scholarly journals Correlation Between Carotid Intima Media Thickness and Serum Uric Acid, Results From 15843 Subjects in 2016-2020

2021 ◽  
Author(s):  
Mingzhu Ma ◽  
Liangxu Wang ◽  
Xiaoni Zhong ◽  
Li Zhong ◽  
Rong Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Carotid Artery ◽  
Serum Uric Acid ◽  
Reference Group ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Men And Women ◽  
Media Thickness ◽  
Blood Uric Acid

Abstract Objective: Uric acid is thought to be associated with the occurrence of atherosclerosis, which is closely related to cardio-cerebrovascular disease. However, the present study examined serum uric acid (SUA) and its correlation with carotid intima-media thickness (CIMT), which is a major issue. The purpose of this paper is to examine serum uric acid concentration and its correlation with carotid artery atherosclerosis according to age and sex groups.Methods: Individuals who underwent physical examinations at the First Affiliated Hospital of Chongqing Medical University from 2016 to 2020 were selected. The physical examination information of the subjects was recorded, and biochemical indexes such as blood uric acid levels were collected. The intima media thickness of the carotid artery was measured by ultrasound. Using traditional atherosclerosis risk factors as adjustment variables, the association between blood uric acid levels and atherosclerosis was assessed by logistic regression analysis.Results: A total of 15,843 subjects (73.90% male) were included, with an average age of 52±12 (20-92) years. The prevalence of CIMT thickened was 9.51%, and the plaque prevalence was 28.59%. Univariate analysis results showed that there were significant differences in CIMT thickening and plaque occurrence among different SUA level groups in both men and women (P<0.0001). After adjustment for conventional cardiovascular risk factors, increased SUA levels were significantly associated with an increased risk of CIMT thickening (male: ≤220 μmol/L as the reference group, 220-290 μmol/L: OR=1.591, 95% CI: 1.069-2.367; 290-360 μmol/L: OR=1.65, 95% CI: 1.127-2.415;360-430 μmol/L: OR=1.634, 95% CI: 1.116-2.393; >430 μmol/L: OR=1.857, 95% CI: 1.264-2.73;P < 0.05. female: ≤210 μmol/L as the reference group, 260-310 μmol/L: OR=1.419, 95% CI: 1.059-1.901; 310-360 μmol/L: OR=1.432, 95% CI: 1.048-1.957; >360 μmol/L: OR=1.557, 95% CI: 1.113-2.177; P < 0.05). Correlation analysis in each age subgroup showed that CIMT was significantly associated with SUA in men ≥60 years old and women 45-60 years old and ≥60 years old (male: ≤220 μmol/L as the reference group, >430 μmol/L: OR=1.972, 95% CI: [1.2,3.238]. female: ≤210 μmol/L as the reference group, >360 μmol/L (45-60 years old): OR=1.77, 95% CI:[1.107,2.832]; > 360 μmol/L (≥60 years old), OR = 1.65, 95% CI: [1.067, 2.551]. P < 0.05).Conclusions: In both men and women, increased SUA levels are closely associated with thickened CIMT, which is associated with a higher risk of cardio-cerebrovascular disease. The age at which this association was observed in women was lower than in men, and whether this result is due to changes in hormone levels before and after menopause remains to be prospectively studied.

Serum uric acid in asymptomatic adults is weakly associated with carotid artery FDG uptake but not intima-media thickness

2018 ◽  
Vol 27 (5) ◽  
pp. 1537-1546 ◽  
Author(s):  
Young Seok Cho ◽  
Ji Hoon Bae ◽  
Seung Hwan Moon ◽  
Seung Hyup Hyun ◽  
Joon Young Choi ◽  
...  
Keyword(s):  
Uric Acid ◽  
Carotid Artery ◽  
Serum Uric Acid ◽  
Intima Media Thickness ◽  
Fdg Uptake ◽  
Media Thickness

scholarly journals Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246416
Author(s):  
Mingzhu Ma ◽  
Liangxu Wang ◽  
Wenjing Huang ◽  
Xiaoni Zhong ◽  
Longfei Li ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Subgroup Analysis ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Meta Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

Objective Recently, increasing epidemiological evidence has shown that there is a correlation between serum uric acid level (SUA) and carotid intima-media thickness (CIMT). This paper explored the relationship between them through meta-analysis. Methods PubMed, Cochrane Library, EMBASE, Web of Science and Google Scholar were searched to obtain literature. The keywords used to retrieve the literature were carotid intima thickness, intima-media thickness, carotid atherosclerosis, carotid stenosis, carotid artery, uric acid, blood uric acid, and hyperuricaemia. The retrieval time was from the establishment of the database through July 2020. Stata15.0 and RevMan5.3 software were used for statistical analysis. The standardized mean difference (SMD) and 95% confidence interval (95% CI) were calculated by a random effect model to estimate the correlation. Publication bias was assessed using the Begg and Egger tests. The stability of these results was evaluated using sensitivity analyses. Results Fifteen studies were included with a total sample size of 11382, including 7597 participants in the high uric acid group and 3785 in the control group, on the basis of the inclusion and exclusion criteria. According to the evaluation of the JBI scale, the literature was of high quality. The average age ranged from 42 to 74. Meta-analysis showed that CIMT in the high uric acid group was significantly higher than that in the control group (SMD = 0.53, 95% CI: [0.38, 0.68]), and the difference was significant (z = 6.98, P < 0.00001). The heterogeneity among the 15 articles was obvious (I2 = 89%, P < 0.00001). Subgroup analysis by disease status illustrated a positive relationship between SUA and CIMT in healthy people and people with diseases. SUA was shown to be positively correlated with CIMT in people aged 45–60 years and ≥60 years by subgroup analysis by age. SUA was also found to be positively correlated with CIMT in a population with BMI>24 kg/m2 by subgroup analysis by BMI. In addition, subgroup analysis of other risk factors for CIMT, including TC, SBP, DBP, triglycerides, and LDL-C, all showed a positive correlation between SUA and CIMT. Conclusions There is a significant correlation between serum uric acid level and carotid intima-media thickness, and a high concentration of serum uric acid is related to carotid artery intima-media thickness.

scholarly journals Effect of uric acid serum levels on carotid arterial stiffness and intima-media thickness: A high resolution Echo-Tracking Study

2019 ◽  
Vol 89 (1) ◽  
Author(s):  
Francesco Antonini-Canterin ◽  
Concetta Di Nora ◽  
Marco Pellegrinet ◽  
Olga Vriz ◽  
Salvatore La Carrubba ◽  
...  
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Carotid Artery ◽  
Arterial Stiffness ◽  
Serum Uric Acid ◽  
Intima Media Thickness ◽  
Stiffness Index ◽  
Artery Stiffness ◽  
Echo Tracking ◽  
Carotid Arterial

Serum uric acid (UA) has been shown to be a predictor of cardiovascular (CV) morbidity and mortality, and it may play a role in the pathogenesis of CV disease affecting vascular structure and function. However, there is limited evidence of its specific association with carotid artery stiffness and structure. The aim of our study was to evaluate whether UA is associated with early signs of atherosclerosis, namely local carotid arterial stiffness and intima-media thickening. We evaluated 698 consecutive asymptomatic patients, referred to the Cardiovascular Department for risk factors evaluation and treatment. All patients underwent carotid artery ultrasonography with measurement of common carotid intima-media thickness (IMT) and echo-tracking carotid artery stiffness index Beta. Patients with hyperuricemia (defined as serum uric acid ≥7 mg/dL in men and ≥6 mg/dL in women) had higher IMT (0.97±0.22 vs 0.91±0.18, p<0.001) and stiffness index Beta (8.3±3.2 vs 7.5±2.7, p=0.005). UA levels correlated with both IMT (r=0.225; p<0.001) and stiffness index Beta (r=0.154; p<0.001); the correlations were statistically significant in males and females. In a multivariate model which included age, arterial pressure, serum glucose and LDL-cholesterol, serum UA emerged as an independent explanatory variable of IMT and stiffness index Beta. Carotid IMT and local arterial stiffness are related to UA independently of established CV risk factors; UA may play a role in the early development of atherosclerosis.

Correlation between Serum Uric Acid and Carotid Intima-Media Thickness in Korean Women

2019 ◽  
Vol 9 (1) ◽  
pp. 102-107
Author(s):  
Jiin Jung ◽  
Sungmoon Cho ◽  
Deokhyun Shin ◽  
Jongwoo Kim ◽  
Seon Yeong Lee ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Korean Women ◽  
Media Thickness

scholarly journals Relation between serum uric acid and carotid intima-media thickness in healthy postmenopausal women

2007 ◽  
Vol 2 (1) ◽  
pp. 19-23 ◽  
Author(s):  
T. Montalcini ◽  
G. Gorgone ◽  
C. Gazzaruso ◽  
G. Sesti ◽  
F. Perticone ◽  
...  
Keyword(s):  
Uric Acid ◽  
Postmenopausal Women ◽  
Serum Uric Acid ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

scholarly journals Carotid Intima–Media Thickness and Markers of Brain Health in a Biracial Middle-Aged Cohort: CARDIA Brain MRI Sub-study

2019 ◽  
Vol 75 (2) ◽  
pp. 380-386 ◽  
Author(s):  
Pavla Cermakova ◽  
Jie Ding ◽  
Osorio Meirelles ◽  
Jared Reis ◽  
Dorota Religa ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
Carotid Artery ◽  
Gray Matter ◽  
Carotid Arteries ◽  
White Matter Hyperintensities ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Total Brain

Abstract Background We investigated whether carotid intima–media thickness is associated with measures of cerebral blood flow (CBF), white matter hyperintensities, and brain volume in a biracial cohort of middle-aged individuals. Methods We performed a cross-sectional cohort study based on data from a multicenter, population-based study Coronary Artery Risk Development in Young Adults. Using linear and logistic regression, we estimated the association of the composite intima–media thickness measured in three segments of carotid arteries (common carotid artery, carotid artery bulb, and internal carotid artery) with volume (cm3) and CBF (mL/100 g/min) in the total brain and gray matter as well as volume of white matter hyperintensities (cm3). Results In the analysis, 461 participants (54% women, 34% African Americans) were included. Greater intima–media thickness was associated with lower CBF in gray matter (β=−1.36; p = .04) and total brain (β=−1.26; p = .04), adjusting for age, sex, race, education, and total brain volume. The associations became statistically nonsignificant after further controlling for cardiovascular risk factors. Intima–media thickness was not associated with volumes of total brain, gray matter, and white matter hyperintensities. Conclusions This study suggests that lower CBF in middle age is associated with markers of atherosclerosis in the carotid arteries. This association may reflect early long-term exposure to traditional cardiovascular risk factors. Early intervention on atherosclerotic risk factors may modulate the trajectory of CBF as people age and develop brain pathology.

scholarly journals POS0528 SCORES OF CARDIOVASCULAR RISK CALCULATORS AS PREDICTORS OF EARLY ATHEROSCLEROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 498.1-498
Author(s):  
E. Gerasimova ◽  
T. Popkova ◽  
D. Gerasimova ◽  
S. Glukhova ◽  
E. Nasonov ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Carotid Artery ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Atherosclerotic Plaques ◽  
Cvd Risk ◽  
Media Thickness ◽  
Traditional Risk Factors ◽  
Early Atherosclerosis

Background:Rheumatoid arthritis (RA) is a systemic inflammatory disease leading to significant increase in cardiovascular morbidity and mortality. Development of cardiovascular diseases (CVD) in RA patients is associated with the accumulation of traditional risk factors and immunological disorders. Carotid Artery Doppler Ultrasound (DUS) Exam is the gold standard to identify early atherosclerosis.Objectives:To evaluate the cardiovascular risk and analyze its relationship with detection of early carotid artery atherosclerotic lesion in patients with rheumatoid arthritis (RA).Methods:One hundred and nine RA patients (female/male 93/16), aged 45 to 60 without established CVD were included in the study. The median age was 52 [48; 54] years, duration of RA was 120 [36; 204] months, DAS28 was 4,7 [3,5; 5,6] points. 54% (n=59) of patients received methotrexate (median dose 20 [15;27]mg/week), 12% - leflunomide (20mg/day), 12% - sulfasalazine (2000mg/day), 40% - glucocorticoids (median dose 4 [2;8]mg/day), 44% - non-steroidal anti-inflammatory drugs. None of study participants had biologics or statins in their therapeutic regiments at the time of inclusion. CVD risk was calculated with mSCORE, RRS, ASSIGN, QRISK3, ERS-RA scales and results of Carotid Artery DUS imaging in all patients.Results:Traditional risk factors were highly among RA patients without CVD, including: arterial hypertension - in 73%, dyslipidemia - 68%, overweight - 53%, family history of CVD - 43% and smoking - 39% patients. A combination of three traditional risk factors was found in 60% of patients with RA, and combination of two – in 25%. High risk was found in 5, 5, 14, 6, and 38% of patients according to mSCORE, RRS, ASSIGN, QRISK3, ERS-RA scales, respectively. Carotid atherosclerotic plaques were found in 30% of patients, more often in men (48%) than in women (28%, p=0,049), with similar prevalence regardless RA activity or stage od disease. Positive correlations of carotid intima-media thickness were established with scores of all CVD risk calculators: mSCORE (R = 0,50), RRS (R = 0,40), ASSIGN (R = 0,40), QRISK3 (R = 0,36), ERS-RA (R = 0,26), p <0,05 in all cases, as well as with age (R = 0,41; p = 0,04), the level of total cholesterol (R = 0,23; p = 0,01), systolic blood pressure (R = 0,66; p = 0,02), diastolic blood pressure (R = 0,33; P = 0,03), erythrocyte sedimentation rate (R = 0,26; p = 0,04), IL-6 levels (R = 0,65; p = 0,01). The sensitivity and specificity of the CVR algorithms in prognostication of atherosclerotic carotid artery lesions were 73 and 67% for mSCORE, 64 and 63% for RRS, 64 and 56% for ASSIGN, 73 and 49% for QRISK3, respectively, p<0.05 in all cases, 67 and 50% for ERS-RA, p=0,06.Conclusion:RRS, mSCORE, ASSIGN, QRISK 3 calculators equally predicted the presence of carotid atherosclerotic plaques in RA patients. The optimal ratio of specificity and sensitivity is shown for the mSCORE scale. Stratification of CVR in RA patients should include assessment of the carotid intima-media thickness. mSCORE calculation and carotid intima-media thickness were the most informative methods identify CVR assessment in RA patients.Disclosure of Interests:None declared

scholarly journals Doppler Ultrasound Study on the Effects of Different Blood Uric Acid Levels on the Carotid Artery Intima-media Thickness in Patients with Gout

2021 ◽  
Author(s):  
Wantai Dang ◽  
Jing Hu ◽  
Hui Luo ◽  
Danling Luo ◽  
Xiaohui Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Function ◽  
Uric Acid ◽  
Carotid Artery ◽  
Carotid Plaque ◽  
Intima Media Thickness ◽  
Secondary Hypertension ◽  
Disease Course ◽  
Media Thickness ◽  
Blood Routine

Abstract Objective : Doppler ultrasonography is used to study the effects of different serum uric acid (SUA) levels in primary gout (PG) on the carotid artery intima-media thickness (CIMT) and its risk factors and to provide clinical evidence for early prevention and treatment of systematic gout damage. Methods: We obtained information of 237 patients with PG (intermittent period) and estimated the association between gout and common carotid artery intima-media thickness (CCAIMT), carotid plaque formation, and blood flow resistance index (RI)) using binary logistic regression. Results: The CCAIMT of patients with PG was significantly correlated with different SUA levels, age, course of the disease, blood routine laboratory parameters etc ( P < 0.05). The CCAIMT of patients with PG combined with the tophi, secondary hypertension, or diabetes group was significantly different from that in the uncombined group ( P < 0.05). The age, disease course, body mass index (BMI), blood routine indexes, liver function, renal function, and lipid metabolism-related indexes of patients with gout combined with the carotid plaque group and without the carotid plaque group were significantly different ( P < 0.05). Age (OR, 95% CI = 1.136, 1.073-1.202), disease course (OR, 95% CI = 1.236, 1.084-1.410), and low-density lipoprotein cholesterol (LDL-C) (OR, 95% CI= 6.982, 2.460-19.816) were risk factors for CCAIMT of more than 0.0858cm, whereas SUA (OR, 95% CI = 0.994, 0.988-0.999) and Lymphocyte percentage (LY%) (OR, 95% CI = 0.842, 0.723-0.980) were protective factors. Age was a risk factor for carotid plaque (OR, 95% CI = 1.137, 1.071-1.207), and SUA was a protective factor (OR, 95% CI = 0.992, 0.986-0.998). Moreover, secondary hypertension (OR, 95% CI = 3.496, 1.442-8.479), PLT (OR, 95% CI = 1.005, 1.001-1.010), and SUA (OR, 95% CI = 1.003, 1.000-1.005) were risk factors for common carotid artery RI of ≥ 0.7 in patients with gout. Conclusion: Age, disease course, blood routine indexes, renal function, and lipid metabolism of patients with gout with different SUA levels were closely related to carotid intima-media diseases. Age, disease course, and LDL-C were the risk factors for carotid artery intima-media lesions in patients with PG, whereas SUA and LY% might be protective factors.

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