Elective Neck Dissection can Improve the Overall Survival and Cancer-Specific Survival of T3cN0M0 Glottic Squamous Cell Cancer

Abstract How to treat clinically node-negative (cN0) neck in larynx squamous cell cancer (LSCC) has been subject to considerable discussion. The role of elective neck dissection (END) in patients with T3 glottic squamous cell cancer (GSCC) with cN0 is remain unclear. The objective of this study is to elucidate the role of END in improve the outcome of T3cN0M0 GSCC. Patients with T3cN0M0 GSCC in the Surveillance, Epidemiology, and End Results database (SEER) from 2004 to 2015 were extracted and stratified into END and Non-END cohorts, we found that only 22–58% T3cN0M0 GSCC were performed with END. After Propensity score matching (PSM), END cohort had better overall survival (OS) (median survival time: 93 vs 40 months, respectively; p < 0.0001) and cancer-specific survival (CSS) (HR 0.40, 95%CI 0.26 to 0.64, p = 0.0012) than non-END cohort. In addition, Subgroup analysis also indicated END cohort had better OS or CSS than non-END cohort.This study demonstrated that in patients with T3cN0M0 GSCC, END significantly associated with better survival outcomes compared with non-END.

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Neck Dissection in Relation With Disease-Free, Disease-Specific, and Overall Survival of Patients With Squamous Cell Cancer of the Oral Cavity

Journal of Craniofacial Surgery ◽

10.1097/scs.0000000000001023 ◽

2014 ◽

Vol 25 (6) ◽

pp. 1992-1997 ◽

Cited By ~ 8

Author(s):

Georgios Koloutsos ◽

Konstantinos Vahtsevanos ◽

Athanassios Kyrgidis ◽

Nikolaos Kechagias ◽

Stefanos Triaridis ◽

...

Keyword(s):

Overall Survival ◽

Oral Cavity ◽

Neck Dissection ◽

Squamous Cell ◽

Squamous Cell Cancer ◽

Cell Cancer ◽

Disease Free ◽

Disease Specific

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Improving Survival of T3cN0M0 Glottic Squamous Cell Cancer With Elective Neck Dissection

The Laryngoscope ◽

10.1002/lary.29973 ◽

2021 ◽

Author(s):

Zhimou Cai ◽

Lin Chen ◽

Jingwei Zhang ◽

Yihui Wen ◽

Wenbin Lei

Keyword(s):

Neck Dissection ◽

Squamous Cell ◽

Squamous Cell Cancer ◽

Cell Cancer ◽

Elective Neck Dissection

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Planned neck dissection after chemoradiotherapy in advanced oropharyngeal squamous cell cancer: The role of US, MRI and FDG-PET/TC scans to assess residual neck disease

Journal of Cranio-Maxillofacial Surgery ◽

10.1016/j.jcms.2014.06.023 ◽

2014 ◽

Vol 42 (8) ◽

pp. 1834-1839 ◽

Cited By ~ 12

Author(s):

Raul Pellini ◽

Valentina Manciocco ◽

Mario Turri-Zanoni ◽

Antonello Vidiri ◽

Giuseppe Sanguineti ◽

...

Keyword(s):

Neck Dissection ◽

Squamous Cell ◽

Fdg Pet ◽

Squamous Cell Cancer ◽

Cell Cancer ◽

Neck Disease

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Faculty Opinions recommendation of Role of narrow-band imaging and high-definition television in the surveillance of head and neck squamous cell cancer after chemo- and/or radiotherapy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.6552956.6685054 ◽

2010 ◽

Author(s):

Andreas Dietz

Keyword(s):

Head And Neck ◽

Squamous Cell ◽

Narrow Band ◽

Squamous Cell Cancer ◽

Narrow Band Imaging ◽

Cell Cancer ◽

High Definition ◽

High Definition Television ◽

Neck Squamous Cell Cancer

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Low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy

Scientific Reports ◽

10.1038/s41598-021-86019-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yu-Chieh Ho ◽

Yuan-Chun Lai ◽

Hsuan-Yu Lin ◽

Ming-Hui Ko ◽

Sheng-Hung Wang ◽

...

Keyword(s):

Overall Survival ◽

Cancer Patients ◽

Squamous Cell ◽

Squamous Cell Cancer ◽

Performance Status ◽

Cell Cancer ◽

Esophageal Squamous Cell Cancer ◽

Lymphocyte Ratio ◽

Cardiac Dose

AbstractWe aimed to determine the prognostic significance of cardiac dose and hematological immunity parameters in esophageal cancer patients after concurrent chemoradiotherapy (CCRT). During 2010–2015, we identified 101 newly diagnosed esophageal squamous cell cancer patients who had completed definitive CCRT. Patients' clinical, dosimetric, and hematological data, including absolute neutrophil count, absolute lymphocyte count, and neutrophil-to-lymphocyte ratio (NLR), at baseline, during, and post-CCRT were analyzed. Cox proportional hazards were calculated to identify potential risk factors for overall survival (OS). Median OS was 13 months (95% confidence interval [CI]: 10.38–15.63). Univariate analysis revealed that male sex, poor performance status, advanced nodal stage, higher percentage of heart receiving 10 Gy (heart V10), and higher NLR (baseline and follow-up) were significantly associated with worse OS. In multivariate analysis, performance status (ECOG 0 & 1 vs. 2; hazard ratio [HR] 3.12, 95% CI 1.30–7.48), heart V10 (> 84% vs. ≤ 84%; HR 2.24, 95% CI 1.26–3.95), baseline NLR (> 3.56 vs. ≤ 3.56; HR 2.36, 95% CI 1.39–4.00), and follow-up NLR (> 7.4 vs. ≤ 7.4; HR 1.95, 95% CI 1.12–3.41) correlated with worse OS. Volume of low cardiac dose and NLR (baseline and follow-up) were associated with worse patient survival.

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