scholarly journals Quantity of Relaxin Receptors in the Ligament of Head of Femur in Infants with Developmental Hip Dysplasia

2021 ◽  
Author(s):  
Semih Ayanoglu ◽  
Haluk Çabuk ◽  
Fatmagül Kuşku Çabuk ◽  
Kubilay Beng ◽  
Timur Yıldırım ◽  
...  
Keyword(s):  
Risk Factor ◽  
Hip Dysplasia ◽  
Ligamentum Teres ◽  
Control Group ◽  
Developmental Hip Dysplasia ◽  
Clinical Prognosis ◽  
Prospective Comparative Study ◽  
Relaxin 2 ◽  
Level 2

Abstract BackgroundDevelopmental dysplasia of hip (DDH) etiology is still a controversial issue. While many factors involved in the etiology, one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the physiological nature of the ligament, as well as by long-term exposure to relaxin during pregnancy. Our objective in this study was to determine the quantity of relaxin receptors in the ligamentum teres and their part in causing DDH.MethodsWe identified infants between birth and 3 years of age who had undergone open reduction for DDH between 2010 and 2012. 12 hips of 12 miss abortus fetus between 20 to 35 weeks of gestation were used as control group. Specimens obtained from two groups were stained with Relaxin-2 antibody and the amount of staining for relaxin receptors was determined using an ordinal H score. ResultsThe mean H scores of infants with DDH were significantly higher than those of controls (p=0.00). ConclusionAs a result, increased number of relaxin receptors in the ligamentum teres could be a risk factor for DDH and the number of relaxin receptors is an important clue in explaining the female:male ratio and clinical prognosis of early dysplastic hips.Level of Evidence: Level 2, Prospective comparative study

scholarly journals Are Hips Too Relaxed to Develop Healthy ?

2021 ◽  
Author(s):  
Semih Ayanoglu ◽  
Haluk Çabuk ◽  
Fatmagül Kuşku Çabuk ◽  
Kubilay Beng ◽  
Timur Yıldırım ◽  
...  
Keyword(s):  
Ligamentum Teres ◽  
Developmental Dysplasia ◽  
Control Group ◽  
Level Of Evidence ◽  
Clinical Prognosis ◽  
Developmental Dysplasia Of Hip ◽  
Prospective Comparative Study ◽  
The Mean ◽  
Relaxin 2

Abstract Background: Developmental dysplasia of hip (DDH) etiology is still a controversial issue. While many factors involved in the etiology, one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the physiological nature of the ligament, as well as by long-term exposure to relaxin during pregnancy. Our objective in this study was to determine the quantity of relaxin receptors in the ligamentum teres and their part in causing DDH.Methods: We identified infants between birth and 3 years of age who had undergone open reduction for DDH between 2010 and 2012. 12 hips of 12 miss abortus fetus between 20 to 35 weeks of gestation were used as control group. Specimens obtained from two groups were stained with Relaxin-2 antibody and the amount of staining for relaxin receptors was determined using an ordinal H score. Results: The mean H scores of infants with DDH were significantly higher than those of controls (p=0.00). Conclusion: As a result, increased number of relaxin receptors in the ligamentum teres could be a risk factor for DDH and the number of relaxin receptors is an important clue in explaining the female:male ratio and clinical prognosis of early dysplastic hips.Level of Evidence: Level 2, Prospective comparative study

scholarly journals Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Semih Ayanoğlu ◽  
Haluk Çabuk ◽  
Fatmagül Kuşku Çabuk ◽  
Kubilay Beng ◽  
Timur Yildirim ◽  
...  
Keyword(s):  
Open Reduction ◽  
Ligamentum Teres ◽  
Developmental Dysplasia ◽  
Control Group ◽  
Level Of Evidence ◽  
Significant Difference ◽  
Prospective Comparative Study ◽  
Relaxin 2 ◽  
Dysplasia Of The Hip

Abstract Background While many factors involved in the etiology of developmental dysplasia of the hip (DDH), one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the physiological nature of the ligament, as well as by long-term exposure to relaxin during pregnancy. Our objective in this study was to determine the number of relaxin receptors in the ligamentum teres and their role in causing DDH. Methods We identified 26 infants between birth and 3 years of age who had undergone open reduction for DDH between 2010 and 2012. 12 hips of 12 miss abortus fetus between 20 to 35 weeks of gestation were used as control group. Specimens obtained from two groups were stained with Relaxin-2 antibody, and the amount of staining for relaxin receptors was determined using an ordinal H score. Results The mean (SD) H scores of infants with DDH were significantly higher than those of controls: 215 (59) versus 52 (48); P = 0.00; 95% CI. Statistically significant difference between the two groups in terms of gender was not found. Conclusion As a result, increased number of relaxin receptors in the ligamentum teres could be a risk factor for DDH. Level of evidence Level 2, Prospective comparative study.

Long-Term Results of Bulk Femoral Head Autograft in Cementless THA for Developmental Hip Dysplasia

Orthopedics ◽  
2011 ◽  
Vol 34 (2) ◽  
Author(s):  
Shu Saito ◽  
Takao Ishii ◽  
Sei Mori ◽  
Kunihiro Hosaka ◽  
Naho Nemoto ◽  
...  
Keyword(s):  
Femoral Head ◽  
Hip Dysplasia ◽  
Long Term Results ◽  
Developmental Hip Dysplasia

MODULUS Stem for Developmental Hip Dysplasia: Long-term Follow-up

2015 ◽  
Vol 30 (10) ◽  
pp. 1747-1751 ◽  
Author(s):  
Francesco M. Benazzo ◽  
Lucio Piovani ◽  
Alberto Combi ◽  
Loris Perticarini
Keyword(s):  
Hip Dysplasia ◽  
Developmental Hip Dysplasia ◽  
Long Term Follow Up

scholarly journals The Ilizarov technology for closed reduction of hip dislocation in children with developmental hip dysplasia

2021 ◽  
Vol 27 (3) ◽  
pp. 345-350
Author(s):  
M.P. Teplenky ◽  
◽  
E.V. Oleinikov ◽  
V.S. Bunov ◽  
◽  
...  
Keyword(s):  
Closed Reduction ◽  
Functional Outcomes ◽  
Hip Dysplasia ◽  
Hip Dislocation ◽  
Treatment Method ◽  
Long Term Results ◽  
Aseptic Necrosis ◽  
Developmental Hip Dysplasia

Introduction The possibility of gradual closed reduction of hip dislocation in children over 1.5 years old is considered doubtful. Purpose Analysis of long-term results of applying the Ilizarov technique of gradual closed reduction in combination with the reconstruction of the hip joint components. Methods The outcomes of treatment of 62 children (81 joints) with congenital hip dislocation in the follow-up period from 5 to 16 years were studied. The treatment method included closed reduction of the dislocation using the technology proposed by G.A. Ilizarov and subsequent reconstruction of the joint components. The patients are divided into two groups based on their age. The first group included 33 patients (43 joints) under the age of 5 years. The second group consisted of 29 patients (38 joints) aged 5–8 years. Results Closed reduction failed in five cases. The recurrence of dislocation after closed reduction was 5.3 %. The rate of aseptic necrosis after closed reduction was 9.7 %. Good functional outcomes were reported in 87.7 %. They were significantly better in the younger group. The proportion of good anatomical results did not depend on age and was 77 % in general. Poor results were obtained in 8.8 %. Conclusion The anatomical and functional outcomes and the number of complications by using the technique described were comparable to other methods of gradual closed reduction of hip dislocation. But the technique we have described expands the age restrictions for its use.

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