scholarly journals ZFX expression is connected with improved survival in patients with breast cancer

2021 ◽  
Author(s):  
Gideon Carney ◽  
Duncan Bush ◽  
Scarlet Sellers ◽  
Roan Carpenter ◽  
Maira Hewitt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Survival Data ◽  
Cancer Survival ◽  
Zinc Finger Protein ◽  
Metastatic Breast ◽  
Stage Iv ◽  
Metastatic Tumor ◽  
Finger Protein ◽  
Tumor Tissues ◽  
Protein X

Abstract We analyzed published tumor transcriptome data in conjunction with linked survival data to identify genes linked with breast cancer survival outcomes (1, 2). When comparing tumor transcriptomes based on 24-month survival, we discovered that the zinc-finger protein X-linked ZFX (3, 4) was among the most differentially expressed genes in both original and metastatic tumor tissues. ZFX expression was considerably enhanced in metastatic tumors of patients who survived more than 24 months, indicating that enhanced ZFX expression offers a survival advantage for patients with stage IV metastatic breast cancer.

scholarly journals Expression of zinc-finger protein X-linked, ZFX, is associated with enhanced survival in patients with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Zinc Finger ◽  
Survival Data ◽  
Zinc Finger Protein ◽  
Metastatic Breast ◽  
Stage Iv ◽  
Metastatic Tumor ◽  
Finger Protein ◽  
Tumor Tissues ◽  
Protein X

We mined published tumor transcriptome data with paired survival data to discover genes associated with survival outcomes in breast cancer (1, 2). We found that the zinc-finger protein X-linked ZFX (3, 4) was among the genes most differentially expressed in both primary and metastatic tumor tissues when comparing tumor transcriptomes based on survival at 24 months. ZFX expression was significantly higher in the metastatic tumors of patients surviving greater than 24 months, suggesting that increased ZFX expression confers a survival benefit to patients with stage IV metastatic breast cancer.

scholarly journals ZNF248 is a differentially expressed gene in brain metastatic human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Zinc Finger Protein ◽  
Differentially Expressed Gene ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Primary Tumors ◽  
Finger Protein ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that zinc finger protein 248, encoded by ZNF248, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ZNF248 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of ZNF248 in primary tumors was significantly correlated with patient overall survival. Modulation of ZNF248 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

scholarly journals The neighbor to BRCA1 gene 1, NBR1, is differentially expressed in human breast cancers and its expression positively associates with survival.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Cancer Survival ◽  
Disease Free Survival ◽  
Metastatic Breast ◽  
Stage Iv ◽  
Brca1 Gene ◽  
Metastatic Tumor ◽  
The United States ◽  
Differentially Expressed ◽  
Breast Cancers

Breast cancer is a leading cause of cancer death for women in the United States (1) and metastasis, or spread of the disease beyond the breast is the central reason women with breast cancer die (2). We utilized a systems-level approach to discover genes associated with breast cancer survival by comparing primary and metastatic tumor transcriptomes based on survival greater or less than 24 months using published datasets (3, 4). We found that the autophagy cargo receptor Neighbor to BRCA1 gene, NBR1 was among the genes most significantly differentially expressed between the tumors of women with disease-free survival more or less than 24 months (3). Analysis of a separate dataset (4), here comparing metastatic tissues of women with breast cancer based on overall survival, again identified NBR1 among the genes whose expression was most significantly different, genome-wide, between women surviving more than 24 months as compared to women who expired before 24 months. NBR1 was recently reported as a regulator of metastasis in mouse models of breast cancer (5). Our findings reveal that NBR1 is expressed at significantly higher levels in women who survive stage IV metastatic breast cancer greater than 24 months as compared to those who will expire from the disease before 24 months, and are in distinct opposition with recently published mechanistic studies in mice suggesting that NBR1 inhibition is anti-metastatic (5). The fact that NBR1 is among the genes whose expression is most significantly higher in the primary and metastatic tumors of patients based on survival outcomes greater than 24 months and expressed significantly higher among survivors, suggests that NBR1 inhibition will not be effective in halting metastasis and should be approached with caution.

scholarly journals ZNF226 is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Zinc Finger Protein ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Primary Tumors ◽  
Finger Protein ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the zinc finger protein 226, encoded by ZNF226 was among the genes whose expression was most different in the brain metastases of patients with brain metastatic breast cancer as compared to primary tumors of the breast. ZNF226 may be relevant to processes underlying metastasis of primary tumor-derived cancer cells to the brain in humans with metastatic breast cancer.

scholarly journals Versican (VCAN) is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Primary Tumors ◽  
Tumor Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the chondroitin sulfate proteoglycan versican, encoded by VCAN, was among the genes whose expression was most different in the metastatic tumor tissues of patients with metastatic breast cancer, both in metastases to brain and to the lymph nodes when compared to primary tumors of the breast. Molecular functions (6-9) and down-regulation of VCAN may be important for metastasis of primary tumor-derived cancer cells to the lymph nodes and to the brain in humans with metastatic breast cancer, and suggests some level of common origin for metastases that reside in the lymph nodes and colonize the brain.

scholarly journals SERPINF1 is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Down Regulation ◽  
Primary Tumors ◽  
Tumor Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the serpin family F member 1, encoded by SERPINF1, was among the genes whose expression was most different in the metastatic tumor tissues of patients with metastatic breast cancer, both in metastases to brain and to the lymph nodes when compared to primary tumors of the breast. We observed significant down-regulation of SERPINF1 in metastasis to the brain. Molecular functions and down-regulation of SERPINF1 may be important for metastasis of primary tumor-derived cancer cells to the lymph nodes and to the brain in humans with metastatic breast cancer, and suggests some level of common origin for metastases that reside in the lymph nodes and colonize the brain.

scholarly journals Microfibrillar-associated protein 5 (MFAP5) is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Primary Tumors ◽  
Tumor Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the microfibrillar-associated protein 5, encoded by MFAP5, was among the genes whose expression was most different in the metastatic tumor tissues of patients with metastatic breast cancer, both in metastases to brain and to the lymph nodes when compared to primary tumors of the breast. Molecular functions and down-regulation of MFAP5 may be important for metastasis of primary tumor-derived cancer cells to the lymph nodes and to the brain in humans with metastatic breast cancer, and suggests some level of common origin for metastases that reside in the lymph nodes and colonize the brain.

scholarly journals Decorin is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Primary Tumors ◽  
Tumor Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that decorin, encoded by DCN, was among the genes whose expression was most different in the metastatic tumor tissues of patients with metastatic breast cancer, both in metastases to brain and to the lymph nodes when compared to primary tumors of the breast. Molecular functions and down-regulation of DCN may be important for metastasis of primary tumor-derived cancer cells to the lymph nodes and to the brain in humans with metastatic breast cancer, and suggests some level of common origin for metastases that reside in the lymph nodes and colonize the brain.

scholarly journals Laminin 4 is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Primary Tumors ◽  
Tumor Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that laminin 4, encoded by LAMA4, was among the genes whose expression was most different in the metastatic tumor tissues of patients with metastatic breast cancer, both in metastases to brain and to the lymph nodes when compared to primary tumors of the breast. Molecular functions and down-regulation of LAMA4 may be important for metastasis of primary tumor-derived cancer cells to the lymph nodes and to the brain in humans with metastatic breast cancer, and suggests some level of common origin for metastases that reside in the lymph nodes and colonize the brain.

scholarly journals Twist2 is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Normal Breast ◽  
Primary Tumors ◽  
Tumor Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that Twist2 was among the genes whose expression was most different in the metastatic tumor tissues of patients with metastatic breast cancer, both in metastases to brain and to the lymph nodes when compared to primary tumors of the breast or to normal breast tissues, respectively. Molecular functions of Twist2 and down-regulation of these functions may be important for metastasis of primary tumor-derived cancer cells to the lymph nodes and to the brain in humans with metastatic breast cancer, and these data suggest some level of common origin for metastases that reside in the lymph nodes and colonize the brain.

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