Recent Injury and Health-Related Quality of Life in Adolescent Athletes

Abstract Context: Health-related quality of life (HRQOL) is a global concept that takes into account the physical, psychological, and social domains of health. Determining the extent to which injury affects HRQOL is an important aspect of rehabilitation practice, enabling comparisons of clinical outcomes across different conditions in diverse patient groups. Objective: To examine the extent to which a self-reported recent injury affected HRQOL in adolescent athletes using 2 generic patient self-report scales. Design: Cross-sectional study. Setting: High school classrooms and athletic training facilities. Patients or Other Participants: A convenience sample of uninjured (n = 160) and injured (n = 45) adolescent athletes. Intervention(s): The independent variable was injury status: uninjured versus injured. All participants completed a self-administered brief health status questionnaire and the Short Form–36 Health Survey Questionnaire (SF-36) and Pediatric Outcomes Data Collection Instrument (PODCI) in a counterbalanced manner. Main Outcome Measure(s): Dependent variables included 8 subscale and 2 composite scores of the SF-36 and 5 subscale scores and 1 global score of the PODCI. Group differences were assessed with the Mann-Whitney U test (P ≤ .05) and reported as median and interquartile range. Results: On the SF-36, the injured group demonstrated lower scores (P < .008) for physical functioning, limitations due to physical health problems, bodily pain, social functioning, and the physical composite. On the PODCI, the injured group reported lower scores (P < .01) on the pain and comfort subscale and the global score. Conclusions: Adolescent athletes with self-reported injuries demonstrated lower HRQOL than their uninjured peers. As expected, recent injury affected physical functioning and pain. Social functioning (on the SF-36) and global HRQOL (on the PODCI) also decreased, suggesting that injuries affected areas beyond the expected physical component of health. Clinicians need to recognize the full spectrum of negative influences that injuries may have on HRQOL in adolescent athletes.

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Impact of duration and treatment of arterial hypertension on health-related quality of life

Medicina ◽

10.3390/medicina45050051 ◽

2009 ◽

Vol 45 (5) ◽

pp. 405 ◽

Cited By ~ 3

Author(s):

Vilma Raškelienė ◽

Marija Babarskienė ◽

Jūratė Macijauskienė ◽

Arvydas Šeškevičius

Keyword(s):

Quality Of Life ◽

Arterial Hypertension ◽

Physical Health ◽

Physical Functioning ◽

Health Related Quality ◽

General Evaluation ◽

Sf 36 ◽

Related Quality ◽

Health Related

Arterial hypertension (AH) is one of the most important risk factors for development of ischemic heart disease; thus, control of AH and effective treatment are of great importance. Since arterial hypertension is commonly referred as asymptomatic condition, the question whether hypertensive condition is associated with the change of well-being and health-related quality of life is still debatable. The aim of the study. To evaluate the impact of duration and treatment of AH on health-related quality of life. Material and methods. The contingent of the study consisted of patients who arrived for a cardiologist’s consultation at the Clinic of Cardiology, Hospital of Kaunas University of Medicine. The patients were randomly selected for the study. The inclusion criteria were as follows: diagnosed arterial hypertension, diabetes mellitus, and the metabolic syndrome. Diagnosed ischemic heart disease (chronic and acute coronary syndromes and their complications) and severe concomitant diseases were exclusion criteria. A total of 101 patients (19 males and 82 females) met the inclusion criteria and consented to participate in the study. Their mean age was 58.03±5.63 years. The patients’ quality of life was evaluated using the Medical Outcomes Study short form 36-item questionnaire (SF-36 questionnaire), which comprises 36 questions grouped into eight domains. The questionnaire was filled in by the subjects independently. Other methods applied to the study were inquiry (for the evaluation of risk factors, lifestyle, and medical history), analysis of medical documents (cholesterol levels and glycemia in blood), and objective examination (height, weight, waist circumference, and arterial blood pressure). Results. The subjects with AH showed lower values compared to normotensive patients in the following domains: physical functioning (P=0.014), role limitations due to physical health (P=0.012), energy/vitality (P=0.016), and general health evaluation (P=0.023). We have not determined the differences in quality of life of the patients whose AH was regulated if compared to those patients without AH. The patients whose treatment of AH was not effective reported lower quality of life in the following SF-36 domains: physical functioning (P=0.003), role limitations due to physical health (P=0.003), general evaluation of health (P=0.017), energy/vitality (P=0.008), and emotional status (P=0.015), if compared to the patients without AH. Conclusions. Patients with AH reported lower quality of life in the following domains: physical functioning, role limitations due to physical health, energy/vitality, and general evaluation of health. Compared to patients without AH, the quality of life of the patients who had the effective treatment did not differ, whereas patients with ineffective treatment had the lower quality of life. Functioning is more statistically significantly limited due to physical health in patients with AH.

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A Unique Patient Population? Health-Related Quality of Life in Adolescent Athletes Versus General, Healthy Adolescent Individuals

Journal of Athletic Training ◽

10.4085/1062-6050-48.2.12 ◽

2013 ◽

Vol 48 (2) ◽

pp. 233-241 ◽

Cited By ~ 21

Author(s):

Kenneth C. Lam ◽

Alison R. Snyder Valier ◽

R. Curtis Bay ◽

Tamara C. Valovich McLeod

Keyword(s):

Quality Of Life ◽

Social Functioning ◽

Normative Values ◽

Health Related Quality ◽

Adolescent Athletes ◽

Healthy Adolescent ◽

Related Quality ◽

Health Related ◽

Functioning Subscale

Context: Normative scores for patient-rated outcome (PRO) instruments are important for providing patient-centered, whole-person care and making informed clinical decisions. Although normative values for the Pediatric Quality of Life Generic Core Scale (PedsQL) have been established in the general, healthy adolescent population, whether adolescent athletes demonstrate similar values is unclear. Objective: To compare PedsQL scores between adolescent athletes and general, healthy adolescent individuals. Design: Cross-sectional study. Setting: Secondary schools. Patients or Other Participants: A convenience sample of 2659 interscholastic athletes (males = 2059, females = 600, age = 15.7 ± 1.1 years) represented the athlete group (ATH), and a previously published normative dataset represented the general, healthy adolescent group (GEN). Intervention(s): All participants completed the PedsQL during 1 testing session. Main Outcome Measure(s): The PedsQL consists of 2 summary scores (total, psychosocial) and 4 subscale scores (physical, emotional, social, school), with higher scores indicating better health-related quality of life (HRQOL). Groups were stratified by age (14, 15, or 16 years old). Independent-samples t tests were conducted to compare between-groups and sex differences. Results: The ATH group scored higher than the GEN group across all ages for total and psychosocial summary scores and for emotional and social functioning subscale scores (P ≤ .005). For physical functioning, scores of the 15-year-old ATH were higher than for their GEN counterparts (P = .001). Both 14- and 15-year-old ATH scored higher than their GEN counterparts for the school functioning subscale (P ≤ .013), but differences between 16-year olds were not significant (P = .228). Male adolescent athletes reported higher scores than female adolescent athletes across all scores (P ≤ .001) except for social functioning (P = .229). Conclusions: Adolescent athletes reported better HRQOL than GEN, particularly in emotional functioning. These findings further support the notion that ATH constitutes a unique population that requires its own set of normative values for self-reported, patient-rated outcome instruments.

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Health related quality of life in COVID-19 survivors discharged from acute hospitals: results of a short-form 36-item survey

F1000Research ◽

10.12688/f1000research.50781.1 ◽

2021 ◽

Vol 10 ◽

pp. 282

Author(s):

Alessia Saverino ◽

Eva Zsirai ◽

Raphael Sonabend ◽

Lorenza Gaggero ◽

Isabella Cevasco ◽

...

Keyword(s):

Quality Of Life ◽

Physical Functioning ◽

Short Form ◽

Health Related Quality ◽

Short Form 36 ◽

Sf 36 ◽

Related Quality ◽

Health Related ◽

The Impact

Background: Health-related quality of life (HRQL) is important for evaluating the impact of a disease in the longer term across the physical and psychological domains of human functioning. The aim of this study is to evaluate HRQL in COVID-19 survivors in Italy using the short form 36-items questionnaire (SF-36). Methods: This is an observational study involving adults discharged home following a coronavirus disease 2019 (COVID-19)-related hospital admission. Baseline demographic and clinical data including the Cumulative Illness Rating Scale (CIRS) and the Hospital Anxiety and Depression Scale (HADS) were collected. The validated Italian version of SF-36 was administered cross-sectionally. The SF-36 contains eight scales measuring limitations in physical and social functioning, the impact on roles and activities, fatigue, emotional well-being, pain and general health perception. Results: A total of 35 patients, with a mean age of 60 years, completed the SF-36. The results showed difficulties across the physical and psychological domains, particularly affecting the return to previous roles and activities. A higher burden of co-morbidities as well as a more severe muscle weakness was associated to a lower physical functioning. Younger age, rather than older, correlated to a perceived greater limitation in physical functioning and vitality. Conclusions: COVID-19 survivors particularly the ones of working age may need support for resuming their premorbid level of functioning and returning to work.

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Health-related Quality of Life and Insulin Resistance: a Longitudinal Study

10.21203/rs.3.rs-651299/v1 ◽

2021 ◽

Author(s):

Kazukauskiene Nijole ◽

Podlipskyte Aurelija ◽

Varoneckas Giedrius ◽

Mickuviene Narseta

Keyword(s):

Quality Of Life ◽

Insulin Resistance ◽

Social Functioning ◽

Physical Functioning ◽

General Health ◽

Health Related Quality ◽

Emotional Role ◽

Related Quality ◽

Health Related

Abstract The aim of the study was to investigate insulin resistance (IR) in association with health-related quality of life (HRQoL) among citizens of Palanga in a ten years follow-up. A randomized epidemiological study was performed out for 835 subjects. All study participants were evaluated according to for socio-demographic characteristics, behavioral factors, HRQoL and self-perceived health using questionnaires. Fasting blood samples were draw from all participants and biochemical tests were performed for the glucose, insulin. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). In subjects with IR, after adjusting with various factors, logistic regression analysis showed, that within 10 years, a significantly higher chance of deteriorating HRQoL in the areas of: physical functioning (odss ratio [OR] = 1.15, p < 0.001), emotional role limitations (OR = 1.07, p = 0.034), social functioning (OR = 1.26, p = 0.004), pain (OR = 1.09, p = 0.005) and general health perception (OR = 1.07, p = 0.022). People with IR have a worse HRQoL and as they age, they are significantly more likely to have a deterioration in their HRQoL compared to people without IR in the areas of physical functioning, emotional role limitations, social functioning, pain and general health perception.

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Impact of overweight and obesity on patient-reported health-related quality of life in systemic lupus erythematosus

Rheumatology ◽

10.1093/rheumatology/keaa453 ◽

2020 ◽

Author(s):

Alvaro Gomez ◽

Fawz Hani Butrus ◽

Petter Johansson ◽

Emil Åkerström ◽

Sofia Soukka ◽

...

Keyword(s):

Quality Of Life ◽

Linear Regression ◽

Social Functioning ◽

Overweight And Obesity ◽

Health Related Quality ◽

Sf 36 ◽

Related Quality ◽

Health Related ◽

The Impact

Abstract Objectives Associations between BMI and health-related quality of life (HRQoL) in SLE have been implied, but data are scarce. We determined the impact of overweight and obesity on HRQoL in a large SLE population. Methods We pooled cross-sectional baseline data from the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials (N = 1684). HRQoL was evaluated using the 36-item Short Form Health Survey (SF-36), Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale and the European Quality of Life 5-dimension questionnaire (EQ-5D). Comparisons between BMI groups were conducted using the Mann–Whitney U test and adjustments using linear regression. Clinical relevance was determined by minimal clinically important differences (MCIDs). Results In total, 43.2% of the patients had BMI above normal and 17.4% were obese. Overweight and obese patients reported worse SF-36 physical component summary (PCS), physical functioning, role physical, bodily pain and FACIT-Fatigue scores than normal weight patients. Divergences were greater than corresponding MCIDs and more prominent with increasing BMI. Despite no clinically important difference in SF-36 mental component summary scores across BMI categories, patients experienced progressively diminished vitality and social functioning with increasing BMI. In linear regression analysis, BMI above normal and obesity were associated with worse PCS (standardized coefficient β = −0.10, P < 0.001 and β = −0.17, P < 0.001, respectively), FACIT-Fatigue (β = −0.11, P < 0.001 and β = −0.16, P < 0.001) and EQ-5D (β = −0.08, P = 0.001 and β = −0.12, P < 0.001) scores, independently of demographic and disease-related factors. The impact of BMI on the PCS and FACIT-Fatigue was more pronounced than that of SLE activity. Conclusion Patients with SLE and BMI above normal experienced clinically important HRQoL diminutions in physical aspects, fatigue and social functioning. A survey of potential causality underlying this association is warranted.

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High levels of interleukin-6 in patients with rheumatoid arthritis are associated with greater improvements in health-related quality of life for sarilumab compared with adalimumab

Arthritis Research & Therapy ◽

10.1186/s13075-020-02344-3 ◽

2020 ◽

Vol 22 (1) ◽

Author(s):

Vibeke Strand ◽

Susan H. Boklage ◽

Toshio Kimura ◽

Florence Joly ◽

Anita Boyapati ◽

...

Keyword(s):

Quality Of Life ◽

Rheumatoid Arthritis ◽

Physical Functioning ◽

Interleukin 6 ◽

Phase Iii ◽

Health Related Quality ◽

Sf 36 ◽

Related Quality ◽

Health Related

Abstract Background Increased levels of cytokines, including interleukin-6 (IL-6), reflect inflammation and have been shown to be predictive of therapeutic responses, fatigue, pain, and depression in patients with rheumatoid arthritis (RA), but limited data exist on associations between IL-6 levels and health-related quality of life (HRQoL). This post hoc analysis of MONARCH phase III randomized controlled trial data evaluated the potential of baseline IL-6 levels to differentially predict HRQoL improvements with sarilumab, a fully human monoclonal antibody directed against both soluble and membrane-bound IL-6 receptor α (anti-IL-6Rα) versus adalimumab, a tumor necrosis factor α inhibitor, both approved for treatment of active RA. Methods Baseline serum IL-6 levels in 300/369 randomized patients were categorized into low (1.6–7.1 pg/mL), medium (7.2–39.5 pg/mL), and high (39.6–692.3 pg/mL) tertiles. HRQoL was measured at baseline and week (W)24 and W52 by Short Form 36 (SF-36) physical/mental component summary (PCS/MCS) and domain scores, Functional Assessment of Chronic Illness Therapy -fatigue, and duration of morning stiffness visual analog scale (AM-stiffness VAS). Linear regression of changes from baseline in HRQoL (IL-6 tertile, treatment, region as a stratification factor, and IL-6 tertile-by-treatment interaction as fixed effects) assessed predictivity of baseline IL-6 levels, with low tertile as reference. Pairwise comparisons of improvements between treatment groups were performed by tertile; least squares mean differences and 95% CIs were calculated. Similar analyses evaluated W24 patient-level response on minimum clinically important differences (MCID). Results At baseline, patients with high versus medium or low IL-6 levels (n = 100, respectively) reported worse (nominal p < 0.05) SF-36 MCS and role-physical, bodily pain, social functioning, role-emotional domain, and AM-stiffness VAS scores. There was a greater treatment effect with sarilumab versus adalimumab in high tertile versus low tertile groups in SF-36 PCS, physical functioning domain, and AM-stiffness VAS (nominal interaction p < 0.05). PCS improvements ≥MCID were higher in high (odds ratio [OR] 6.31 [2.37, 16.81]) versus low (OR 0.97 [0.43, 2.16]) tertiles with sarilumab versus adalimumab (nominal interaction p < 0.05). Adverse events between IL-6 tertiles were similar. Conclusions Patients with high baseline IL-6 levels reported better improvements in PCS, physical functioning domain, and AM-stiffness scores with sarilumab versus adalimumab and safety consistent with IL-6R blockade. Trial registration NCT02332590. Registered on 5 January 2015

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Health-Related Quality of Life and Frailty in Chronic Liver Diseases

Life ◽

10.3390/life10050076 ◽

2020 ◽

Vol 10 (5) ◽

pp. 76 ◽

Cited By ~ 2

Author(s):

Hiroki Nishikawa ◽

Kazunori Yoh ◽

Hirayuki Enomoto ◽

Yoshinori Iwata ◽

Yoshiyuki Sakai ◽

...

Keyword(s):

Quality Of Life ◽

Physical Functioning ◽

Summary Score ◽

Chronic Liver ◽

Health Related Quality ◽

Sf 36 ◽

Related Quality ◽

Health Related ◽

Frailty Score

We sought to examine the relationship between frailty and health-related quality of life as evaluated using the 36-item Short-Form Health Survey (SF-36) questionnaire in Japanese chronic liver disease (CLD) patients (n = 341, 122 liver cirrhosis cases, median age = 66 years). Frailty was defined as a clinical syndrome in which three or more of the following criteria were met (frailty score 3, 4, or 5): unintentional body weight loss, self-reported exhaustion, muscle weakness (grip strength: <26 kg in men and <18 kg in women), slow walking speed (<1.0 m/s), and low physical activity. Robust (frailty score 0), prefrail (frailty score 1 or 2), and frailty were found in 108 (31.7%), 187 (54.8%), and 46 (13.5%) patients, respectively. In all eight scales of the SF-36 (physical functioning, role physical, bodily pain, general health perception, vitality, social functioning, role emotion, and mental health), and the physical component summary score and mental component summary score, each score was well stratified according to the frailty status (all p < 0.0001). In the multivariate analysis, age (p = 0.0126), physical functioning (p = 0.0005), and vitality (p = 0.0246) were independent predictors linked to the presence of frailty. In conclusion, Japanese CLD patients with frailty displayed poorer conditions, both physically and mentally.

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Adverse Health-Related Quality of Life Outcome Despite Adequate Clinical Response to Treatment in Systemic Lupus Erythematosus

Frontiers in Medicine ◽

10.3389/fmed.2021.651249 ◽

2021 ◽

Vol 8 ◽

Author(s):

Alvaro Gomez ◽

Victor Qiu ◽

Arvid Cederlund ◽

Alexander Borg ◽

Julius Lindblom ◽

...

Keyword(s):

Quality Of Life ◽

Clinical Response ◽

Physical Functioning ◽

Standard Therapy ◽

Organ Damage ◽

Health Related Quality ◽

Sf 36 ◽

Related Quality ◽

Health Related

Objective: To determine the prevalence of adverse health-related quality of life (HRQoL) outcomes in patients with SLE who achieved an adequate clinical response after a 52-week long standard therapy plus belimumab or placebo, and identify contributing factors.Methods: We included patients who met the primary endpoint of the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials, i.e., SLE Responder Index 4 (total population: N = 760/1,684; placebo: N = 217/562; belimumab 1 mg/kg: N = 258/559; belimumab 10 mg/kg: N = 285/563). Adverse HRQoL outcomes were defined as SF-36 scale scores ≤ the 5th percentile derived from age- and sex-matched population-based norms, and FACIT-Fatigue scores <30. We investigated factors associated with adverse HRQoL outcomes using logistic regression analysis.Results: We found clinically important diminutions of HRQoL in SLE patients compared with matched norms and high frequencies of adverse HRQoL outcomes, the highest in SF-36 general health (29.1%), followed by FACIT-Fatigue (25.8%) and SF-36 physical functioning (25.4%). Overall, frequencies were higher with increasing age. Black/African American and White/Caucasian patients reported higher frequencies than Asians and Indigenous Americans, while Hispanics experienced adverse HRQoL outcome less frequently than non-Hispanics. Established organ damage was associated with adverse physical but not mental HRQoL outcomes; particularly, damage in the cardiovascular (OR: 2.12; 95% CI: 1.07–4.21; P = 0.032) and musculoskeletal (OR: 1.41; 95% CI: 1.01–1.96; P = 0.041) domains was associated with adverse SF-36 physical component summary. Disease activity showed no impact on HRQoL outcomes. In multivariable logistic regression analysis, addition of belimumab to standard therapy was associated with lower frequencies of adverse SF-36 physical functioning (OR: 0.59; 95% CI: 0.39–0.91; P = 0.016) and FACIT-F (OR: 0.53; 95% CI: 0.34–0.81; P = 0.004).Conclusions: Despite adequate clinical response to standard therapy plus belimumab or placebo, a substantial proportion of SLE patients still reported adverse HRQoL outcomes. While no impact was documented for disease activity, established organ damage contributed to adverse outcome within physical HRQoL aspects and add-on belimumab was shown to be protective against adverse physical functioning and severe fatigue.

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Health-related quality of life and insulin resistance over a 10-year follow-up

Scientific Reports ◽

10.1038/s41598-021-03791-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Nijole Kazukauskiene ◽

Aurelija Podlipskyte ◽

Giedrius Varoneckas ◽

Narseta Mickuviene

Keyword(s):

Quality Of Life ◽

Insulin Resistance ◽

Social Functioning ◽

Physical Functioning ◽

Health Related Quality ◽

Emotional Role ◽

Related Quality ◽

Health Related

AbstractThe aim of the study was to investigate the association between insulin resistance (IR) and health-related quality of life (HRQoL) among citizens of Palanga in a 10-year follow-up. A randomized epidemiological study was performed with 835 subjects. The following data were examined using questionnaires: sociodemographic characteristics, behavioural factors, HRQoL and self-perceived health. Fasting blood samples were drawn from all participants, and biochemical tests were performed for glucose and insulin. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). In subjects with IR, after adjusting for various factors, logistic regression analysis showed that within 10 years, there was a significantly higher chance of deteriorating HRQoL in the areas of physical functioning (odds ratio [OR] = 1.15, p < 0.001), emotional role limitations (OR = 1.07, p = 0.034), social functioning (OR = 1.26, p = 0.004), pain (OR = 1.09, p = 0.005) and general health perception (OR = 1.07, p = 0.022). People with IR have a worse HRQoL, and as they age, they are significantly more likely to have a deterioration in their HRQoL than people without IR in the areas of physical functioning, emotional role limitations, social functioning, pain and general health perception.

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PO-215 The Association of Gait Speed and Quality of Life in Older Adults

Exercise Biochemistry Review ◽

10.14428/ebr.v1i5.9453 ◽

2018 ◽

Vol 1 (5) ◽

Author(s):

Hanxiao Zhu

Keyword(s):

Quality Of Life ◽

Older Adults ◽

Physical Functioning ◽

Gait Speed ◽

The Elderly ◽

Health Related Quality ◽

Sf 36 ◽

Related Quality ◽

Health Related

Objective With aging, the health and self-care ability of the elderly generally decrease, falling into frailty ultimately. In this process, the loss of muscle mass is very obvious, which will result sluggishness, especially in walking speed. This study aimed to assess whether gait speed could be used as a predictor for health-related quality of life in older adults. Methods 368 subjects were recruited from community-dwelling older adults. Gait speed measurements included usual gait speed (UGS) and fast gait speed (FGS), at a distance of 50 meters. Health-related quality of life (HRQoL) was assessed through SF-36 questionnaire. The correlation of gait speed and quality of life was analyzed. Results Gait speed (both UGS and FGS) possessed a closed correlation with the total score of SF-36 questionnaire (r >0.6, P <0.05). Most subcomponent of HRQoL (Physical functioning, role limitations because of physical health problems, social functioning, vitality, and general health perceptions) are related to UGS and FGS, where the correlation coefficient is higher on FGS in Physical functioning, vitality, and general health perception than UGS. Conclusions Gait speed is correlate to health-related quality of life in elderly people. Therefore, in health services for the elderly, we should strengthen the monitoring of gait speed, and take brisk walking as an effective way of exercise.

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