Comparison between planar and single-photon emission computed tomography images for radiation intensity quantification in iodine-131 scintigraphy

2021 ◽  
Author(s):  
Yusuke Iizuka ◽  
Tomohiro Katagiri ◽  
Minoru Inoue ◽  
Kiyonao Nakamura ◽  
Takashi Mizowaki
Keyword(s):  
Radiation Dose ◽  
Single Photon ◽  
Photon Emission ◽  
Correlation Coefficients ◽  
Emission Computed Tomography ◽  
Planar Images ◽  
Iodine 131 ◽  
The Mean ◽  
Photon Emission Computed Tomography ◽  
Spect Images

Abstract This study aimed to evaluate the feasibility of quantifying iodine-131 (131I) accumulation in scintigraphy images and compare planar and single-photon emission computed tomography (SPECT) images to estimate 131I radioactivity in patients receiving radioactive iodine therapy for thyroid cancer. We evaluated 72 sets of planar and SPECT images acquired between February 2017 and December 2018. Simultaneously, we placed a reference 131I capsule next to the patient during image acquisition. We evaluated the correlation between the intensity of the capsule in the images and the capsule dose and estimated the radiation dose at the thyroid bed. The mean capsule dose was 2.14 MBq (range, 0.63–4.31 MBq). The correlation coefficients (p-value) between capsule dose and maximum and mean intensities in both planar and SPECT images were 0.93 (p < 0.01), 0.96 (p < 0.01), 0.60 (p < 0.01), and 0.47 (p < 0.01), respectively. The mean intensities of planar images show the highest correlation coefficients. Based on a regression equation, the average radiation dose in the thyroid bed was 5.9 MBq. In conclusion, planar images reflected the radiation dose more accurately than SPECT images. The regression equation allows to determine the dose in other regions, such as the thyroid bed or sites of distant metastasis.

scholarly journals Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yusuke Iizuka ◽  
Tomohiro Katagiri ◽  
Minoru Inoue ◽  
Kiyonao Nakamura ◽  
Takashi Mizowaki
Keyword(s):  
Computed Tomography ◽  
Radiation Dose ◽  
Single Photon ◽  
Correlation Coefficients ◽  
Regression Equation ◽  
Emission Computed Tomography ◽  
Planar Images ◽  
Iodine 131 ◽  
The Mean ◽  
Spect Images

AbstractThis study aimed to evaluate the feasibility of quantifying iodine-131 (131I) accumulation in scintigraphy images and compare planar and single-photon emission computed tomography (SPECT) images to estimate 131I radioactivity in patients receiving radioactive iodine therapy for thyroid cancer. We evaluated 72 sets of planar and SPECT images acquired between February 2017 and December 2018. Simultaneously, we placed a reference 131I capsule next to the patient during image acquisition. We evaluated the correlation between the intensity of the capsule in the images and the capsule dose and estimated the radiation dose at the thyroid bed. The mean capsule dose was 2.14 MBq (range, 0.63–4.31 MBq). The correlation coefficients (p-value) between capsule dose and maximum and mean intensities in both planar and SPECT images were 0.93 (p < 0.01), 0.96 (p < 0.01), 0.60 (p < 0.01), and 0.47 (p < 0.01), respectively. The mean intensities of planar images show the highest correlation coefficients. Based on a regression equation, the average radiation dose in the thyroid bed was 5.9 MBq. In conclusion, planar images reflected the radiation dose more accurately than SPECT images. The regression equation allows to determine the dose in other regions, such as the thyroid bed or sites of distant metastasis.

scholarly journals Radioiodination and Purification of [131I]β-CIT and [131I]FP-CIT with an Automated Radiosynthesizer

2022 ◽  
Vol 15 (1) ◽  
pp. 96
Author(s):  
Elisabeth Plhak ◽  
Edith Gößnitzer ◽  
Reingard M. Aigner ◽  
Herbert Kvaternik
Keyword(s):  
Solid Phase ◽  
Single Photon ◽  
Photon Emission ◽  
Tropane Alkaloids ◽  
Radiochemical Yield ◽  
Emission Computed Tomography ◽  
Dopaminergic Dysfunction ◽  
Free Iodine ◽  
Iodine 131 ◽  
Photon Emission Computed Tomography

Dopaminergic transporter (DAT) imaging with single photon emission computed tomography (SPECT) is used to diagnose Parkinson’s disease and to differentiate it from other neurodegenerative disorders without presynaptic dopaminergic dysfunction. The radioiodinated tropane alkaloids [123I]FP-CIT and [123I]β-CIT enable the evaluation of the integrity of DATs. Commonly, the labeling of these compounds is performed by electrophilic substitution of the alkylstannylated precursors with radioactive iodine and following purification by HPLC or solid phase extraction (SPE). This work presents the first radioiodination of β-CIT and FP-CIT with no carrier added [131I]NaI on a Scintomics GRP synthesis module. Free iodine-131 and impurities were removed by SPE over a C-18 Sep-Pak cartridge. We achieved a radiochemical yield of >75% and a radiochemical purity of >98% with both compounds. Our development of an automated synthesis on a commercially available synthesizer ensures robust and efficient labeling of [131I]FP-CIT and [131I]β-CIT starting with low concentrated radioiodine.

scholarly journals Detecting Synchronous Parathyroid Adenoma and False-Positive Findings on Technetium-99m MIBI Single Photon-Emission Computed Tomography/Computed Tomography

Diagnostics ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 57
Author(s):  
Ji Lee ◽  
Hee-Sung Song ◽  
Jae Choi ◽  
Chang Hyun ◽  
Sang Lee ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Thyroid Disease ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Planar Images ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography ◽  
Mibi Spect

Technetium (Tc)-99m-methoxyisobutylisonitrile (MIBI) single photon-emission computed tomography/computed tomography (SPECT/CT) is now being used increasingly for preoperative localization of parathyroid adenomas. Tc-99m-MIBI scintigraphy in a 52-year-old man with a diagnosis of primary hyperparathyroidism revealed two focal areas with retention of radioactivity in the left lobe of the thyroid gland on the delayed phase of MIBI SPECT/CT but no significant focal radioactive uptake on MIBI planar images. The patient subsequently underwent left partial parathyroidectomy. Histological analysis identified one lesion to be thyroid hyperplasia and the other to be parathyroid adenoma. This case demonstrates the value of MIBI SPECT/CT for localization of a parathyroid lesion when compared with planar images and that false-positive findings can lead to misdiagnosis in a patient with coexisting thyroid disease. An appropriate diagnostic work-up that includes Tc-99m MIBI SPECT/CT in addition to ultrasonography is helpful for an accurate diagnosis in patients with concomitant thyroid disease.

scholarly journals Estimation of Cerebral Perfusion Reserve by Blood Oxygenation Level—Dependent Imaging: Comparison with Single-Photon Emission Computed Tomography

2003 ◽  
Vol 23 (1) ◽  
pp. 121-135 ◽  
Author(s):  
Akihiko Shiino ◽  
Yasuo Morita ◽  
Atsushi Tsuji ◽  
Kengo Maeda ◽  
Ryuta Ito ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Blood Oxygenation ◽  
Reserve Capacity ◽  
Emission Computed Tomography ◽  
Cerebrovascular Reserve ◽  
Oxygenation Level ◽  
The Mean ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Measurement of cerebrovascular reserve capacity predicts the risk of ischemic insult in patients with major vessel occlusion. Blood oxygenation level-dependent (BOLD) imaging has the potential to estimate reserve capacity of the cerebral circulation noninvasively based on changes in the signal that reflect differences in the magnetic susceptibility of intravascular oxyhemoglobin and deoxyhemoglobin. The authors examined the feasibility of using the BOLD technique to assess cerebrovascular reserve capacity in patients with cerebrovascular occlusive disease by comparing results with an established method of measuring CBF. Ten patients with severe or complete occlusion of the internal carotid artery were compared with 17 healthy subjects to evaluate regional differences and identify variables that indicate a change in the BOLD signal. Dilation of cerebral vessels was induced by breath holding, and the R2* change was examined with gradient-echo, echo-planar imaging. Before measuring the regional change in the BOLD signal, actual timing of “activated” and “rest” periods was corrected by shifting the phase of a sine-wave template to obtain the largest correlation coefficient. Percent signal change was calculated on a pixel-by-pixel basis and was compared with CBF measured by single-photon emission computed tomography (SPECT) before and after acetazolamide challenge. The degree of impairment and the distribution of impaired areas detected by the BOLD study correlated with the results of SPECT. Overall sensitivity and specificity of the BOLD technique by visual inspection were 100% and 98.4%, respectively. A negative response (decreased CBF) frequently was observed in areas of exhausted reserve capacity, suggesting that a “steal” phenomenon exists. The percent change and the ΔCBF were well correlated ( P < 0.01). The mean percent change in most areas of impaired reserve capacity was more than 2 SD below the mean values in healthy subjects. The present method of semiquantitative BOLD analysis can be used to create a map of the cerebral hemodynamic state. Furthermore, the development of reliable, generally accessible techniques for evaluating cerebral hemodynamics opens the door for clinical studies to monitor and treat patients with compromised reserve. This study is an attempt to develop such analysis.

scholarly journals Comparison of Bone Single-Photon Emission Computed Tomography (SPECT)/CT and Bone Scintigraphy in Assessing Knee Joints

2020 ◽  
Author(s):  
Young-Sil An ◽  
Do Young Park ◽  
Byoung-Hyun Min ◽  
Joon-Kee Yoon
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Ct Images ◽  
Knee Joints ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Planar Images ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Abstract Background: This study attempted to compare the radiopharmaceutical uptake findings of planar bone scintigraphy (BS) and single photon emission computed tomography (SPECT)/computed tomography (CT) performed on knee joints.Methods: We retrospectively included 104 patients who underwent bone SPECT/CT and BS 4 hours after the intravenous administration of technetium-99m-hydroxymethylene diphosphonate (99mTc-HDP) for pain in the knee joint. The uptake degree of each of the knee regions (medial femoral, lateral femoral, medial tibial, lateral tibial, and patellar area) in planar images and SPECT/CT were evaluated by visual (grades 0 to 2) and quantitative analyses (uptake counts for planar image and standardized uptake values [SUVs] for SPECT/CT). Results: The uptake grades assessed visually on the planar images differed significantly from the uptake grades on SPECT/CT images in all areas of the knee (all p < 0.001), and SPECT/CT imaging revealed a larger number of uptake lesions than those noted in planar imaging for each patient (3.3 ± 2.0 versus 2.4 ± 2.3, p < 0.0001). In all regions of the knee, all of the quantitative values, including uptake counts obtained from the planar image as well as the maximum SUV (SUVmax) and mean SUV (SUVmean) obtained from SPECT/CT, showed statistically higher values as their visual grades increased (all p <0.001). However, when analyzed for each area, only the SUVmax showed a significant difference by grade in all knee regions. Quantitative uptake values obtained from planar images were moderately correlated with SUVs of SPECT/CT images (r = 0.58 for SUVmean and r = 0.53 for SUVmax, all p <0.001) in the total knee regions. Looking at each area, there was a significant but low correlation between the uptake counts of the planar images and the SUVs on SPECT/CT in the right lateral tibial region (r = 0.45 for SUVmean, r = 0.31 for SUVmax, all p <0.001).Conclusions: In assessing knee joints, the findings of planar images and SPECT/CT images differ both visually and quantitatively, and more lesions can be found in SPECT/CT than in the planar images.

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