scholarly journals The Effect of SOCS2 Polymorphisms on Type 2 Diabetes Mellitus Susceptibility and Diabetic Complications in the Chinese Han Population

2020 ◽  
Author(s):  
Juan Pan ◽  
Rui Tong ◽  
Qing Deng ◽  
Yanni Tian ◽  
Ning Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Complications ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Reduced Risk

Abstract Propose: We explored the effect of SOCS2 polymorphisms on the development of type 2 diabetes mellitus (T2DM) and diabetic complications.Methods: The subjects consisted of 500 T2DM patients and 501 healthy volunteers. Five variants in SOCS2 were genotyped by Agena MassARRAY system. Logistic regression analysis was utilized to calculate the odds ratio (OR) and 95% confidence intervals (95% CI).Results: Rs3825199 (OR = 1.44, p = 0.007), rs11107116 (OR = 1.39, p = 0.014) and rs10492321 (OR = 1.48, p = 0.004) had the increased T2DM risk. Moreover, the contribution of SOCS2 polymorphisms to T2DM risk was associated with age, gender, smoking and drinking and BMI. SOCS2 variants also had the reduced risk for T2DM patients with diabetic nephropathy, diabetic retinopathy and coronary heart disease.Conclusions: This study firstly reported that rs3825199, rs11107116 and rs10492321 in SOCS2 conferred to the increased risk for T2DM occurrence in the Chinese Han population.

scholarly journals Association of IL-16 gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

2019 ◽  
Vol 39 (8) ◽  
Author(s):  
Fangxiao Cheng ◽  
Lu Liu ◽  
Hongli Zhang ◽  
Yi Zhu ◽  
Xiaohua Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chinese Han Population ◽  
Case Group ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk

Abstract Objective: The aim of the present study was to explore the genetic association of single nucleotide polymorphisms (SNPs) in interleukin-16 (IL-16) gene with type 2 diabetes mellitus (T2DM) susceptibility in a Chinese Han population. Methods: In total, 133 T2DM patients and 127 healthy controls matched by age and gender were recruited in the case–control study. IL-16 gene rs4778889 and rs11556218 polymorphisms were genotyped in the two groups via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Differences in genotype and allele distributions between groups were compared by the χ2 test. All the comparisons were adjusted for age, gender, and body mass index (BMI) by logistic regression. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association strength between IL-16 gene polymorphism and T2DM risk. Results: The TG genotype and G allele frequencies of rs11556218 increased remarkably in the case group than that in controls (45.86 vs 33.86%; 29.70 vs 20.87%), and the differences reached a significant level (P<0.05). After adjusting for age, gender, and BMI, the differences still reached a significant level (P<0.05). Rs11556218 TG genotype carriers had a 1.769-fold increased risk of developing T2DM (OR = 1.769, 95% CI = 1.045–2.994), and G allele was also associated with an increased risk of T2DM (OR = 1.639, 95% CI = 1.087–2.471). IL-16 rs4778889 polymorphism showed no significant association with T2DM risk. Conclusion: IL-16 gene rs11556218 polymorphism was significantly associated with T2DM susceptibility in the Chinese Han population, while rs4778889 was not.

scholarly journals Sequence Variants ofADIPOQand Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ming-Kai Tsai ◽  
Hui-Min David Wang ◽  
Jeng-Chuan Shiang ◽  
I-Hung Chen ◽  
Chih-Chiang Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Large Scale ◽  
Association Studies ◽  
Chinese Han Population ◽  
Genome Wide Association Studies ◽  
Chinese Han ◽  
Han Population

Diabetes is a serious global health problem. Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus (T2DM), including adiponectin (ADIPOQ) gene and transcription factor 7-like 2 (TCF7L2), but few studies clarified the effect of genetic polymorphisms ofADIPOQandTCF7L2on risk of T2DM. We attempted to elucidate association between T2DM and polymorphic variations of both in Taiwan’s Chinese Han population, with our retrospective case-control study genotyping single nucleotide polymorphisms (SNPs) inADIPOQandTCF7L2genes both in 149 T2DM patients and in 139 healthy controls from Taiwan. Statistical analysis gauged association of these polymorphisms with risk of T2DM to showADIPOQrs1501299 polymorphism variations strongly correlated with T2DM risk(P=0.042), with rs2241766 polymorphism being not associated with T2DM(P=0.967). However, both polymorphisms rs7903146 and rs12255372 ofTCF7L2were rarely detected in Taiwanese people. This study avers thatADIPOQrs1501299 polymorphism contributes to risk of T2DM in the Taiwanese population.

scholarly journals Association of four insulin resistance genes with type 2 diabetes mellitus and hypertension in the Chinese Han population

2014 ◽  
Vol 41 (2) ◽  
pp. 925-933 ◽  
Author(s):  
Bo Jiang ◽  
Ya Liu ◽  
Yuxin Liu ◽  
Fang Fang ◽  
Xue Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Resistance Genes ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Relationship between type 2 diabetes mellitus and a novel polymorphism C698T in C5L2 in the Chinese Han population

Endocrine ◽  
2011 ◽  
Vol 41 (2) ◽  
pp. 296-301 ◽  
Author(s):  
Ying-Ying Zheng ◽  
Xiang Xie ◽  
Yi-Tong Ma ◽  
Yi-Ning Yang ◽  
Zhen-Yan Fu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Association of TLR4 gene polymorphisms with susceptibility to type 2 diabetes mellitus in the Chinese Han population

2015 ◽  
Vol 24 (1) ◽  
pp. 68-71 ◽  
Author(s):  
Tao Lei ◽  
Wenjun Tang ◽  
Yanqin Xiong ◽  
Yujuan Di ◽  
Keqin Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Tlr4 Gene

scholarly journals TheFOXO1Gene-Obesity Interaction Increases the Risk of Type 2 Diabetes Mellitus in a Chinese Han Population

2017 ◽  
Vol 32 (2) ◽  
pp. 264 ◽  
Author(s):  
Lilin Gong ◽  
Rong Li ◽  
Wei Ren ◽  
Zengchan Wang ◽  
Zhihong Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals The Effect of APOC3 Promoter Polymorphisms on the Risk of Hypertriglyceridemia in Chinese Han Population With or Without Type 2 Diabetes Mellitus

2010 ◽  
Vol 41 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Juan Yu ◽  
Huimin Wang ◽  
Shumei Yang ◽  
Jin Yuan ◽  
Lianying Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chinese Han Population ◽  
Promoter Polymorphisms ◽  
Chinese Han ◽  
Han Population
Sign in / Sign up

Export Citation Format

Share Document