scholarly journals Medical Treatments for Idiopathic Pulmonary Fibrosis: a Protocol for a Systematic Review and Network Meta-analysis

2021 ◽  
Author(s):  
Tyler Pitre ◽  
Jasmine Mah ◽  
Sonya Cui ◽  
Melanie C. Zhang ◽  
Renata Husnudinov ◽  
...  
Keyword(s):  
Systematic Review ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Unknown Etiology ◽  
Controlled Trials ◽  
Respiratory Disorder ◽  
Randomized Controlled ◽  
Medical Therapies

Abstract Background: Idiopathic pulmonary fibrosis (IPF) is a respiratory disorder of unknown etiology with a poor prognosis. There are novel therapies that have been studied in randomized controlled trials since the last network meta-analysis that may be of interest to academics and clinicians.Methods: We will perform a network meta-analysis on eligible randomized controlled trials of patients with IPF. We intend to search MEDLINE, EMBASE, Cochrane and clinicaltrials.org in order to complete a comprehensive search for adult IPF patients being treated with at least one of 21 of the selected medical therapies. A team will screen and extract eligible trials. We will perform Bayesian random-effects network meta-analysis. We will use GRADE and RoB 2.0 to assess the certainty and quality of the evidence. Discussion: There is a need for an updated meta-analysis on IPF medical therapies, including novel medical therapies. We intend on studying up to 21 medical therapies in the network meta-analysis to provide the most accurate and updated summary of the evidence for IPF treatments. Systematic review registrations: https://osf.io/afbhd/

P081 HISTOLOGIC HEALING RATES OF MEDICAL THERAPIES FOR ULCERATIVE COLITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

2019 ◽  
Vol 25 (Supplement_1) ◽  
pp. S38-S38
Author(s):  
Robert Battat ◽  
Marjolijn Duijvestein ◽  
Leonardo Guizzetti ◽  
Daksh Choudhary ◽  
Brigid Boland ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Medical Therapies

P081 HISTOLOGIC HEALING RATES OF MEDICAL THERAPIES FOR ULCERATIVE COLITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

2019 ◽  
Vol 156 (3) ◽  
pp. S54-S55 ◽  
Author(s):  
Robert Battat ◽  
Marjolijn Duijvestein ◽  
Leonardo Guizzetti ◽  
Daksh Choudhary ◽  
Brigid Boland ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Medical Therapies

Mo1824 – Histologic Healing Rates of Medical Therapies for Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2019 ◽  
Vol 156 (6) ◽  
pp. S-851
Author(s):  
Robert Battat ◽  
Marjolijn Duijvestein ◽  
Leonardo Guizzetti ◽  
Daksh Choudhary ◽  
Brigid S. Boland ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Medical Therapies

Interventions to Reduce Alcohol Harms in Low and Middle Income Countries: a Systematic Review and Meta Analysis

2018 ◽  
Author(s):  
Joao Ricardo Nickenig Vissoci
Keyword(s):  
Systematic Review ◽  
Alcohol Use ◽  
Randomized Controlled Trials ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
World Health ◽  
Controlled Trials ◽  
Middle Income ◽  
Brief Motivational Intervention ◽  
Randomized Controlled

BackgroundHarmful alcohol use leads to a large burden of disease and disability which disportionately impacts LMICs. The World Health Organization and the Lancet have issued calls for this burden to be addressed, but issues remain, primarily due to gaps in information. While a variety of interventions have been shown to be effective at reducing alcohol use in HICs, their efficacy in LMICs have yet to be assessed. This systematic review describes the current published literature on alcohol interventions in LMICs and conducts a meta analysis of clinical trials evaluating interventions to reduce alcohol use and harms in LMICs.MethodsIn accordance with PRISMA guidelines we searched the electronic databases Pubmed, EMBASE, Scopus,Web of Science, Cochrane, and Psych Info. Articles were eligible if they evaluated an intervention targeting alcohol-related harm in LMICs. After a reference and citation analysis, we conducted a quality assessment per PRISMA protocol. A meta-analysis was performed on the 39 randomized controlled trials that evaluated an alcohol-related outcome.ResultsOf the 3,801 articles from the literature search, 87 articles from 25 LMICs fit the eligibility and inclusion criteria. Of these studies, 39 randomized controlled trials were included in the meta-analysis. Nine of these studies focused specifically on medication, while the others focused on brief motivational intervention, brain stimulation, AUDIT-based brief interventions, WHO ASSIST-based interventions, group based education, basic screening and interventions, brief psychological or counseling, dyadic relapse prevention, group counseling, CBT, motivational + PTSD based interview, and health promotion/awareness. Conclusion Issues in determining feasible options specific to LMICs arise from unstandardized interventions, unequal geographic distribution of intervention implementation, and uncertain effectiveness over time. Current research shows that brain stimulation, psychotherapy, and brief motivational interviews have the potential to be effective in LMIC settings, but further feasibility testing and efforts to standardize results are necessary to accurately assess their effectiveness.

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