scholarly journals Freestyle Aortic Root Prosthesis in Combination with Aortic Replacement and Open Anastomosis: A Retrospective Analysis.

2021 ◽  
Author(s):  
Alicja Zientara ◽  
Kim Rosselet-Droux ◽  
Hans Bruijnen ◽  
Dragan Odavic ◽  
Michele Genoni ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Aortic Root ◽  
Cerebral Perfusion ◽  
Ascending Aorta ◽  
Categorical Variables ◽  
Moderate Hypothermia ◽  
Aortic Replacement ◽  
Antegrade Cerebral Perfusion ◽  
Open Arch

Abstract Background: The Freestyle® bioprosthesis is used for pathologies of the aortic root. Additional resection of the ascending aorta and the proximal arch in dissections or aneurysms might be indicated. The aim was to assess mid-term outcome regarding prosthetic performance, stroke, reoperations, and survival in various pathologies comparing patients with and without additional procedures on the ascending aorta and proximal arch focusing on the standardized technique of unilateral antegrade cerebral perfusion under moderate hypothermia. Methods: Retrospective data analysis of 278 consecutive patients after Freestyle® root replacement between September 2007 and March 2017. Patients were divided in three categories due to the pathology of the aortic root (re-operation vs endocarditis vs dissection). Two groups based on the aortic anastomosis technique (non-open arch anastomosis (non-OA) versus open arch anastomosis (OA)) were compared (119 OA vs 159 non-OA). Cardiovascular risk, previous cardiac events, intra- and postoperative data were evaluated. Inferential statistics were performed with Mann-Whitney U-test. Nominal and categorical variables were tested with Fisher-Freeman-Halton exact test. Kaplan-Meier estimate was used to assess survival.Results: The follow-up rate was 90% (median follow-up: 39.5 months). There were differences in the indication (endocarditis: OA 5 (4.2%) vs non-OA 36 (24%), p<0.0001; dissection: OA 13 (10.9%) vs non-OA 2 (1.3%); p=0.0007). OA patients had less perioperative stroke (1 (1%) vs 15 (10%), p=0.001) and shorter hospital stay (9 vs 12 days, p=0.0004). There were no differences in the mortality (in-hospital: non-OA 8 (5%) vs OA 8 (7%); p=0.6; death at follow-up: non-OA 15 (11%) vs OA 5 (5%); p=0.1). Overall valve performance showed a well-functioning valve in 97.3% at follow-up.Conclusion: The valve performance showed excellent results regardless of the initial indication. The incidence of stroke was lower in patients receiving an open arch anastomosis using unilateral antegrade cerebral perfusion without elevated mortality or prolonged hospital stay.

scholarly journals Freestyle aortic root prosthesis in combination with aortic replacement and open anastomosis: a retrospective analysis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Alicja Zientara ◽  
Kim Rosselet-Droux ◽  
Hans Bruijnen ◽  
Dragan Odavic ◽  
Michele Genoni ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Aortic Root ◽  
Cerebral Perfusion ◽  
Ascending Aorta ◽  
Categorical Variables ◽  
Moderate Hypothermia ◽  
Aortic Replacement ◽  
Antegrade Cerebral Perfusion ◽  
Open Arch

Abstract Background The Freestyle® bioprosthesis is used for pathologies of the aortic root. Additional resection of the ascending aorta and the proximal arch in dissections or aneurysms might be indicated. The aim was to assess mid-term outcome regarding prosthetic performance, stroke, reoperations, and survival in various pathologies comparing patients with and without additional procedures on the ascending aorta and proximal arch focusing on the standardised technique of unilateral antegrade cerebral perfusion under moderate hypothermia. Methods Retrospective data analysis of 278 consecutive patients after Freestyle® root replacement between September 2007 and March 2017. Patients were divided in three categories due to the pathology of the aortic root (re-operation vs endocarditis vs dissection). Two groups based on the aortic anastomosis technique (open arch anastomosis (OA) versus non-open arch anastomosis (non-OA) were compared (119 OA vs 159 non-OA). Cardiovascular risk, previous cardiac events, intra- and postoperative data were evaluated. Inferential statistics were performed with Mann-Whitney U-test. Nominal and categorical variables were tested with Fisher-Freeman-Halton exact test. Kaplan-Meier estimate was used to assess survival. Results The follow-up rate was 90% (median follow-up: 39.5 months). There were differences in the indication (endocarditis: OA 5 (4.2%) vs non-OA 36 (24%), p < 0.0001; dissection: OA 13 (10.9%) vs non-OA 2 (1.3%); p = 0.0007). OA patients had less perioperative stroke (1 (1%) vs 15 (10%), p = 0.001) and shorter hospital stay (9 vs 12 days, p = 0.0004). There were no differences in the mortality (in-hospital: OA 8 (7%) vs non-OA 8 (5%); p = 0.6; death at follow-up: OA 5 (5%) vs non-OA 15 (11%); p = 0.1). Overall valve performance showed a well-functioning valve in 97.3% at follow-up. Conclusion The valve performance showed excellent results regardless of the initial indication. The incidence of stroke was lower in patients receiving an open arch anastomosis using unilateral antegrade cerebral perfusion without elevated mortality or prolonged hospital stay.

Surgical treatment of the ascending aorta and aortic arch with antegrade cerebral perfusion and moderate hypothermia]]>

2006 ◽  
Vol 21 (4) ◽  
Author(s):  
Marcelo S. S. Martins ◽  
Mauro P. L. S� ◽  
Leonardo Abad ◽  
Eduardo S. Bastos ◽  
Ney Franklin Junior ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Aortic Arch ◽  
Cerebral Perfusion ◽  
Ascending Aorta ◽  
Moderate Hypothermia ◽  
Antegrade Cerebral Perfusion

scholarly journals The use of innominate artery cannulation for antegrade cerebral perfusion in aortic dissection

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Eden C. Payabyab ◽  
Jonathan M. Hemli ◽  
Allan Mattia ◽  
Alex Kremers ◽  
Sohrab K. Vatsia ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Aortic Root ◽  
Cerebral Perfusion ◽  
Innominate Artery ◽  
Type A ◽  
Ascending Aorta ◽  
Aortic Root Replacement ◽  
Artery Cannulation ◽  
Selective Antegrade Cerebral Perfusion ◽  
Antegrade Cerebral Perfusion

Abstract Background Direct cannulation of the innominate artery for selective antegrade cerebral perfusion has been shown to be safe in elective proximal aortic reconstructions. We sought to evaluate the safety of this technique in acute aortic dissection. Methods A multi-institutional retrospective review was undertaken of patients who underwent proximal aortic reconstruction for Stanford type A dissection between 2006 and 2016. Those patients who had direct innominate artery cannulation for selective antegrade cerebral perfusion were selected for analysis. Results Seventy-five patients underwent innominate artery cannulation for ACP for Stanford Type A Dissections. Isolated replacement of the ascending aorta was performed in 36 patients (48.0%), concomitant aortic root replacement was required in 35 patients (46.7%), of whom 7 had a valve-sparing aortic root replacement, ascending aorta and arch replacement was required in 4 patients (5%). Other procedures included frozen elephant trunk (n = 11 (14.7%)), coronary artery bypass grafting (n = 20 (26.7%)), and peripheral arterial bypass (n = 4 (5.3%)). Mean hypothermic circulatory arrest time was 19 ± 13 min. Thirty-day mortality was 14.7% (n = 11). Perioperative stroke occurred in 7 patients (9.3%). Conclusions This study is the first comprehensive review of direct innominate artery cannulation through median sternotomy for selective antegrade cerebral perfusion in aortic dissection. Our experience suggests that this strategy is a safe and effective technique compared to other reported methods of cannulation and cerebral protection for delivering selective antegrade cerebral perfusion in these cases.

scholarly journals The Use of Innominate Artery Cannulation for Antegrade Cerebral Perfusion in Aortic Dissection

2020 ◽  
Author(s):  
Eden C Payabyab ◽  
Jonathan M. Hemli ◽  
Allan Mattia ◽  
Alex Kremers ◽  
Sohrab K. Vatsia ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Aortic Root ◽  
Cerebral Perfusion ◽  
Innominate Artery ◽  
Type A ◽  
Ascending Aorta ◽  
Aortic Root Replacement ◽  
Artery Cannulation ◽  
Selective Antegrade Cerebral Perfusion ◽  
Antegrade Cerebral Perfusion

Abstract Background: Direct cannulation of the innominate artery for selective antegrade cerebral perfusion has been shown to be safe in elective proximal aortic reconstructions. We sought to evaluate the safety of this technique in acute aortic dissection. Methods: A multi-institutional retrospective review was undertaken of patients who underwent proximal aortic reconstruction for Stanford type A dissection between 2006 and 2016. Those patients who had direct innominate artery cannulation for selective antegrade cerebral perfusion were selected for analysis. Results: Seventy-five patients underwent innominate artery cannulation for ACP for Stanford Type A Dissections. Isolated replacement of the ascending aorta was performed in 36 patients (48.0%), concomitant aortic root replacement was required in 35 patients (46.7%), of whom 7 had a valve-sparing aortic root replacement, ascending aorta and arch replacement was required in 4 patients (5%). Other procedures included frozen elephant trunk (n = 11 (14.7%)), coronary artery bypass grafting (n = 20 (26.7%)), and peripheral arterial bypass (n = 4 (5.3%)). Mean hypothermic circulatory arrest time was 19 ± 13 minutes. Thirty-day mortality was 14.7% (n = 11). Perioperative stroke occurred in 7 patients (9.3%).Conclusions: This study is the first comprehensive review of direct innominate artery cannulation through median sternotomy for selective antegrade cerebral perfusion in aortic dissection. Our experience suggests that this strategy is a safe and effective technique compared to other reported methods of cannulation and cerebral protection for delivering selective antegrade cerebral perfusion in these cases.

scholarly journals Direct cannulation of arch vessels for total arch replacement

2017 ◽  
Vol 3 ◽  
pp. 205555201668975
Author(s):  
Yuichi Matsuzaki ◽  
Touitsu Hirayama ◽  
Hideyuki Uesugi ◽  
Ichiro Ideta ◽  
Takashi Oshitomi
Keyword(s):  
Cerebral Perfusion ◽  
Patient Characteristics ◽  
Total Arch Replacement ◽  
Moderate Hypothermia ◽  
Systemic Hypothermia ◽  
Perfusion Time ◽  
Selective Antegrade Cerebral Perfusion ◽  
Antegrade Cerebral Perfusion ◽  
Neurologic Findings

Objectives: To observe the efficiency and safety of direct and indirect three arch vessels’ cannulation for bilateral antegrade cerebral perfusion during total arch replacement. Methods: Between 2002 and 2014, 130 patients underwent total arch replacement with direct and 66 patients with indirect cannulation for antegrade cerebral perfusion under moderate hypothermia. Patients were assigned to the direct cannulation group based on the condition of the aortic arch vessels. Demographics and concomitant surgeries were similar in the two groups. Patient characteristics, surgical and haemodynamic measurements, and postoperative neurologic findings were observed. Results: Aortic cross-clamping (120 ± 42 vs 139 ± 65 min; p = 0.032) and cardiopulmonary bypass (178 ± 57 vs 206 ± 71 min; p = 0.025) times were lower in the direct cannulation group. There were no differences in overall hospital mortality (4% vs 6%; p = 0.87), selective antegrade cerebral perfusion time (91 ± 52 vs 100 ± 65 min; p = 0.185), and incidence of neurologic deficit (3% vs 9%; p = 0.07). Indirect cannulation led to more frequent re-exploration for bleeding (5% vs 13%; p = 0.0356). There was no difference in midterm survival (log-rank p = 0.103; mean follow-up times: 4.74 years (direct cannulation), 5.50 years (indirect cannulation)). Conclusion: Direct cannulation during mild systemic hypothermia yields excellent outcomes while reducing time and rate of reoperation for bleeding and can be used in total arch replacement without increasing morbidity and mortality.

Early outcome and mid-term survival after open arch repair using selective antegrade cerebral perfusion

2021 ◽  
pp. 021849232110287
Author(s):  
Luca Di Marco ◽  
Marianna Berardi ◽  
Giacomo Murana ◽  
Alessandro Leone ◽  
Luca Botta ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Aortic Arch ◽  
Cerebral Perfusion ◽  
Cerebral Protection ◽  
Neurological Dysfunction ◽  
Term Survival ◽  
Early Outcome ◽  
Selective Antegrade Cerebral Perfusion ◽  
Antegrade Cerebral Perfusion ◽  
Open Arch

Objectives The introduction of selective antegrade cerebral perfusion technique as method of cerebral protection improved the outcome of open arch surgery. The aim of this study was to report early outcomes using this technique. Methods Between 1997 and 2017, data were collected retrospectively for all patients who underwent surgical replacement of the aortic arch using selective antegrade cerebral perfusion ( n = 938). To confirm the effectiveness of this cerebral protection method, early outcome and results were evaluated. Results The incidence of postoperative permanent neurological dysfunction was 6.4%. Overall hospital mortality was 11.9% ( n = 112). On multivariable analysis, age >75 years, female gender, euroscore at increment of 1 point, chronic renal failure, extension of thoracic aorta replacement and CPB time emerged as independent risk factors for hospital mortality. The mid-term survival at 1, 5, 10 and 15 years was 92%, 78%, 60% and 49%, respectively. The competing risk analysis for permanent neurological dysfunction and aortic reoperations was performed excluding the patients who died during the hospital stay. The cumulative incidence of permanent neurological dysfunction and aortic reoperations was 2% at 3 years, 3% at 5 years, 6% at 10 years, 12% at 3 years, 15% at 5 years and 19% at 10 years, respectively. Conclusions From the early 90s to the present day, the selective antegrade cerebral perfusion has confirmed to be a useful and “safe” method of brain protection in aortic arch surgery in terms of postoperative neurological complications.

scholarly journals Increased aortic root diameters in patients with acromegaly

2008 ◽  
Vol 159 (2) ◽  
pp. 97-103 ◽  
Author(s):  
Agatha A van der Klaauw ◽  
Jeroen J Bax ◽  
Johannes W A Smit ◽  
Eduard R Holman ◽  
Victoria Delgado ◽  
...  
Keyword(s):  
Aortic Root ◽  
Clinical Manifestations ◽  
Left Ventricular ◽  
Ascending Aorta ◽  
Inactive Disease ◽  
Valvular Regurgitation ◽  
Healthy Controls ◽  
Aortic Sinus ◽  
Sinotubular Junction

ObjectiveThe clinical manifestations of acromegalic cardiomyopathy include arrhythmias, valvular regurgitation, concentric left ventricular (LV) hypertrophy, and LV systolic and diastolic dysfunction. At present, it is unknown whether acromegaly also affects the aortic root.DesignAortic root diameters were prospectively assessed in 37 acromegalic patients (18 patients with active disease and 19 with controlled disease) by conventional two-dimensional and Doppler echocardiography before, and after, an observation period of 1.9 years (range 1.5–3.0 years). Baseline parameters were compared with healthy controls.ResultsThe diameters of the aortic root at the sino-tubular junction and the ascending aorta were increased in patients with acromegaly: 30±4 vs 26±3 mm (P=0.0001) and 33±5 vs 30±4 mm (P=0.006) respectively. The diameter of the aortic root at the aortic annulus and aortic sinus were not different from controls. During follow-up, the aortic root diameters increased at the levels of the annulus and the sinotubular junction (P=0.025 and P=0.024 respectively), whereas there was no change in the diameters at the levels of the sinus and the ascending aorta during follow-up. Baseline aortic root diameters were not influenced by disease duration, current disease activity, or blood pressure. When patients with active and inactive disease were analyzed separately, only the diameter of the sinotubular junction increased in patients with inactive acromegaly during follow-up (P=0.031).ConclusionAortic root diameters are increased in patients with acromegaly compared with healthy controls.

Acute Type A Dissection: Impact of Antegrade Cerebral Perfusion Under Moderate Hypothermia

2013 ◽  
Vol 96 (6) ◽  
pp. 2135-2141 ◽  
Author(s):  
George M. Comas ◽  
Bradley G. Leshnower ◽  
Michael E. Halkos ◽  
Vinod H. Thourani ◽  
John D. Puskas ◽  
...  
Keyword(s):  
Cerebral Perfusion ◽  
Type A ◽  
Moderate Hypothermia ◽  
Acute Type ◽  
Acute Type A Dissection ◽  
Type A Dissection ◽  
Antegrade Cerebral Perfusion

scholarly journals Surgical Aortic Arch Intervention at the time of Extended Ascending Aortic Replacement is Associated with Increased Mortality

2021 ◽  
Author(s):  
Michael Bowdish ◽  
Daniel Logsdon ◽  
Ramsey Elsayed ◽  
Wendy Mack ◽  
Brittany Abt ◽  
...  
Keyword(s):  
Aortic Arch ◽  
Ascending Aorta ◽  
Conservative Approach ◽  
Factors Associated ◽  
Aortic Replacement ◽  
Ascending Aortic Replacement ◽  
Aortic Arch Repair ◽  
Multivariable Models ◽  
Patch Technique

Objective: To compare outcomes of hemiarch versus total arch repair during extended ascending aortic replacement. Methods: Between 2004 and 2017, 261 patients underwent hemiarch (n=149, 57%) or total arch repair (aortic debranching or Carrell patch technique, n=112, 43%) in the setting of extended replacement of the ascending aorta. Median follow-up was 17.2 (IQR 4.2–39.1) months. Multivariable models considering preoperative and intraoperative factors associated with mortality and aortic reintervention were constructed. Results: Survival was 89.0, 81.3, and 73.5% vs. 76.4, 69.5, and 61.7% at 1, 3, and 5 years in the hemiarch versus total arch groups, respectively (log-rank p=0.010). After adjustment for preoperative and intraoperative factors, the presence of a total arch repair (adjusted HR 2.53, 95% CI 1.39 – 4.62, p=0.003), and increasing age (adjusted HR per 10 years of age, 1.76, 95% CI 1.37 – 2.28, p<0.001) were associated with increased mortality. The cumulative incidence of aortic reintervention with death as a competing outcome was 2.6, 2.6, and 4.4% and 5.0, 10.3, and 11.9% in the hemiarch and total arch groups, respectively. After adjustment, the presence of a total arch repair was significantly associated with need for aortic reintervention (SHR 3.21, 95% CI 1.01 – 10.2, p=0.047). Conclusions: Overall survival after aortic arch repair in the setting of extended ascending aortic replacement is excellent, however, total arch repair and increasing age are associated with higher mortality and reintervention rates. A conservative approach to aortic arch repair can be prudent, especially in those of advanced age.

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