HT.Methods: We consecutively enrolled AIS patients within 7 days of stroke onset. Participants were divided into four categories according to quartiles of Non-HDL-C. HT was assessed by follow-up brain imaging. We assessed the association between Non-HDL-C, LDL-C and HT.Results: A total of 2043 patients were included, among whom 232 were identified as HT. Compared with the highest quartiles, the first, second and third quartiles of Non-HDL-C were associated with increased risk of HT (adjusted Odds ratios [ORs] 1.74 [95% Confidence Interval [CI] 1.09-2.78], 2.01[95% CI 1.26-3.20], and 1.76 [95% CI 1.10-2.83], respectively, P for trend=0.024). Similar results were found for LDL-C. There was significant interaction between Non-HDL-C and age (P for interaction=0.021). The addition of Non-HDL-C and LDL-C to conventional factors significantly improved predictive values (Non-HDL-C, net reclassification index [NRI] 0.24, 95%CI 0.17-0.31, P<0.001; LDL-C, NRI 0.15, 95%CI 0.08-0.22, P=0.03).Conclusions: Low Non-HDL-C was associated with increased risks of HT. In addition, Non-HDL-C has similar effects as LDL-C for predicting HT.

scholarly journals Evaluation of monocyte-to-high-density lipoprotein cholesterol ratio and monocyte-to-lymphocyte ratio in ischemic stroke

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052093380
Author(s):  
Huiling Liu ◽  
Feng Zhan ◽  
Yazhou Wang
Keyword(s):  
Ischemic Stroke ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Diagnostic Value ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Stroke Patients ◽  
Cholesterol Ratio ◽  
Lymphocyte Ratio

Objectives We aimed to evaluate the diagnostic value of the combination of the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) with the monocyte-to-lymphocyte ratio (MLR) in ischemic stroke patients. Methods There were 253 patients who were diagnosed with ischemic stroke and 211 healthy subjects enrolled into this retrospective study. Result MHR and MLR were significantly higher in ischemic stroke patients compared with controls. MHR and MLR remained as independent variables for the presence of ischemic stroke. In receiver operating characteristic analyses, the optimal cut-off values for MHR and MLR were 0.28 and 0.19, respectively. The area under the curve for MHR was 0.777 (sensitivity, 66.01%; specificity, 77.25%), and that for MLR was 0.742 (sensitivity, 70.36%; specificity, 67.77%) in ischemic stroke patients. Moreover, the combination MHR and MLR increased the sensitivity compared with MHR or MLR alone. Conclusion The present study shows that a high MHR and MLR are each predictive for the risk of ischemic stroke, and together, they exhibit a better diagnostic value compared with each ratio alone.

scholarly journals Association between non-high-density lipoprotein cholesterol and haemorrhagic transformation in patients with acute ischaemic stroke

2019 ◽  
Author(s):  
Yanan Wang ◽  
Quhong Song ◽  
Yajun Cheng ◽  
Chenchen Wei ◽  
Chen Ye ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Ischaemic Stroke ◽  
High Density Lipoprotein Cholesterol ◽  
Acute Ischaemic Stroke ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Predictive Values ◽  
Haemorrhagic Transformation ◽  
Increased Risk

Abstract Background : It is unclear whether non-high-density lipoprotein cholesterol (Non-HDL-C) is associated with haemorrhagic transformation (HT) after acute ischaemic stroke (AIS). We aimed to explore the association between Non-HDL-C and HT, as well as compare the predictive values of Non-HDL-C and low-density lipoprotein cholesterol (LDL-C) for HT. Methods: We consecutively enrolled AIS patients within 7 days of stroke onset. Participants were divided into four categories according to quartiles of Non-HDL-C. HT was assessed by follow-up brain imaging. We assessed the association between Non-HDL-C, LDL-C and HT in multivariate logistic regression analysis. Results: A total of 2043 patients were included, among whom 232 were identified as HT. Compared with the highest quartiles, the first, second and third quartiles of Non-HDL-C were associated with increased risk of HT (adjusted Odds ratios [ORs] 1.74 [95% Confidence Interval [CI] 1.09-2.78], 2.01[95% CI 1.26-3.20], and 1.76 [95% CI 1.10-2.83], respectively, P for trend=0.024). Similar results were found for LDL-C. There was significant interaction between Non-HDL-C and age ( P for interaction=0.021). The addition of Non-HDL-C and LDL-C to conventional factors significantly improved predictive values (Non-HDL-C, net reclassification index [NRI] 0.24, 95%CI 0.17-0.31, P<0.001; LDL-C, NRI 0.15, 95%CI 0.08-0.22, P=0.03). Conclusions: Low Non-HDL-C was associated with increased risks of HT. In addition, Non-HDL-C has similar effects as LDL-C for predicting HT. Keywords: Non-high-density lipoprotein cholesterol, Haemorrhagic transformation, Acute ischaemic stroke

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Stroke Patients ◽  
Apo B ◽  
Lipid Ratios ◽  
Atherosclerotic Stenosis

Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients. Take home message: Variables that were significantly related to ICAS risk included the TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C, and apo B/apo A-I ratios. Among the variables tested, the apo B/apo A-I ratio showed the best performance in identifying ICAS risk in stroke patients. Besides, several gender differences were observed with regard to other lipid ratios.

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