Health-related Quality of Life and Insulin Resistance: a Longitudinal Study
Abstract The aim of the study was to investigate insulin resistance (IR) in association with health-related quality of life (HRQoL) among citizens of Palanga in a ten years follow-up. A randomized epidemiological study was performed out for 835 subjects. All study participants were evaluated according to for socio-demographic characteristics, behavioral factors, HRQoL and self-perceived health using questionnaires. Fasting blood samples were draw from all participants and biochemical tests were performed for the glucose, insulin. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). In subjects with IR, after adjusting with various factors, logistic regression analysis showed, that within 10 years, a significantly higher chance of deteriorating HRQoL in the areas of: physical functioning (odss ratio [OR] = 1.15, p < 0.001), emotional role limitations (OR = 1.07, p = 0.034), social functioning (OR = 1.26, p = 0.004), pain (OR = 1.09, p = 0.005) and general health perception (OR = 1.07, p = 0.022). People with IR have a worse HRQoL and as they age, they are significantly more likely to have a deterioration in their HRQoL compared to people without IR in the areas of physical functioning, emotional role limitations, social functioning, pain and general health perception.