scholarly journals Exosome-associated mitochondrial DNA from patients with ME/CFS stimulates human cultured microglia to release IL-1β

2021 ◽  
Author(s):  
Irene Tsilioni ◽  
Benjamin Natelson ◽  
Theoharis C. Theoharides
Keyword(s):  
Mitochondrial Dna ◽  
Sleep Disturbances ◽  
Serum Levels ◽  
Chronic Fatigue ◽  
Human Microglia ◽  
Fatigue Syndrome ◽  
Pathogenetic Factor ◽  
Significant Release ◽  
Cognitive Problems ◽  
Potential Biomarkers

Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease that presents with fatigue, sleep disturbances, malaise and cognitive problems. The pathogenesis of ME/CFS is presently unknown and serum levels of potential biomarkers have been inconsistent. Here we show that serum mitochondrial DNA (mtDNA), associated with exosomes, is increased in ME/CFS only after exercise. Moreover, exosomes isolated from patients with ME/CFS stimulate significant release of IL-1β from cultured human microglia. These results provide evidence for a potential novel pathogenetic factor and target for treatment of ME/CFS.

scholarly journals Exosome-associated Mitochondrial DNA is Elevated in Patients with ME/CFS and Stimulates Human Cultured Microglia to Secrete IL-1β

2021 ◽  
Author(s):  
Theoharis C Theoharides ◽  
Irene Tsilioni ◽  
Benjamin Natelson
Keyword(s):  
Mitochondrial Dna ◽  
Sleep Disturbances ◽  
Serum Levels ◽  
Chronic Fatigue ◽  
Human Microglia ◽  
Fatigue Syndrome ◽  
Before And After ◽  
Pathogenetic Factor ◽  
Cognitive Problems ◽  
Potential Biomarkers

Abstract Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease that presents with fatigue, sleep disturbances, malaise and cognitive problems. The pathogenesis of ME/CFS is presently unknown and serum levels of potential biomarkers have been inconsistent. Methods: Exosomes were purified from serum obtained from patients with ME/CFS before and after exercise and their content of mitochondrial DNA (mtDNA) was determined by quantitative PCR. Exosomes from both patients and controls were incubated with cultured human microglia and release of interleukin-1beta (IL-1β) was measured by ELISA.Results: Here we show that serum mtDNA, associated with exosomes, is increased in ME/CFS after exercise. Moreover, exosomes isolated from patients with ME/CFS stimulate significant secretion of IL-1β from cultured human microglia. Conclusion: These results provide evidence for a potential novel pathogenetic factor and target for treatment of ME/CFS.

scholarly journals COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review

2021 ◽  
Vol 8 ◽  
pp. 204993612110093
Author(s):  
Sonia Poenaru ◽  
Sara J. Abdallah ◽  
Vicente Corrales-Medina ◽  
Juthaporn Cowan
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Sleep Disturbances ◽  
Q Fever ◽  
Orthostatic Intolerance ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Exercise Intolerance ◽  
Laboratory Findings ◽  
Fatigue Syndrome ◽  
Post Infectious

Coronavirus disease 2019 (COVID-19) is a viral infection which can cause a variety of respiratory, gastrointestinal, and vascular symptoms. The acute illness phase generally lasts no more than 2–3 weeks. However, there is increasing evidence that a proportion of COVID-19 patients experience a prolonged convalescence and continue to have symptoms lasting several months after the initial infection. A variety of chronic symptoms have been reported including fatigue, dyspnea, myalgia, exercise intolerance, sleep disturbances, difficulty concentrating, anxiety, fever, headache, malaise, and vertigo. These symptoms are similar to those seen in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a chronic multi-system illness characterized by profound fatigue, sleep disturbances, neurocognitive changes, orthostatic intolerance, and post-exertional malaise. ME/CFS symptoms are exacerbated by exercise or stress and occur in the absence of any significant clinical or laboratory findings. The pathology of ME/CFS is not known: it is thought to be multifactorial, resulting from the dysregulation of multiple systems in response to a particular trigger. Although not exclusively considered a post-infectious entity, ME/CFS has been associated with several infectious agents including Epstein–Barr Virus, Q fever, influenza, and other coronaviruses. There are important similarities between post-acute COVID-19 symptoms and ME/CFS. However, there is currently insufficient evidence to establish COVID-19 as an infectious trigger for ME/CFS. Further research is required to determine the natural history of this condition, as well as to define risk factors, prevalence, and possible interventional strategies.

Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome

1995 ◽  
Vol 4 (4) ◽  
pp. 751-754 ◽  
Author(s):  
Chunfang Zhang ◽  
Alessandra Baumer ◽  
Ian R. Mackay ◽  
Anthony W. Linnane ◽  
Phillip Nagley
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Unusual Pattern ◽  
Adult Human ◽  
Fatigue Syndrome ◽  
Dna Deletions

scholarly journals Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study

2018 ◽  
Vol 7 (1) ◽  
pp. 1453730 ◽  
Author(s):  
Jesús Castro-Marrero ◽  
Esther Serrano-Pertierra ◽  
Myriam Oliveira-Rodríguez ◽  
Maria Cleofé Zaragozá ◽  
Alba Martínez-Martínez ◽  
...  
Keyword(s):  
Pilot Study ◽  
Chronic Fatigue Syndrome ◽  
Extracellular Vesicles ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome ◽  
Potential Biomarkers

scholarly journals Post-COVID Chronic Fatigue Syndrome: New Challenge Ahead

2021 ◽  
Vol 6 (3) ◽  
pp. 472-478
Author(s):  
Adwitiya Ray ◽  
Neharika Saini ◽  
Ravi Parkash
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Sleep Disturbances ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Exercise Intolerance ◽  
Multiple Systems ◽  
Fatigue Syndrome ◽  
History Of ◽  
Illness Phase ◽  
Post Infectious

Coronavirus disease 2019 (COVID-19) is a viral infection that causes various respiratory, gastrointestinal, and vascular symptoms. The acute illness phase lasts for about 2-3 weeks. However, there is increasing evidence that a percentage of COVID-19 patients continue to experience long-lasting symptoms characterized by fatigue, dyspnea, myalgia, exercise intolerance, and sleep disturbances, difficulty concentrating, anxiety, fever, headache, malaise, and vertigo. Similar symptoms are reported by patients who having myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS). ME/CFS pathology is not known: it is thought to be multifactorial, resulting from the dysregulation of multiple systems in response to a particular trigger. There is a resemblance between post-acute COVID-19 symptoms and ME/CFS. However, at present, there is inadequate evidence to establish COVID-19 as an infectious trigger for ME/CFS. Further research is required to determine the natural history of this condition, as well as to define risk factors, prevalence, and possible interventional strategies. Keywords: chronic fatigue syndrome, COVID-19, human coronavirus, myalgic encephalomyelitis, post-infectious fatigue, review.

scholarly journals Chronic Fatigue Syndrome

2021 ◽  
Vol 18 ◽  
pp. 17-23
Author(s):  
B. Sue Graves ◽  
Sigourney Kame
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Support Groups ◽  
Sleep Disturbances ◽  
Exercise Program ◽  
Chronic Fatigue ◽  
Medical Professional ◽  
Mental Wellbeing ◽  
Fatigue Syndrome ◽  
Patient Feedback ◽  
Persistent Fatigue

Chronic fatigue syndrome is an enduring disease, characterized by a level of persistent fatigue for 6 months or a longer time period. At this time, the etiology is unknown. The other symptoms individuals effected by chronic fatigue syndrome, may experience are sore throat, headaches, impaired cognition, depression, sleep disturbances, and many others. While the diagnosis of chronic fatigue syndrome can be challenging, the Center for Disease Control (CDC) has a set of guidelines to help characterize the presence of this condition in patients. Chronic fatigue syndrome has far-reaching consequences impacting an individual’s physical and mental wellbeing. The best approach in helping these individuals to still engage in physical activity is through gentle, lowlevel exercise program with the use of patient feedback to individualize the treatment as well as providing guidance and support through support groups and therapy as prescribed by a medical professional.

scholarly journals Impact of Life Stressors on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Symptoms: An Australian Longitudinal Study

2021 ◽  
Vol 18 (20) ◽  
pp. 10614
Author(s):  
Cassandra Balinas ◽  
Natalie Eaton-Fitch ◽  
Rebekah Maksoud ◽  
Donald Staines ◽  
Sonya Marshall-Gradisnik
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Support Services ◽  
Sleep Disturbances ◽  
Orthostatic Intolerance ◽  
Living Arrangement ◽  
Chronic Fatigue ◽  
Access To Healthcare ◽  
Myalgic Encephalomyelitis ◽  
Life Stressors ◽  
Fatigue Syndrome

(1) Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multifaceted illness. The pathomechanism, severity and progression of this illness is still being investigated. Stressors have been implicated in symptom exacerbation for ME/CFS, however, there is limited information for an Australian ME/CFS cohort. The aim of this study was to assess the potential effect of life stressors including changes in work, income, or family scenario on symptom severity in an Australian ME/CFS cohort over five months; (2) Methods: Australian residents with ME/CFS responded to questions relating to work, income, living arrangement, access to healthcare and support services as well as symptoms experienced; (3) Results: thirty-six ME/CFS patients (age: 41.25 ± 12.14) completed all questionnaires (response rate 83.7%). Muscle pain and weakness, orthostatic intolerance and intolerance to extreme temperatures were experienced and fluctuated over time. Sleep disturbances were likely to present as severe. Work and household income were associated with worsened cognitive, gastrointestinal, body pain and sleep symptoms. Increased access to healthcare services was associated with improved symptom presentation; (4) Conclusions: life stressors such as work and financial disruptions may significantly contribute to exacerbation of ME/CFS symptoms. Access to support services correlates with lower symptom scores.

scholarly journals Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

2011 ◽  
Vol 9 (1) ◽  
pp. 81 ◽  
Author(s):  
Ekua W Brenu ◽  
Mieke L van Driel ◽  
Don R Staines ◽  
Kevin J Ashton ◽  
Sandra B Ramos ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome ◽  
Immunological Abnormalities ◽  
Potential Biomarkers
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