scholarly journals A correlation study of the effectiveness of renal scintigraphy and sonography in the detection and evaluation of renal disorders

2020 ◽  
Author(s):  
Maithaa H. Alsubhi ◽  
Atheer A. Alghanmi ◽  
Yara H. Alzabidi ◽  
Alhanouf K. Bafail ◽  
Saeed Muhammad Bafaraj
Keyword(s):  
Renal Function ◽  
Disease Incidence ◽  
Correlation Study ◽  
Renal Scintigraphy ◽  
Imaging Data ◽  
Renal Ultrasonography ◽  
Renal Anomaly ◽  
Renal Obstruction ◽  
Morphological Findings ◽  
Imaging Tool

Abstract Background: This retrospective study was undertaken to assess correlation between renal scintigraphy employing technetium Tc-99m chelated with radiopharmaceutical drug Diethylenetriamine Penta Acetic Acid (DTPA) and renal ultrasonography morphological findings. Methods: For this purpose, ninety six patients imaging data was statistically analyzed including 43 females and 53 males. All the patients were subjected to renal scintigraphy while 68 patients underwent renal ultrasonography. Renal U/S reported anatomical renal anomaly in 94.1% patients versus 85.4% detected by scintigraphy. There were 41 patients out of 68 diagnosed with hydronephrosis and 21 of them were suffering with mild hydronephrosis as suggested by U/S imaging. Results: Renal scintigraphy of 41 hydronephrotic patients validated that 19 patients having non-obstructive bilateral pelvic dilation while remaining 22 with mild to severe obstruction. Ultrasonography diagnosed 4 patients with renal obstruction. Conversely, renal scintigraphy validated 2 of them with renal obstruction on the basis of renal function. In total, 19 out 96 patients were reported with renal obstruction through scintigraphy and validated obstruction in 1 of the 3 patients who were diagnosed with abnormal postvoid residual volume through U/S. Conclusion: Renal scintigraphy is not significant in diagnosing kidney disease; rather this is a vibrant imaging tool providing supplementary data on the basis of renal function. Effectively targeted intervention regime can be achieved by correlating renal scintigraphy and renal ultrasonography results to minimize renal disease incidence.

1905: The Effect of Percutaneous Nephrolithotripsy (PCNL) on Renal Function: Assessment with Quantitative Spect of TC 99M-DMSA (QDMSA) Renal Scintigraphy

2004 ◽  
Vol 171 (4S) ◽  
pp. 503-503
Author(s):  
Boaz Moskovitz ◽  
Vladimir Sopov ◽  
Sarel Halachmi ◽  
Michael Mullerad ◽  
Yusef Barbara ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Scintigraphy ◽  
Quantitative Spect ◽  
Percutaneous Nephrolithotripsy ◽  
Function Assessment

scholarly journals FRI0177 MULTI-MODALITY IMAGING TO EVALUATE LUPUS NEPHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 672.2-673
Author(s):  
C. Dykas ◽  
B. H. Rovin ◽  
M. Boesen ◽  
O. Kubassova ◽  
P. Lipsky
Keyword(s):  
Image Analysis ◽  
Renal Function ◽  
Rank Correlation ◽  
Renal Perfusion ◽  
Imaging Data ◽  
Spearman Rank Correlation ◽  
Dce Mri ◽  
Analysis Group ◽  
Multi Center Study ◽  
Mean Time

Background:Lupus nephritis (LN) remains a significant cause of morbidity and mortality in subjects with Systemic Lupus Erythematosus (SLE). The gold standard for evaluation of LN remains the kidney biopsy, whereas renal function is usually evaluated by eGFR and urinary protein:creatinine ratio. More effective and sensitive methodology is needed to assess LN and also the response to treatment. Functional imaging of the kidney using quantitative techniques has great potential, as it can assess kidney function and pathologic changes non-invasively by evaluating perfusion, oxygenation, cellular density and fibrosis.Objectives:The objective of this study was to develop a multi-modality imaging approach for the evaluation of the spectrum of pathologic changes in LN and to determine when imaging data correlated with renal functionMethods:In this multi-center study (NCT03180021), subjects who were having a standard of care renal biopsy for LN were asked to participate in the imaging evaluation. Local Institutional Review Board approval was obtained, and subjects signed an Informed Consent Form. Dynamic contrast enhanced MRI (DCE-MRI) was employed to detect changes in vascularization and perfusion, Diffusion Weighted Imaging (DWI) to assess interstitial diffusion, T2*Map/BOLD to evaluate tissue oxygenation and T1rho to evaluate fibrosis (Figure 1). Regions of interest were identified in the imaged kidneys and imaging parameters were correlated with measures of renal function, including eGFR and urinary protein: creatinine ratio. In DCE-MRI, we specifically focused on mean Maximum Enhancement (ME), mean Time to Peak Enhancement (TTP) and mean Time of Washout (Twashout) as indicators of renal perfusion.Results:Nine subjects have been evaluated to date and their imaging data assessed for quality. Evaluation of mean data from DCE-MRI has shown a significant correlation between renal perfusion and renal function. For example, as shown in the figure, the 24 hour protein concentration negatively correlated with ME (rs=-0.81, p=0.015), TTP (rs=-0.83, p=0.01) and Twashout (rs=-0.81.p=0.01, Spearman rank correlation). In addition, the protein:creatinine ratio also negatively correlated with ME (rs=-0.79, p=0.02), TTP (rs=-0.74, p=0.04) and Twashout (rs=-0.79, p=0.02, Spearman rank correlation).Conclusion:These initial results have established the feasibility of multi-modality imaging as a tool to evaluate LN in a multi-center study. Moreover, changes in perfusion detected by DCE-MRI significantly correlate with proteinuria and urinary protein:creatinine ratio. These results suggest that multiparameter imaging may contribute useful data in the evaluation of subjects with LN.Figure:Disclosure of Interests:Claire Dykas: None declared, Brad H Rovin Grant/research support from: GSK, Consultant of: GSK, Mikael Boesen Consultant of: AbbVie, AstraZeneca, Eli Lilly, Esaote, Glenmark, Novartis, Pfizer, UCB, Paid instructor for: IAG, Image Analysis Group, AbbVie, Eli Lilly, AstraZeneca, esaote, Glenmark, Novartis, Pfizer, UCB (scientific advisor)., Speakers bureau: Eli Lilly, Esaote, Novartis, Pfizer, UCB, Olga Kubassova Shareholder of: IAG, Image Analysis Group, Consultant of: Novartis, Takeda, Lilly, Employee of: IAG, Image Analysis Group, Peter Lipsky Consultant of: Horizon Therapeutics

scholarly journals Renal scintigraphy in infants with antenatally diagnosed renal pelvis dilatation

2008 ◽  
Vol 65 (4) ◽  
pp. 299-302
Author(s):  
Boris Ajdinovic ◽  
Ljiljana Jaukovic ◽  
Amira Peco-Antic ◽  
Sanja Dugonjic
Keyword(s):  
Renal Function ◽  
Vesicoureteral Reflux ◽  
Ureteropelvic Junction Obstruction ◽  
No Reduction ◽  
Renal Scintigraphy ◽  
Newborn Period ◽  
Antenatal Hydronephrosis ◽  
Differential Renal Function ◽  
Renal Pelvis Dilatation

Background/Aim. Ureteropelvic junction obstruction and vesicoureteral reflux are the most frequent entities identified on the basis of antenatal hydronephrosis. The aim of this study was to determine the incidence and pattern of abnormal renal scintigraphy findings in postnatal investigation of children with antenatal hydronephrosis. Methods. Twenty four infants (19 boys and five girls) presented with antenatal hydronephrosis and mild to moderate hydronephrosis on ultrasound in newborn period were referred for renal scintigraphy. Ten patients with vesicoureteral reflux documented on micturating cystoureterography underwent 99mTc-DMSA renal scintigraphy and 14 patients were subjected to 99mTc-DTPA scintigraphy. Results. Anteroposterior pelvic diameter on ultrasound ranged from 11 to 24 mm. Renal DMSA scans identified congenital scars in two boys with bilateral reflux of grade V and unilateral reflux of grade III. Relative kidney uptake (RKU) less than 40% was found in three, and poor kidney function (RKU less than 10%) in two patients. Significant obstruction was shown on DTPA diuretic renal scintigraphy in 6/14 patients. Some slowing in dranaige (T1/2 greater than 10 minutes) with no reduction in differential renal function was identified in three patients. Differential renal function less than 10% was obtained in one case. Conclusion. A high percent of abnormal renal scintigraphy findings was obtained. Renal scintigraphy was useful in determination of underlying cause of antenatally detected hydronephrosis.

scholarly journals NIfTI-MRS: A standard format for magnetic resonance spectroscopic data

2021 ◽  
Author(s):  
William T Clarke ◽  
Mark Mikkelsen ◽  
Georg Oeltzschner ◽  
Tiffany Bell ◽  
Amirmohammad Shamaei ◽  
...  
Keyword(s):  
Data Sharing ◽  
Open Data ◽  
Imaging Data ◽  
Standard Format ◽  
Conversion Point ◽  
Imaging Tool ◽  
Data Formats ◽  
Multiple Data ◽  
Single Voxel ◽  
Online Documentation

Purpose: The use of multiple data formats in the MRS community currently hinders data sharing and integration. NIfTI-MRS is proposed as a standard MR spectroscopy data format, which is implemented as an extension to the neuroimaging informatics technology initiative (NIfTI) format. Using this standardised format will facilitate data sharing, ease algorithm development, and encourage the integration of MRS analysis with other imaging modalities. Methods: A file format based on the NIfTI header extension framework was designed to incorporate essential spectroscopic metadata and additional encoding dimensions. A detailed description of the specification is provided. An open-source command-line conversion program is implemented to enable conversion of single-voxel and spectroscopic imaging data to NIfTI-MRS. To provide visualisation of data in NIfTI-MRS, a dedicated plugin is implemented for FSLeyes, the FSL image viewer. Results: Alongside online documentation, ten example datasets are provided in the proposed format. In addition, minimal examples of NIfTI-MRS readers have been implemented. The conversion software, spec2nii, currently converts fourteen formats to NIfTI-MRS, including DICOM and vendor proprietary formats. Conclusion: The proposed format aims to solve the issue of multiple data formats being used in the MRS community. By providing a single conversion point, it aims to simplify the processing and analysis of MRS data, thereby lowering the barrier to use of MRS. Furthermore, it can serve as the basis for open data sharing, collaboration, and interoperability of analysis programs. It also opens possibility of greater standardisation and harmonisation. By aligning with the dominant format in neuroimaging, NIfTI-MRS enables the use of mature tools present in the imaging community, demonstrated in this work by using a dedicated imaging tool, FSLeyes, as a viewer.

Evaluation of renal function after laparoscopic partial nephrectomy with renal scintigraphy using 99mtechnetium-mercaptoacetyltriglycine

2006 ◽  
Vol 13 (11) ◽  
pp. 1371-1374 ◽  
Author(s):  
KOBAYASHI YASUYUKI ◽  
USUI YUKIO ◽  
SHIMA MASANORI ◽  
AKIO HOSHI ◽  
MIYAKITA HIDESHI ◽  
...  
Keyword(s):  
Renal Function ◽  
Partial Nephrectomy ◽  
Laparoscopic Partial Nephrectomy ◽  
Renal Scintigraphy

scholarly journals Detecting Wheat Powdery Mildew and Predicting Grain Yield Using Unmanned Aerial Photography

Plant Disease ◽  
2018 ◽  
Vol 102 (10) ◽  
pp. 1981-1988 ◽  
Author(s):  
Wei Liu ◽  
Xueren Cao ◽  
Jieru Fan ◽  
Zhenhua Wang ◽  
Zhengyuan Yan ◽  
...  
Keyword(s):  
Powdery Mildew ◽  
Grain Yield ◽  
Disease Severity ◽  
Flight Altitude ◽  
Imaging Data ◽  
Remote Imaging ◽  
Wheat Powdery Mildew ◽  
Imaging Tool ◽  
Random Coefficient Regression ◽  
Relationship Of

High-resolution aerial imaging with an unmanned aerial vehicle (UAV) was used to quantify wheat powdery mildew and estimate grain yield. Aerial digital images were acquired at Feekes growth stage (GS) 10.5.4 from flight altitudes of 200, 300, and 400 m during the 2009–10 and 2010–11 seasons; and 50, 100, 200, and 300 m during the 2011–12, 2012–13, and 2013–14 seasons. The image parameter lgR was consistently correlated positively with wheat powdery mildew severity and negatively with wheat grain yield for all combinations of flight altitude and year. Fitting the data with random coefficient regression models showed that the exact relationship of lgR with disease severity and grain yield varied considerably from year to year and to a lesser extent with flight altitude within the same year. The present results raise an important question about the consistency of using remote imaging information to estimate disease severity and grain yield. Further research is needed to understand the nature of interyear variability in the relationship of remote imaging data with disease or grain yield. Only then can we determine how the remote imaging tool can be used in commercial agriculture.

scholarly journals A Rare Case of Isolated Ureteral Diaphragmatic Herniation: Case Report and Review of Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Nassib Abou Heidar ◽  
Hussein Elsemesmani ◽  
Ahmad Elamine ◽  
Mustafa Natout
Keyword(s):  
Renal Function ◽  
Case Report ◽  
Rare Case ◽  
Management Strategies ◽  
Treatment Strategies ◽  
Review Of Literature ◽  
Serial Imaging ◽  
Renal Obstruction ◽  
Ureteral Stenting ◽  
Diaphragmatic Herniation

Diaphragmatic ureteral hernias are rare causes of ipsilateral renal obstruction. Management strategies varies from conservative to ureteral stenting to operative herniorraphy and reduction. We present a case of a 71-year-old man who was found to have an incidental right ureteral diaphragmatic herniation causing an asymptomatic kidney obstruction. He was managed conservatively with no evidence of increased hydronephrosis on serial imaging and no deterioration of biochemical renal function. We review all similar cases published in the literature and discuss the optimal treatment strategies.

Separate Renal Function Evaluation by I 131-Hippuran in Chronic Renal Obstruction

1981 ◽  
pp. 221-224
Author(s):  
M. Mebel ◽  
P. Müller ◽  
B. Schönberger ◽  
D. Strangfeld ◽  
H. Siewert
Keyword(s):  
Renal Function ◽  
Function Evaluation ◽  
Renal Obstruction

scholarly journals Renal Function Assessment Gap in Clinical Practice: An Awkward Truth

2020 ◽  
Vol 45 (2) ◽  
pp. 166-179 ◽  
Author(s):  
Francesco Trevisani ◽  
Federico Di Marco ◽  
Umberto Capitanio ◽  
Alessandro Larcher ◽  
Arianna Bettiga ◽  
...  
Keyword(s):  
Renal Function ◽  
Clinical Practice ◽  
Plasma Clearance ◽  
Renal Scintigraphy ◽  
Study Cohort ◽  
Clinical Settings ◽  
Gold Standard Method ◽  
Disease Epidemiology ◽  
Iohexol Plasma Clearance ◽  
Gold Standards

Introduction: An accurate assessment of renal function is needed in the majority of clinical settings. Unfortunately, the most used estimated glomerular filtration rate (eGFR) formulas are affected by significant errors in comparison to gold standards methods of measured GFR (mGFR). Objective: The objective of the study is to determine the extent of the error of eGFR formulas compared to the mGFR in different specific clinical settings. Methods: A total retrospectively consecutive cohort of 1,320 patients (pts) enrolled in 2 different European Hospitals (Center 1: 470 pts; Center 2: 850 pts) was collected in order to compare the most common eGFR formulas used by physicians with the most widespread mGFR methods in daily clinical practice (Iohexol Plasma Clearance -Center 1 [mGFR-iox] and Renal Scintigraphy -Center 2 [mGFR-scnt]). The study cohort was composed by urological, oncological, and nephrological pts. The agreement between eGFR and mGFR was evaluated using bias (as median of difference), precision (as interquartile range of difference) accuracy (as P30), and total deviation index. Results: The most accurate eGFR formula in the comparison with gold standard method (Iohexol plasma clearance) in Center 1 was represented by s-creatinine and cystatin C combined Chronic Kidney Disease-Epidemiology Collaboration-cr-cy, even though the P30 is reduced (84%) under the threshold of 60 mL/min/1.73 m2. Similar results were found in Center 2, with a wider discrepancy between mGFR-scnt and eGFR formulas due to the minor accuracy of the nuclear tool in respect to the mGFR-iox. Conclusions: The loss of accuracy observed for the formulas at lower values of GFR suggests the mandatory use of gold standards methods as Iohexol Plasma Clearance to assess the correct status of renal function for critical cases. The center 2 showed lower levels of agreement between mGFR and eGFR suggesting that the errors are partially accounted for the Renal Scintigraphy technique too. In particular, we suggest the use of mGFR-iox in oncological urological and nephrological pts with an eGFR lower than 60 mL/min/1.73 m2.

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