Studying the Association Between Breast Cancer and Renal Cell Carcinoma

Abstract Purpose: There are case reports of patients with both primary breast cancer (BC) and renal cell carcinoma (RCC). We explore the association between these two malignancies using SEER population data and our institutional records.Methods: We studied the association between BC and RCC in the 2000-2016 Surveillance, Epidemiology and End Results (SEER) database. We then reviewed our hospital records of patients with both BC and RCC and collected information including personal and family history of cancers, genetic testing, and patient outcomes.Results: Of the 813,477 females diagnosed with BC in the SEER database, 1,914 later developed RCC. The risk of developing RCC was significantly increased within the first six months, 7-12 months, and 1-5 years following BC diagnosis with standardized incidence ratios (SIRs) of 5.08 (95% CI, 4.62- 5.57), 2.09 (95% CI, 1.8-2.42), and 1.15 (95% CI, 1.06-1.24), respectively. Of 56,200 females with RCC, 1,087 later developed BC. The risk of developing BC following RCC was elevated within the first six months (SIR of 1.45 [95% CI, 1.20-1.73]). For our hospital patients, 437 had both BC and RCC. 427 (97.71%) were female, and 358 (81.92%) were white, and breast cancer was diagnosed before RCC in 246 (61.5%) patients. There were 15 germline mutations in those with genetic testing. Conclusion:Our findings suggest that BC patients are at higher risk of developing RCC and vice versa. BC tended to precede RCC, and patients frequently had personal histories of other malignancies and a family history of cancer, particularly BC.

Download Full-text

CHEK2 mutation in renal cell carcinoma (RCC): Single center experience.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.6_suppl.480 ◽

2017 ◽

Vol 35 (6_suppl) ◽

pp. 480-480

Author(s):

Joanna Huszno ◽

Magdalena Mazur ◽

Elzbieta Nowara ◽

Ewa Grzybowska

Keyword(s):

Breast Cancer ◽

Renal Cell Carcinoma ◽

Family History ◽

Cell Carcinoma ◽

Renal Cancer ◽

Renal Cell ◽

Clear Cell ◽

Chek2 Mutation ◽

Mutation Carriers ◽

Cell Renal Cancer

480 Background: Renal cell cancer (RCC) accounts for about 4% of all the adult malignancies. RCC occurs in both sporadic and heritable forms. Genetic mutations have been identified as the cause of inherited cancer risk in 1% to 2% of RCC cases overall. In some studies, variant I157T of CHEK2 gene were found to be associated with increased risk of clear cell renal cancer. The aim of this study was to evaluate the association between CHEK2 mutation and RCC in our centre. Methods: We reviewed the medical records of 43 clear cell renal cancer patients (pts) who were diagnosed and treated in COI in Gliwice. Mutation profile was assessed by RFLP-PCR technique. In Poland, there are three polymorphic variants of CHEK2 1100delC, IVS2+1G →A (premature protein truncation), and a common missense variant (I157T) (substitution of an isoleucine for a threonine). We evaluated the presence of CHEK2 mutation in clear cell carcinoma. Results: In our study CHEK2 mutation (variant I157T) was detected in 7% pts. The median age of pts was 57 years (range from 34 to 74). Most of the patients were women (87%). All CHEK2 mutation carriers were women and were >65 years old. Cancer in family history were reported in 80% pts. Most frequently were: breast cancer (33%), gynecological cancers (33%), gastrointestinal cancers (27%), and renal cell carcinoma (20%). There was also described lung cancer in family history (7%). The most frequent cancers in family history in CHEK2 mutation carriers were: breast cancer and gynecological cancers. 20% of pts had other cancers in their history (breast cancer, ovarian cancer, and contralateral renal cell carcinoma). Contralateral renal cell carcinoma was reported in CHEK2 mutation carrier. All pts had nephrectomy due to RCC and all had clear cell renal cancer in histopathologic examination. All CHEK2 mutation carriers had higher grade (grade 3) and capsular invasion. 5% of CHEK2 mutation carriers had TP53 (c.[215G>C])polymorphism. Conclusions: Variant I157T of CHEK2 gene were found to be associated with increased risk of cancer in family history (breast cancer, gynecological cancer), and renal cancer of contralateral kidney. Factors associated with CHEK2 mutation carriers were higher histologic grade (G3) and elderly age.

Download Full-text

Intramammary Metastasis in a Patient with a History of Renal Cell Carcinoma: A Case Report

Case Reports in Oncology ◽

10.1159/000489391 ◽

2018 ◽

Vol 11 (2) ◽

pp. 318-322

Author(s):

Miyuki Kitahara ◽

Yasuo Hozumi ◽

Rio Asada ◽

Aya Sawa ◽

Hitoaki Saito ◽

...

Keyword(s):

Breast Cancer ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Needle Biopsy ◽

Malignant Tumors ◽

Definitive Diagnosis ◽

Benign Tumors ◽

Immunohistochemical Examination ◽

History Of

Intramammary metastasis of renal cell carcinoma (RCC) is extremely rare, accounting for only 1.5% of all intramammary metastases. Distinguishing intramammary metastases from benign tumors and breast cancer is clinically problematic. Some patients undergo excessive surgery after a misdiagnosis of breast cancer instead of a mammary tumor. We performed a core needle biopsy (CNB) of a breast mass that developed in a 71-year-old woman after surgeries for bilateral RCC and breast cancer, leading to a diagnosis of intramammary metastasis of RCC. In this case, the CNB and immunohistochemical examination were critical for reaching a definitive diagnosis. We conclude that, when examining patients with mammary tumors, establishing their history of malignant tumors may help diagnose intramammary metastasis and select the best treatment strategy.

Download Full-text

Metastatic renal cell carcinoma presenting as a breast mass in a woman with history of primary breast cancer

Journal of the Belgian Society of Radiology ◽

10.5334/jbr-btr.699 ◽

2011 ◽

Vol 94 (6) ◽

pp. 330

Author(s):

C Balliauw ◽

B Termote ◽

A Van Steen ◽

P Moerman ◽

M R Christiaens ◽

...

Keyword(s):

Breast Cancer ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Primary Breast Cancer ◽

Breast Mass ◽

History Of

Download Full-text

Genetic Predisposition to Renal Cell Carcinoma: Implications for Counseling, Testing, Screening, and Management

Journal of Clinical Oncology ◽

10.1200/jco.2018.79.2523 ◽

2018 ◽

Vol 36 (36) ◽

pp. 3560-3566 ◽

Cited By ~ 6

Author(s):

Brian Shuch ◽

Jin Zhang

Keyword(s):

Renal Cell Carcinoma ◽

Family History ◽

Cell Carcinoma ◽

Renal Cell ◽

Malignant Tumors ◽

Disease Onset ◽

Multidisciplinary Care ◽

Entire Family ◽

Her Family ◽

History Of

In many individuals with renal cell carcinoma (RCC), a hereditary cause may have contributed to cancer development. Various risk factors can be suggestive of a genetic contribution, including early disease onset, multifocal or bilateral tumors, family history of RCC, and personal/family history of other benign or malignant tumors. Genetic counseling and understanding of the entire family tree are the first steps in evaluation and will determine if the patient should proceed with testing. Methods of testing have changed to next-generation sequencing, which allows multiple genes to be evaluated together. The results of testing have significant implications for the individual and his or her family members. Screening of the kidney and at-risk organs ensues, with most algorithms focused on early diagnosis and intervention to limit morbidity and mortality of disease manifestations. A comprehensive clinical program that can offer multidisciplinary care is useful for several complex cancer syndromes. Management of localized and advanced hereditary kidney cancers may differ from the sporadic forms of RCC. Knowledge of the genetics can have significant management implications and if necessary genetic evaluation can be expedited to allow treatment decisions.

Download Full-text

Patients with intraductal papillary mucionous neoplasms of pancreas (IPMNs) are at increased risk of renal cell carcinoma, prostate, colorectal and breast cancer: a single center Italian experience

10.26226/morressier.59a6b342d462b80290b53fa8 ◽

2017 ◽

Author(s):

Nikola Panic

Keyword(s):

Breast Cancer ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Single Center ◽

Italian Experience ◽

Carcinoma Prostate ◽

Increased Risk

Download Full-text

Intradural Spinal Metastasis from Renal Cell Carcinoma: A Case Report

Journal of Orthopaedic Surgery ◽

10.1177/230949900100900212 ◽

2001 ◽

Vol 9 (2) ◽

pp. 57-61 ◽

Cited By ~ 17

Author(s):

Kan-Hing Mak ◽

John Ching-Kwong Kwok

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Spinal Metastasis ◽

Cauda Equina ◽

History Of ◽

Epidural Metastasis ◽

Cauda Equina Lesion ◽

Osseous Structure ◽

Intradural Space

Intradural spinal metastasis is rare. This is the third case ever reported on the finding of intradural spinal metastasis from a renal cell carcinoma that had been removed surgically. The patient had a history of epidural metastasis for which excision and anterior stabilization were done 3 years before the new presentation with cauda equina lesion. Seeding from the involved osseous structure to the cerebrospinal fluid through the dura was believed to be the course that tumour had taken to reach the intradural space.

Download Full-text

Synergistic Activity of Paclitaxel, Sorafenib, and Radiation Therapy in advanced Renal Cell Carcinoma and Breast Cancer

Translational Oncology ◽

10.1016/j.tranon.2018.11.007 ◽

2019 ◽

Vol 12 (2) ◽

pp. 381-388 ◽

Cited By ~ 3

Author(s):

Kyung Hwa Choi ◽

Jeong Yong Jeon ◽

Young-Eun Lee ◽

Seung Won Kim ◽

Sang Yong Kim ◽

...

Keyword(s):

Breast Cancer ◽

Renal Cell Carcinoma ◽

Radiation Therapy ◽

Cell Carcinoma ◽

Renal Cell ◽

Advanced Renal Cell Carcinoma ◽

Synergistic Activity

Download Full-text

Thyroid Metastasis of Renal Cell Carcinoma

World Journal of Endocrine Surgery ◽

10.5005/jp-journals-10002-1066 ◽

2011 ◽

Vol 3 (2) ◽

pp. 93-95 ◽

Cited By ~ 1

Author(s):

Bulent Citgez ◽

Mehmet Uludag ◽

Gurkan Yetkin ◽

Esin Kabul Gurbulak ◽

Banu Yılmaz Ozguven ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Thyroid Gland ◽

Cell Carcinoma ◽

Renal Cell ◽

Previous History ◽

Metastatic Tumor ◽

Thyroid Metastasis ◽

Thyroid Mass ◽

History Of ◽

Recurrent Malignancy

ABSTRACT Metastases to the thyroid gland are rare. We report the case of a 50-year-old man with an isolated thyroid metastasis from renal cell carcinoma (RCC), 3 years after radical nephrectomy for the primary disease. Although uncommon, if a patient with a previous history of malignancy has a new thyroid mass, it should be considered metastatic tumor of recurrent malignancy until proved otherwise.

Download Full-text