scholarly journals An Unusual Breast Mass in a 13-year-old Girl: a Case Report

2021 ◽  
Author(s):  
Tianzhu Long ◽  
Yuzhi Yao ◽  
Quan Shi ◽  
Yuanxuan Cai ◽  
Quan Li ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Benign Breast Disease ◽  
Clinical Course ◽  
Breast Disease ◽  
Intraductal Papilloma ◽  
Case Presentation ◽  
Pathological Subtype ◽  
Cystic Changes ◽  
Left Nipple

Abstract BackgroundIn puberty breast intraductal papilloma was rare, but the pathological changes of intraductal papilloma combined with intraductal fibroadenoma in the duct lumen were even less reported. Herein we reported a case of adolescent benign breast disease that contained the two features of neoplasm in the same duct and discussed its clinical course.Case presentationA 13-year-old adolescent female presented to our hospital with spontaneous bloody discharge of the left nipple. On clinical examination, a 2.5cmx1.5cm mass could be palpable under the left nipple, and a single-hole bloody discharge could be seen by squeezing the mass. Surgical resection of the mass and part of the breast duct was confirmed by postoperative pathology as intraductal papilloma and intracanalicular type fibroadenoma, with cystic changes of ductal epithelium hyperplasia. After 15 months of follow-up, there was no evidence of recurrence.ConclusionsIntraductal fibroadenomatosis may be a new pathological subtype in which multiple histologic characteristics can be seen in the same duct. Surgical resection is the only effective treatment. Its etiology is still unknown, and it remains to be accumulated more cases for further exploration.

scholarly journals Radiological and Clinical Findings of Multiple Cerebellar Liponeurocytoma: A Case Report

2021 ◽  
Vol 8 ◽  
Author(s):  
Shan Wang ◽  
Xiaopei Xu ◽  
Chao Wang
Keyword(s):  
Surgical Resection ◽  
Clinical Course ◽  
Clinical Findings ◽  
Imaging Findings ◽  
Case Presentation ◽  
Rare Benign Tumor ◽  
History Of ◽  
Cerebellar Liponeurocytoma ◽  
Magnetic Resonance Imaging Mri

Background: Cerebellar liponeurocytoma is an extremely rare benign tumor which generally occurs in cerebellum and is almost always solitary. Multifocal cerebellar liponeurocytoma is exceedingly rare, only 8 cases has been reported so far. Herein we present the 9th case of multifocal cerebellar liponeurocytoma in a 70-year-old woman with the complete clinical course and comprehensive imaging findings.Case Presentation: A 70-year-old woman presented with a history of intermittent headache for 5 years. Computed tomography (CT) and magnetic resonance imaging (MRI) of the brain have been performed and suggested a diagnosis of teratoma based on the imaging findings. After the surgical resection of the lesion, histopathological and immunohistochemical analyses revealed neuronal, glial, and lipomatous components and confirmed the diagnosis of multifocal cerebellar liponeurocytoma after surgical resection. During the 2-year follow-up period, the patient showed no signs of recurrence or metastasis.Conclusion: We described the radiological characteristics and clinical course of an exceedingly rare case of multifocal cerebellar liponeurocytoma in the cerebellar vermis and temporal lobe. The clear multifocality makes this case unusual.

scholarly journals Citalopram intoxication in four week old infant

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jo-Anne Janson ◽  
Arthur T. M. Wasylewicz ◽  
Marianne Eijkemans ◽  
Marieke Kerskes
Keyword(s):  
Case Report ◽  
Cardiac Rhythm ◽  
Clinical Course ◽  
Screening Methods ◽  
Pharmacokinetic Data ◽  
Pediatric Practice ◽  
Case Presentation ◽  
Young Infants ◽  
First Case

Abstract Background In contrast to intoxications in toddlers which can be due to accidental ingestions, many intoxications in infants are due to medication errors. To our knowledge, this is the first case report of a citalopram intoxication in an infant, and may offer new insight on possible screening methods for intoxication as well as pharmacokinetics of citalopram in small infants. Case presentation This case report describes an unintentional citalopram intoxication in a 4 week old infant due to a vitamin D drops ‘look alike’ error. The infant showed extreme jitteriness and opisthotonus at presentation, as well as prolonged signs of gastro-oesophageal reflux. No cardiac rhythm disturbances or convulsions were seen. The clinical course combined with Finnegan scores was correlated to and supported by pharmacokinetic and pharmacokinetic data of citalopram in the patient. Conclusions Using Finnegan scores in general pediatric practice could help objectify follow-up of acute intoxications in young infants with neurological symptoms.

Clinical presentation, natural history and outcomes of intramedullary spinal cord cavernous malformations

2019 ◽  
Vol 90 (6) ◽  
pp. 695-703 ◽  
Author(s):  
Anshit Goyal ◽  
Lorenzo Rinaldo ◽  
Redab Alkhataybeh ◽  
Panagiotis Kerezoudis ◽  
Mohammed Ali Alvi ◽  
...  
Keyword(s):  
Natural History ◽  
Surgical Resection ◽  
Clinical Presentation ◽  
Clinical Course ◽  
Univariate Analysis ◽  
Case Series ◽  
Intramedullary Spinal Cord ◽  
Cavernous Malformations ◽  
Increased Risk

ObjectiveThere is a paucity of literature investigating the clinical course of patients with spinal intramedullary cavernous malformations (ISCMs). We present a large case series of ISCMs to describe clinical presentation, natural history and outcomes of both surgical and conservative management.MethodsWe retrospectively reviewed the clinical course of patients diagnosed with ISCMs at our institution between 1995 and 2016. Haemorrhage was defined as clinical worsening in tandem with imaging changes visualised on follow-up MRI. Outcomes assessed included neurological status and annual haemorrhage rates.ResultsA total of 107 patients met inclusion criteria. Follow-up data were available for 85 patients. While 21 (24.7%) patients underwent immediate surgical resection, 64 (75.3%) were initially managed conservatively. Among this latter group, 16 (25.0%) suffered a haemorrhage during follow-up and 11 (17.2%) required surgical resection due to interval bleeding or neurological worsening. The overall annual risk of haemorrhage was 5.5% per person year. The rate among patients who were symptomatic and asymptomatic on presentation was 9.5% and 0.8%, respectively. Median time to haemorrhage was 2.3 years (0.1–12.3). Univariate analysis identified higher ISCM size (p=0.024), history of prior haemorrhage (p=0.013) and presence of symptoms (p=0.003) as risk factors for subsequent haemorrhage. Multivariable proportional hazards analysis revealed presence of symptoms to be independently associated with haemorrhage during follow-up (HR 9.39, CI 1.86 to 170.8, p=0.013).ConclusionLarge, symptomatic ISCMs appear to be at increased risk for subsequent haemorrhage. Surgery may be considered in such lesions to prevent rebleeding and subsequent neurological worsening.

Synchronous Pancreatic and Pulmonary Metastases from Solitary Fibrous Tumor of the Pleura: Report of a Case

2017 ◽  
Vol 103 (1_suppl) ◽  
pp. S9-S11 ◽  
Author(s):  
Nicola Tamburini ◽  
Nicolò Fabbri ◽  
Gabriele Anania ◽  
Pio Maniscalco ◽  
Francesco Quarantotto ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Pulmonary Metastases ◽  
Clinical Course ◽  
Good Prognosis ◽  
Pancreatic Metastasis ◽  
Case Presentation ◽  
First Case ◽  
Fibrous Tumor ◽  
Uncommon Tumor

Introduction Solitary fibrous tumor of the pleura is an uncommon tumor with an indolent course and a good prognosis after surgical resection. However, the tumor occasionally follows an unpredictable clinical course and malignant transformation has been reported to increase the rate of local recurrence. Solitary extrathoracic metastasis from solitary fibrous tumor of the pleura is an uncommon finding. Case Presentation In this case report we present the first case of a synchronous single pulmonary and pancreatic metastasis treated with minimally invasive surgery. Conclusions Pancreatic recurrence should be considered in the postoperative follow-up in patients with solitary fibrous tumor of the pleura.

Radiation-Induced Breast Cancer: Long-Term Follow-up of Radiation Therapy for Benign Breast Disease

1993 ◽  
Vol 85 (20) ◽  
pp. 1679-1685 ◽  
Author(s):  
Anders Mattsson ◽  
Bengt-Inge Rudén ◽  
Per Hall ◽  
Nils Wilking ◽  
Lars Erik Rutqvist
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Long Term Follow Up ◽  
Radiation Induced

scholarly journals Are High Doses of Corticosteroids Protective in COVID-19 Patient With Panhypopituitarism?

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A574-A574
Author(s):  
Tina Ticinovic Kurir ◽  
Maja Mizdrak ◽  
Mladen Krnić
Keyword(s):  
Clinical Course ◽  
Protective Role ◽  
Pathophysiological Mechanism ◽  
Oxygen Supplementation ◽  
Case Presentation ◽  
X Ray ◽  
High Doses ◽  
Endothelium Damage ◽  
The Right

Abstract Introduction: Clinical course of COVID-19 infection is diverse and the best therapeutical guidelines are still lacking. Case Presentation: We present a case of 73 year old male COVID-19 positive patient. In 2017 transnasal hypophysectomy was performed due to prolactinoma. He receives therapy (hydrocortisone 20 + 10 mg/day, levothyroxine 75/50 µg/day, bromocriptine 2.5 mg twice/day). He suffers also from arterial hypertension. Present illness started with intensive dry cough, fever (37.5◦C), diarrhoea and loss of smell. On the first day patient was febrile up to 38.4◦C and later afebrile. Laboratory parameters showed abnormalities in several parameters: D-dimers 13.45 (RR:< 0.50) mg/L, creatinine 110 (49-90) µmol/L, ALT 73 (12-28) U/L, LDH 531 (25-241) U/L, creatine kinase 549 (<177) U/L, GGT 277 (9-35) U/L, CRP 38 (<5 mg/L), sedimentation rate 40 (5-28) mm/3.6ks, procalcitonine 0.07 (<0.05) ng/ml, sodium 128 (137-146) mmol/L, hs-TroponinT 18 (< 14) ng/L, neutrophils 8.56 (2.06-6.49 x109/L), lymphocytes 0.52 (1.19-3.35 x109/L) and pO2 6.1 (11.0-14.4) kPa. At the admission X-ray showed normal presentation, while four days later on the right side pneumonia was noticed as spotty inhomogeneous shading. He was treated with azithromycin, hydrocortisone (50 mg twice/day) and oxygen supplementation. At the beginning of hospitalization he was addicted to O2 10-12 L/min. After 22 days of hospitalization he was discharged without any symptom but with still positive SARS-CoV2 swabs. After a 30 days of follow-up, his swabs are now negative with no laboratory abnormalities. In the meantime, his two brothers, born in 1945 and 1940 died due to COVID-19 infection. They did not receive substitutional corticosteroid therapy. Conclusion: The main pathophysiological mechanism of infection is explained by cytokine storm. Hypercytokinemia causes myelosuppression and vascular endothelium damage. Corticosteroids are potent anti-inflammatory agents. High-doses of corticosteroids might beneficially modulate the host immune response to SARS-CoV2 virus and have protective role in this patient.

scholarly journals Idiopathic Granulomatous Mastitis- Challenges of Diagnosis and Treatment

2017 ◽  
Vol 28 (1) ◽  
pp. 14-16
Author(s):  
Sharmistha Roy ◽  
Samiron Kumar Mondal ◽  
Md Ruhul Amin ◽  
Indira Sufia Khan
Keyword(s):  
Benign Breast Disease ◽  
Clinical Presentation ◽  
Surgical Intervention ◽  
Breast Disease ◽  
Diagnosis And Treatment ◽  
Incisional Biopsy ◽  
Unknown Aetiology ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis

Idiopathic Granulomatous Mastitis (IGM) is a benign breast disease. Owing to its unknown aetiology, rareness,variation of presentation - diagnosis and treatment is still a challenge. This is a retrospective review of clinical presentation and investigation finding of all patients histopathologically diagnosed as IGM from February 2010 to January 2014. Treatment outcome and follow up information were recorded. 6(42%) patient presented with breast abscess, 5(35.7%) patient had features of mastitis without abscess, 3(21.4%) patient had painful firm to hard lump. Diagnosis confirmed by excisional/ incisional biopsy. 9(64%) patients needed more than one surgical intervention. Mean follow up period was 27months. Standardization and optimization of treatment is yet to be achieved.Medicine Today 2016 Vol.28(1): 14-16

Long-term follow-up of patients with biopsy-proven benign breast disease

Maturitas ◽  
1988 ◽  
Vol 10 (4) ◽  
pp. 354
Author(s):  
H-B Ris ◽  
U Niederer ◽  
H Stirnemann ◽  
JE Doran ◽  
A Zimmermann
Keyword(s):  
Benign Breast Disease ◽  
Breast Disease ◽  
Long Term Follow Up
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