Health-Related Quality of Life in Pediatric Patients with Leukemia in Singapore: A Cross-Sectional Pilot Study

There has been a paradigm shift in health service delivery to a more holistic approach, which considers Quality of Life (QoL) and overall functioning. Health-Related Quality of Life (HRQoL) is a multidimensional construct that encompasses physical functioning as well as psychosocial aspects of emotional and social functioning. This study explored factors related to HRQoL in Asian pediatric patients with leukemia in Singapore. The available variables included: age, treatment duration, household income, gender, ethnicity, religion, diagnosis, and phase of treatment. It is hypothesized that the relationships will be significant. In the current study, there were 60 patients (60% males) with leukemia; their ages ranged from 1 to 21 years (Mean = 8.03, Standard Deviation = 4.55). The hypothesis was partially supported. Age had a significant positive relationship with physical functioning, r(60) = 0.28, p < 0.05, physical health, r(60) = 0.28, p < 0.05, and the total HRQoL score, r(60) = 0.29, p < 0.05. Treatment duration had a positive relationship with school functioning, r(60) = 0.28, p < 0.05. All other correlations were statistically non-significant. The effects of the available psychosocial variables of gender, ethnicity, and religion were examined on scores from the Pediatric Quality of Life Inventory (PedsQL). Ethnicity had a significant effect on social functioning, U = 292.00, p < 0.05, r = 0.3 (medium effect size). Specifically, Chinese (Median = 85.00, n = 33) had significantly higher scores on social functioning than others (Median = 70.00, n = 27). The remaining comparisons were statistically non-significant. The current findings added to QoL research, and provided an impetus for more research in the area of HRQoL for children with leukemia in Singapore.

Download Full-text

Recent Injury and Health-Related Quality of Life in Adolescent Athletes

Journal of Athletic Training ◽

10.4085/1062-6050-44.6.603 ◽

2009 ◽

Vol 44 (6) ◽

pp. 603-610 ◽

Cited By ~ 52

Author(s):

Tamara C. Valovich McLeod ◽

R. Curtis Bay ◽

John T. Parsons ◽

Eric L. Sauers ◽

Alison R. Snyder

Keyword(s):

Quality Of Life ◽

Social Functioning ◽

Physical Functioning ◽

Global Score ◽

Health Related Quality ◽

Adolescent Athletes ◽

Sf 36 ◽

Related Quality ◽

Health Related

Abstract Context: Health-related quality of life (HRQOL) is a global concept that takes into account the physical, psychological, and social domains of health. Determining the extent to which injury affects HRQOL is an important aspect of rehabilitation practice, enabling comparisons of clinical outcomes across different conditions in diverse patient groups. Objective: To examine the extent to which a self-reported recent injury affected HRQOL in adolescent athletes using 2 generic patient self-report scales. Design: Cross-sectional study. Setting: High school classrooms and athletic training facilities. Patients or Other Participants: A convenience sample of uninjured (n = 160) and injured (n = 45) adolescent athletes. Intervention(s): The independent variable was injury status: uninjured versus injured. All participants completed a self-administered brief health status questionnaire and the Short Form–36 Health Survey Questionnaire (SF-36) and Pediatric Outcomes Data Collection Instrument (PODCI) in a counterbalanced manner. Main Outcome Measure(s): Dependent variables included 8 subscale and 2 composite scores of the SF-36 and 5 subscale scores and 1 global score of the PODCI. Group differences were assessed with the Mann-Whitney U test (P ≤ .05) and reported as median and interquartile range. Results: On the SF-36, the injured group demonstrated lower scores (P < .008) for physical functioning, limitations due to physical health problems, bodily pain, social functioning, and the physical composite. On the PODCI, the injured group reported lower scores (P < .01) on the pain and comfort subscale and the global score. Conclusions: Adolescent athletes with self-reported injuries demonstrated lower HRQOL than their uninjured peers. As expected, recent injury affected physical functioning and pain. Social functioning (on the SF-36) and global HRQOL (on the PODCI) also decreased, suggesting that injuries affected areas beyond the expected physical component of health. Clinicians need to recognize the full spectrum of negative influences that injuries may have on HRQOL in adolescent athletes.

Download Full-text

Health-related Quality of Life and Insulin Resistance: a Longitudinal Study

10.21203/rs.3.rs-651299/v1 ◽

2021 ◽

Author(s):

Kazukauskiene Nijole ◽

Podlipskyte Aurelija ◽

Varoneckas Giedrius ◽

Mickuviene Narseta

Keyword(s):

Quality Of Life ◽

Insulin Resistance ◽

Social Functioning ◽

Physical Functioning ◽

General Health ◽

Health Related Quality ◽

Emotional Role ◽

Related Quality ◽

Health Related

Abstract The aim of the study was to investigate insulin resistance (IR) in association with health-related quality of life (HRQoL) among citizens of Palanga in a ten years follow-up. A randomized epidemiological study was performed out for 835 subjects. All study participants were evaluated according to for socio-demographic characteristics, behavioral factors, HRQoL and self-perceived health using questionnaires. Fasting blood samples were draw from all participants and biochemical tests were performed for the glucose, insulin. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). In subjects with IR, after adjusting with various factors, logistic regression analysis showed, that within 10 years, a significantly higher chance of deteriorating HRQoL in the areas of: physical functioning (odss ratio [OR] = 1.15, p < 0.001), emotional role limitations (OR = 1.07, p = 0.034), social functioning (OR = 1.26, p = 0.004), pain (OR = 1.09, p = 0.005) and general health perception (OR = 1.07, p = 0.022). People with IR have a worse HRQoL and as they age, they are significantly more likely to have a deterioration in their HRQoL compared to people without IR in the areas of physical functioning, emotional role limitations, social functioning, pain and general health perception.

Download Full-text

Health-related quality of life and insulin resistance over a 10-year follow-up

Scientific Reports ◽

10.1038/s41598-021-03791-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Nijole Kazukauskiene ◽

Aurelija Podlipskyte ◽

Giedrius Varoneckas ◽

Narseta Mickuviene

Keyword(s):

Quality Of Life ◽

Insulin Resistance ◽

Social Functioning ◽

Physical Functioning ◽

Health Related Quality ◽

Emotional Role ◽

Related Quality ◽

Health Related

AbstractThe aim of the study was to investigate the association between insulin resistance (IR) and health-related quality of life (HRQoL) among citizens of Palanga in a 10-year follow-up. A randomized epidemiological study was performed with 835 subjects. The following data were examined using questionnaires: sociodemographic characteristics, behavioural factors, HRQoL and self-perceived health. Fasting blood samples were drawn from all participants, and biochemical tests were performed for glucose and insulin. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). In subjects with IR, after adjusting for various factors, logistic regression analysis showed that within 10 years, there was a significantly higher chance of deteriorating HRQoL in the areas of physical functioning (odds ratio [OR] = 1.15, p < 0.001), emotional role limitations (OR = 1.07, p = 0.034), social functioning (OR = 1.26, p = 0.004), pain (OR = 1.09, p = 0.005) and general health perception (OR = 1.07, p = 0.022). People with IR have a worse HRQoL, and as they age, they are significantly more likely to have a deterioration in their HRQoL than people without IR in the areas of physical functioning, emotional role limitations, social functioning, pain and general health perception.

Download Full-text

Health-Related Quality of Life Among Vietnamese Breast Cancer Women

Cancer Control ◽

10.1177/1073274819862787 ◽

2019 ◽

Vol 26 (1) ◽

pp. 107327481986278 ◽

Cited By ~ 2

Author(s):

Thanh Huong Tran ◽

Ngoc Linh Trinh ◽

Yen Hoang ◽

Thuy Linh Nguyen ◽

Thu Thao Vu

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Mental Health ◽

Social Functioning ◽

Physical Functioning ◽

Bodily Pain ◽

Health Related Quality ◽

Related Quality ◽

Health Related

The aim of the study was to investigate health-related quality of life among Vietnamese breast cancer women who were treated at National Cancer Hospital, Hanoi, Vietnam, in 2018. Information about physical functioning, Role Physical, Bodily Pain, General Health, vitality, Social Functioning, Role Emotional, and Mental Health of 200 patients with breast cancer was collected through face-to-face interview, using short form-36 questionnaire. We found that the older patients (older than 50 years) had higher score of Mental Health than patients at age 50 and lower ( P < .05). The patients who had better economic status had significantly higher score of Vitality ( P < .05). Patients who were married and living with their partners/husband had better quality of life in General Health ( P<0.05). The patients who had less than 6 months of treatment had better physical functioning score ( P < .05) than the patients who had treatment longer than 6 months. Patients with caring supports from family members had higher scores of Bodily Pain, Social Functioning, Role Emotional, and Mental Health. Patients who have stressed feelings had significantly lower scores of all domains, except for Physical Functioning. The participants who usually stay up late reported lower scores of all components except for Physical Functioning and Role Physical. In conclusion, it is needed to develop psychosocial services, enhance early screening, and diagnose for the women in Vietnam.

Download Full-text

Experiences and barriers to Health-Related Quality of Life following liver transplantation: a qualitative analysis of the perspectives of pediatric patients and their parents

Health and Quality of Life Outcomes ◽

10.1186/1477-7525-8-150 ◽

2010 ◽

Vol 8 (1) ◽

pp. 150 ◽

Cited By ~ 24

Author(s):

David B Nicholas ◽

Anthony R Otley ◽

Rachel Taylor ◽

Anil Dhawan ◽

Susan Gilmour ◽

...

Keyword(s):

Quality Of Life ◽

Liver Transplantation ◽

Qualitative Analysis ◽

Pediatric Patients ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Barriers To Health

Download Full-text

Pain, skin sensations symptoms, and cognitive functioning predictors of health-related quality of life in pediatric patients with Neurofibromatosis Type 1

Quality of Life Research ◽

10.1007/s11136-018-2055-5 ◽

2018 ◽

Vol 28 (4) ◽

pp. 1047-1052 ◽

Cited By ~ 5

Author(s):

James W. Varni ◽

Kavitha Nutakki ◽

Nancy L. Swigonski

Keyword(s):

Quality Of Life ◽

Cognitive Functioning ◽

Neurofibromatosis Type 1 ◽

Pediatric Patients ◽

Neurofibromatosis Type ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Download Full-text

Family Burden and Health Related Quality of Life of HIV Infected Individuals in Madurai, South India

SAARC Journal of Tuberculosis Lung Diseases and HIV/AIDS ◽

10.3126/saarctb.v13i1.16922 ◽

2017 ◽

Vol 13 (1) ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

E. Thiruvalluvan

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Social Functioning ◽

Family Burden ◽

Health Related Quality ◽

Interview Schedule ◽

The Family ◽

Related Quality ◽

Health Related

Introduction: With the advent of Highly Active Antiretroviral Therapy (HAART) in 1996, HIV-infected patients are living longer and are concerned not only with treatment’s ability to extend their life butalso with the quality of the life they are able to lead, because, efficacy of treatment is strongly relatedto meaningful outcome i.e., better Quality of Life. Especially Health related quality of life has not been studied well. Hence, this study was necessitated with the objectives to evaluate Health Related Quality of Life (HRQoL) in HIV infected persons on ART. The secondary objectives were to assess the family burden experienced by the families of HIV infected, and measure influence of family burden on overall quality of life.Methodology: The HIV infected individuals who were started on treatment six months prior to date of interview were considered for the study The SF36 (Short Form with 36 questions) was used to evaluate function and mental Health while Pai and Kapur’s Family Burden Interview schedule was used to assess family burden. Interview schedule was pre-tested on 10 HIV infected individuals for consistency. Data analysis was performed using SPSS version 11 (SPSS inc. Chicago, IL, USA). Pearson product moment Correlation were computed to explore the relationships of SF36 with SLI, Family Burden and BMI. Further, Independent student “t” – test was performed to see the association between HRQoL and gender.Results: Of 91 participants interviewed 51.6% were women. Median age (years) of the respondents was 33. The overall mean score for Physical health was 45.13 SD (12.40) and for Mental health 56.91 SD (15.52). Age of HIV infected persons had significant influence in scores in social functioning (p-value .015), emotional well being scores (.015), and Mental health (.010). Socio life Index was directly related to physical health, mental health, Vitality, social functioning and emotional scores on HRQoL. Physicalhealth score was negatively affected by the Family burden score. Similarly, BMI status of the respondents correlated with Mental health, Body Pain, Vitality and Role emotional scores of HRQoL scale SF 36.Conclusion: Socio Life Index and BMI appear to be the two important predictors of HRQoL. Therefore, special attention may be required to HIV infected persons with lower SLI and BMI. Nutritional supplements, in addition to ART drugs, may be provided to ensure some improvements in physical functioning.SAARC J TUBER LUNG DIS HIV/AIDS, 2016; XIII(1), Page: 1-8

Download Full-text

Health-related quality of life outcomes in pediatric patients with cardiac rhythm devices: a cross-sectional study with case-control comparison

Health and Quality of Life Outcomes ◽

10.1186/s12955-019-1219-5 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 3

Author(s):

Helene Werner ◽

Phaedra Lehmann ◽

Alina Rüegg ◽

Silvia Hilfiker ◽

Karin Steinmann ◽

...

Keyword(s):

Quality Of Life ◽

Physical Health ◽

Pediatric Patients ◽

Healthy Controls ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Cardiac Medication ◽

Disease Specific

Abstract Background Little is known about health-related quality of life (HRQoL) in pediatric patients with cardiac rhythm devices. This study aims to compare self- and proxy-reported HRQoL in patients with pacemaker (PM) and implantable cardioverter-defibrillator (ICD) to that in sex- and age-matched healthy controls and to examine predictors for generic and disease-specific HRQoL. Methods The study included 72 PM and ICD patients (39% females) and 72 sex- and age-matched healthy controls from 3 to 18 years of age. HRQoL data was obtained by the PedsQL 4.0 Generic Core Scales and Pediatric Cardiac Quality of Life Inventory. Medical data was collected retrospectively from medical records. Results Patients had significantly lower self- and proxy-reported generic overall HRQoL and lower physical health than healthy controls, and ICD patients also had lower psychosocial health. On multivariate analyses, generic overall HRQoL and physical health was significantly predicted by current cardiac medication (β = −.39, p = .02 for overall HRQoL, respectively β = −.44, p = .006 for physical health). Disease-specific overall HRQoL was only marginally predicted by child age, device type, and the presence of a structural congenital heart disease (p < .10). Conclusions This study shows that PM and ICD patients have lower HRQoL than healthy controls and that patients who need cardiac medication are seen by their parents at great risk for lower generic overall HRQoL. Our study also indicates a trend towards higher risk for low disease-specific HRQoL in younger patients, ICD patients, and patients with a structural congenital heart disease. Special attention should be given to these patients as they may benefit from a timely clinical evaluation in order to provide supportive interventions.

Download Full-text