Systemic lupus erythematosus in a male patient in lower Assam

Systemic lupus erythematosus (SLE) is one of the numerous diseases called “the great imitators” because it frequently resembles or is misdiagnosed as other illnesses. SLE is a chronic autoimmune inflammatory disorder that affects multiple systems and has a wide range of symptoms. The female to male ratio varies between 7 and 15 to 1. A number of observations point to an estrogen impact as the cause of this variance. Because sex hormonal impacts are likely to be modest in youngsters, the female to male ratio is 3:1. Renal involvement and seizures are more common in male SLE patients than photophobia and cutaneous symptoms. Males likewise appear to have a more devastating consequence. As a result, we feel that male lupus patients are uncommon, the illness’s symptoms are life-threatening, and that early discovery of the disease will result in a better outcome for these patients. Here, we report the case of SLE with an unusual presentation in a 44-year-old man from lower Assam to emphasize the importance of a high index of suspicion in such patients.

PAX2 Mutation-Related Renal Hypodysplasia: Review of the Literature and Three Case Reports

Paired box 2 (PAX2)-related disorder is an autosomal dominant genetic disorder associated with kidney and eye abnormalities and can result in end stage renal disease (ESRD). Despite reported low prevalence of PAX2 mutations, the prevalence of PAX2 related disorders may have been underestimated in past studies. With improved genetic sequencing techniques, more genetic abnormalities are being detected than ever before. Here, we report three patients from two families with PAX2 mutations identified within 1 year. Two patients were adults with chronic kidney disease and were followed for decades without correct diagnoses, including one with ESRD who had even undergone kidney transplant. The third patient was a neonate in whom PAX2-related disorder manifested as oligohydramnios, coloboma, and renal failure that progressed to ESRD within 1 year after birth. The phenotypes of PAX2 gene mutation were shown to be highly variable, even within the same family. Early detection promoted genetic counseling and guided clinical management. The appropriate time point for genetic study is an important issue. Clinicians must be more alert for PAX2 mutation when facing patients with congenital kidney and urinary tract anomalies, chronic kidney disease of unknown etiology, involvement of multiple systems, and/or a family history of renal disease.

Ferroelectric-based synapses and neurons for neuromorphic computing

The shift towards a distributed computing paradigm, where multiple systems acquire and elaborate data in real-time, leads to challenges that must be met. In particular, it is becoming increasingly essential to compute on the edge of the network, close to the sensor collecting data. The requirements of a system operating on the edge are very tight: power efficiency, low area occupation, fast response times, and on-line learning. Brain-inspired architectures such as Spiking Neural Networks (SNNs) use artificial neurons and synapses that simultaneously perform low-latency computation and internal-state storage with very low power consumption. Still, they mainly rely on standard complementary metal-oxide-semiconductor (CMOS) technologies, making SNNs unfit to meet the aforementioned constraints. Recently, emerging technologies such as memristive devices have been investigated to flank CMOS technology and overcome edge computing systems' power and memory constraints. In this review, we will focus on ferroelectric technology. Thanks to its CMOS-compatible fabrication process and extreme energy efficiency, ferroelectric devices are rapidly affirming themselves as one of the most promising technology for neuromorphic computing. Therefore, we will discuss their role in emulating neural and synaptic behaviors in an area and power-efficient way.

Eclipsing Binaries in Dynamically Interacting Close, Multiple Systems

Close, compact, hierarchical, and multiple stellar systems, i.e., multiples having an outer orbital period from months to a few years, comprise a small but continuously growing group of the triple and multiple star zoo. Many of them consist of at least one eclipsing pair of stars and, therefore, exhibit readily observable short-term dynamical interactions among the components. Thus, their dynamical and astrophysical properties can be explored with high precision. In this paper we present an overview of the history of the search for additional components around eclipsing binaries from the first serendipitous discoveries to more systematic recent studies. We describe the different observational detection methods and discuss their connections to the different kinds of astrophysical and dynamical information that can be mined from different datasets. Moreover, the connection amongst the observable phenomena and the long-term dynamics of such systems is also discussed.

Cardiovascular Disease, Cancer and Multimorbidity Interactions: Clinical Implications

Background: With the aging population, the frequency of cardiovascular disease (CVD), cancer and other morbid conditions are increasing dramatically. In addition, one disease may affect the other leading to a vicious cycle. Summary: With aging, the function of organs and systems of the human body decline including the autoimmune system resulting in a diminished response to various pathogens and a chronic inflammatory process; these changes, in addition to other risk factors, contributes to the development of multiple morbid conditions including CVD and cancer. Multimorbidity in the elderly has become the rule rather than the exception today. Further, this association between CVD and cancer, at least partially, is explained by both diseases sharing common risk factors and from accelerated vascular aging due to cancer and its associated therapies. Multiple studies have shown that the incidence of cancer is much higher in patients with CVD compared to the general population. These associations among CVD, cancer and their connection to systems of the human body provide an opportunity for novel therapies. Development of new drugs should be addressed to focus on multiple systems and not just only to one disease. Further, collecting information from registries and processing large amounts of data using artificial intelligence may assist the clinician when treating an individual patient in the future. Key messages: As the aging population increases, CVD, cancer and multimorbidity will continue to constitute a major health problem in the years to come. The physician who is taking care of such a patient, in addition to knowledge, requires clinical wisdom, clinical experience and common sense in order to apply the continuous evolving knowledge to the individual patient.

A semiotic analysis of multiple systems of logic: using tagmemic theory to assess the usefulness and limitations of formal logics, and to produce a mathematical lattice model including multiple systems of logic

Tagmemic theory as a semiotic theory can be used to analyze multiple systems of logic and to assess their strengths and weaknesses. This analysis constitutes an application of semiotics and also a contribution to understanding of the nature of logic within the context of human meaning. Each system of logic is best adapted to represent one portion of human rationality. Acknowledging this correlation between systems and their targets helps explain the usefulness of more than one system. Among these systems, the two-valued system of classical logic takes its place. All the systems of logic can be incorporated into a complex mathematical model that has a place for each system and that represents a larger whole in human reasoning. The model can represent why tight formal systems of logic can be applied in some contexts with great success, but in other contexts are not directly applicable. The result suggests that human reasoning is innately richer than any one formal system of logic.

Threat and Risk Assessment Using Continuous Logic

Threat and Risk Assessment is an important area in cybersecurity. It covers multiple systems and organizations where cybersecurity is significant, such as banking, industry, SCADA, Energy Management System, among many others. The chapter presents a method to help assessing threats and risks associated with computer and networks systems. It integrates the Framework for Improving Critical Infrastructure Cybersecurity—developed by the National Institute of Standards and Technology—with a quantitative method based on the use of a Continuous Logic, the Logic Scoring of Preference (LSP) method. LSP is a method suitable for decision making that provides the guidelines to produce a model to assist the expert in the process of assessing how much a product or system satisfy a number of requirements, in this case associated to the identification, protection, detection, response and recovery of threat and risks in an organization.

Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City

Introduction: Several reports have emerged describing the long-term consequences of COVID-19 and its effects on multiple systems. Methods: As further research is needed, we conducted a longitudinal observational study to report the prevalence and associated risk factors of the long-term health consequences of COVID-19 by symptom clusters in patients discharged from the Temporary COVID-19 Hospital (TCH) in Mexico City. Self-reported clinical symptom data were collected via telephone calls over 90 days post-discharge. Among 4670 patients, we identified 45 symptoms across eight symptom clusters (neurological; mood disorders; systemic; respiratory; musculoskeletal; ear, nose, and throat; dermatological; and gastrointestinal). Results: We observed that the neurological, dermatological, and mood disorder symptom clusters persisted in >30% of patients at 90 days post-discharge. Although most symptoms decreased in frequency between day 30 and 90, alopecia and the dermatological symptom cluster significantly increased ( p < 0.00001). Women were more prone than men to develop long-term symptoms, and invasive mechanical ventilation also increased the frequency of symptoms at 30 days post-discharge. Conclusion: Overall, we observed that symptoms often persisted regardless of disease severity. We hope these findings will help promote public health strategies that ensure equity in the access to solutions focused on the long-term consequences of COVID-19.

Effectiveness of Zr(IV)-Loaded Banana Peels Biomass for the Uptake of Fluoride Anion from Water

The present study reports the fluoride uptake potential of Zr(IV)-loaded saponified banana peels (Zr(IV)-SBP) from water. Zr(IV)-SBP was synthesized by loading Zr(IV) onto banana peel biomass after saponification and sorbent characterization was performed by using different techniques including FE-SEM (Field Emission Scanning Electron Microscopy), FTIR (Fourier Transform Infra-Red) spectroscopy and zeta potential analysis. Batch experiments were carried out to examine the monitoring factors for the uptake of fluoride onto the investigated adsorbent. The optimal pH and contact time were found to be 2.94 and 300 minutes, respectively. The results from characterization techniques concurred that Zr(IV)-SBP have prominent adsorption sites favorable for the sorption of fluoride ions. The sorption behavior of fluoride onto Zr(IV)-SBP was best fitted with the Langmuir adsorption isotherm and pseudo-second-order kinetics model. The maximum adsorption capacity of Zr(IV)-SBP was 36.02 mg/g using the Langmuir isotherm model. The coexisting ions like chloride and nitrate caused very small interference, elevated concentration of sulphate notably lowers the fluoride adsorption percentage in the binary system, and the sorption using multiple systems was lowered significantly which is due to the synergistic effect of co-existing interfering ion. The adsorbed fluoride was completely desorbed using 2M NaOH solution. Fluoride sorption performance of Zr(IV)-SBP demonstrated that it can be a low cost, environmentally benign and one of the highly potent alternatives for the remediation of fluoride ions to avoid ablation on the water.