Central corneal thickness measurements in phakic, pseudophakic, and aphakic children with ultrasound pachymetry and different non-contact devices

Abstract Aims: Evidence for choosing a satisfactory device for central corneal thickness (CCT) measurement in children particularly pseudophakic and aphakic ones is insufficient. The aim of this study is to compare four differently-measured CCTs obtained using ultrasound pachymetry (UP), Pentacam, partial coherence interferometry (PCI), and specular microscopy (SM) in phakic, pseudophakic, and aphakic children and assess the agreement between the six pairs of the methods. Methods: Children with history of cataract surgery at age six or younger and phakic children were recruited into this study. CCT was measured using UP (Optikon 2000, Rome, Italy), Pentacam (Oculus Inc, Wetzlar, Germany), PCI (IOLMaster 700, Carl Zeiss Meditec AG, Jena, Germany), and SM (Topcon SP-3000P; Topcon Corporation, Japan).Results: One-hundred two eyes (53 phakic, 29 pseudophakic, and 20 aphakic eyes) were included. The mean ages (±SD) of phakic, pseudophakic, and aphakic cases were 9.75 (±3.3), 9.9 (±2.3), and 8.2 (±2.8) years respectively. The mean CCTs (±SE) for phakic children using Pentacam, PCI, UP, and SM were 549.7 (±5.0), 546.5 (±4.5), 565.9 (±5.5), and 506.2 (±4.4) mm respectively, for pseudophakic cases were 570.1 (±6.4), 565.0 (±6.1), 571.9 (±6.3), and 524.3 (±6.3) mm respectively, and for aphakic participants were 635.3 (±14.2), 635.4 (±14.5), 649.0 (±13.5), and 589.1 (±13.3) mm respectively. Conclusion: Compared to Pentacam and PCI, SM underestimated CCT particularly in phakic and pseudophakic children, whereas UP slightly overestimated CCT especially in phakic and aphakic children. Furthermore, Pentacam and PCI had the closest agreement. By contrast, SM had the poorest agreement with the other three methods.

Download Full-text

Comparison of ultrasound pachymetry and partial coherence interferometry in the measurement of central corneal thickness

Journal of Cataract & Refractive Surgery ◽

10.1016/s0886-3350(02)01533-x ◽

2002 ◽

Vol 28 (12) ◽

pp. 2142-2145 ◽

Cited By ~ 43

Author(s):

Georg Rainer ◽

Vanessa Petternel ◽

Oliver Findl ◽

Leopold Schmetterer ◽

Christian Skorpik ◽

...

Keyword(s):

Central Corneal Thickness ◽

Corneal Thickness ◽

Partial Coherence ◽

Partial Coherence Interferometry ◽

Ultrasound Pachymetry

Download Full-text

Central corneal thickness measurements with partial coherence interferometry, ultrasound, and the Orbscan system

Ophthalmology ◽

10.1016/j.ophtha.2003.09.027 ◽

2004 ◽

Vol 111 (5) ◽

pp. 875-879 ◽

Cited By ~ 64

Author(s):

Georg Rainer ◽

Oliver Findl ◽

Vanessa Petternel ◽

Barbara Kiss ◽

Wolfgang Drexler ◽

...

Keyword(s):

Central Corneal Thickness ◽

Corneal Thickness ◽

Partial Coherence ◽

Partial Coherence Interferometry ◽

Thickness Measurements

Download Full-text

Corneal thickness and endothelial cell density in diabetic and non- diabetic patients: a hospital based comparative study

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20182125 ◽

2018 ◽

Vol 5 (3) ◽

pp. 694 ◽

Cited By ~ 1

Author(s):

Nagaraj G. ◽

Anasuya Sangaraj Desai ◽

Nagesh Jayaram

Keyword(s):

Endothelial Cell ◽

Cell Density ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Endothelial Cell Density ◽

Diabetic Group ◽

Control Group ◽

Diabetic Patients ◽

Specular Microscopy ◽

The Mean

Background: Diabetes mellitus is associated with structural changes in corneal endothelial cells and their thickness. The present study was done to compare the endothelial cell density (ECD), central corneal thickness (CCT) and morphology in diabetic and non-diabetic patients.Methods: A cross-sectional study was conducted at Minto Ophthalmic hospital, BMC and RI Bangalore for a period of 20 months (October 2013 - May 2015). A total of 200 study subjects, 100 diabetics and 100 non-diabetic age matched controls were selected, and complete timed ophthalmic evaluation was performed. Specular microscopy was performed on all patients for endothelial cell count assessment and corneal thickness was measured by Pachymeter. The data was analyzed and represented using descriptive statistics. ‘t’ test was used for comparing the two groups.Results: The mean endothelial cell density in diabetic group was significantly lower (2438.73±250.23cells/mm2) compared to non-diabetic group (2599.88±168.16cells/mm2) (p<0.0001). The mean Central corneal thickness in diabetic group was significantly higher (518.40±28.13 μm) compared to control group (490.14±24.31 μm) (p<0.001). The Co-efficient of variation percentage of the diabetics was higher than the non-diabetics but this difference was not statistically significant (P>0.05). The hexagonality percentage was significantly lower in diabetic group compared to the controls suggesting less pleomorphism in the diabetic group.Conclusions: The study concludes that the endothelial cell density was lower and central corneal thickness was higher in diabetic patients compared with the non-diabetics. The altered endothelial morphology was significantly seen in the form of pleomorphism (hexagonality) but polymegathism was not significantly altered.

Download Full-text

Corneal Thickness and Endothelial Morphology in Normal Thai Eyes

10.21203/rs.2.21265/v1 ◽

2020 ◽

Author(s):

Napaporn Tananuvat ◽

Natawan Khumchoo

Keyword(s):

Endothelial Cell ◽

Cell Density ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Age Groups ◽

Inverse Correlation ◽

Cell Loss ◽

Endothelial Cell Density ◽

Specular Microscopy ◽

The Mean

Abstract Background: This study aimed to determine the influence of age on central corneal thickness and corneal endothelial morphology as well as to identify the relationship between them in normal Thai eyes.Methods: Non-contact specular microscopy was performed in volunteers stratified into seven age groups ranging from 11-88 years. The corneal endothelial parameters studied included central corneal thickness (CCT), endothelial cell density (ECD), coefficient of variation in cell size (CV), cell area (CA) and percentage of regular hexagonal cells.Results: In a total of 501 subjects (1002 eyes), the mean age was 43.12 ± 18.80 years and 347(69.3%) were females. The mean CCT, ECD, CV, CA, and hexagonality was 533.80 ± 33.00 μm, 2,732±258 cell/mm2, 37.61 ± 6.76%, 369.04 ± 37.90 mm, and 49.03% ± 7.53%, respectively. There was a statistically significant inverse correlation between age and CCT (r = -0.212, P <0.001), ECD (r = -0.484, P <0.001), and hexagonality (r = -0.193, P <0.001). The estimate rate of endothelial cell loss was 0.2% per year, whereas CV and CA had statistically significant correlation with age (r = 0.200, P <0.001 and r = 0.475, P <0.001). CCT correlated directly with ECD (r = 0.177, P <0.001).Conclusion: Normative data for corneal endothelial morphology in healthy Thai eyes showed that ECD, CCT, and hexagonality were significantly decreased, while CV and CA were increased with aging. The central corneal thickness was correlated with the endothelial cell density.

Download Full-text

Comparison of Central Corneal Thickness Measurements between Angiovue Optical Coherence Tomography, Ultrasound Pachymetry and Ocular Biometry

Ophthalmology Research An International Journal ◽

10.9734/or/2020/v13i430172 ◽

2020 ◽

pp. 1-9

Author(s):

E. Pateras ◽

A. I. Kouroupaki

Keyword(s):

Optical Coherence Tomography ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Repeated Measurements ◽

Optical Coherence ◽

Swept Source ◽

Ocular Biometry ◽

Significant Linear Correlation ◽

Ultrasound Pachymetry ◽

The Mean

Purpose: To compare central corneal thickness (CCT) measurements and their reproducibility when taken by Ultrasound Pachymetry, Ocular Biometry and Angiovue Optical Coherence Tomography (OCT). Methods: Twenty-five healthy volunteers were recruited creating a sample size of 50 eyes. All subjects had pachymetric measurements by Ultrasound pachymetry (PachPen Handheld Pachymeter, Keeler Instruments Inc), Ocular biometry (IOL Master 700 Swept Source Biometry, Zeiss) and Angiovue Optical Coherence Tomography (Optovue Avanti RTVue XR Angiovue). The measurements of central corneal thickness for the three devices were taken by the same examiner twice for more accuracy. Results: The average measurements of central corneal thickness by Ultrasound pachymetry (PachPen Handheld Pachymeter, Keeler Instruments Inc), Ocular biometry (IOL Master 700 Swept Source Biometry, Zeiss) and Angiovue Optical Coherence Tomography (Optovue Avanti RTVue XR Angiovue) were 547.26 μm, 551.36 μm, and 536.42 μm, respectively. The mean standard deviation (SD) of repeated measurements by Ocular biometry was 48.87 μm, which was greater than the mean SD of 44.24 μm and 40.35 μm (P < 0.001) by ultrasound pachymetry and Angiovue optical coherence tomography, respectively. There were statistically significant differences in the measurement results among the 3 methods (Ultrasound pachymetry vs. Ocular biometry P = 0.019; Ultrasound pachymetry vs. Angiovue Optical Coherence Tomography; P < 0.001; Ocular biometry vs. Angiovue Optical Coherence Tomography P < 0.001). There was a significant linear correlation between the Ultrasound pachymetry and Ocular biometry (r = 0.945, P<0.001), Ultrasound pachymetry and Angiovue Optical Coherence Tomography (r = 0.895, P<0.001), and Ocular biometry and Angiovue Optical Coherence Tomography (r = 0.902, P<0.001). Conclusion: Central corneal thickness readings were comparable between PachPen Handheld Pachymeter, IOL Master 700 Biometry and Angiovue Optical Coherence Tomography; Angiovue optical coherence tomography gave significantly smaller values. The measurements of the 3 methods showed significant linear correlations with one another. All methods provided acceptable repeatability of measurements.

Download Full-text