Intramammary Metastasis in a Patient with a History of Renal Cell Carcinoma: A Case Report

Intramammary metastasis of renal cell carcinoma (RCC) is extremely rare, accounting for only 1.5% of all intramammary metastases. Distinguishing intramammary metastases from benign tumors and breast cancer is clinically problematic. Some patients undergo excessive surgery after a misdiagnosis of breast cancer instead of a mammary tumor. We performed a core needle biopsy (CNB) of a breast mass that developed in a 71-year-old woman after surgeries for bilateral RCC and breast cancer, leading to a diagnosis of intramammary metastasis of RCC. In this case, the CNB and immunohistochemical examination were critical for reaching a definitive diagnosis. We conclude that, when examining patients with mammary tumors, establishing their history of malignant tumors may help diagnose intramammary metastasis and select the best treatment strategy.

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Incidence of benign versus malignant renal tumors in selected studies.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.5_suppl.357 ◽

2012 ◽

Vol 30 (5_suppl) ◽

pp. 357-357 ◽

Cited By ~ 2

Author(s):

Paul Russo ◽

Robert G. Uzzo ◽

William Thomas Lowrance ◽

Aviva Asnis-Alibozek ◽

Norman David LaFrance ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Malignant Tumors ◽

Early Stage ◽

Renal Tumors ◽

Benign Tumors ◽

Stage Migration ◽

Renal Masses ◽

Definitive Method

357 Background: Use of cross-sectional imaging has increased the detection rate for small renal tumors; more patients now present with early-stage renal cell carcinoma (RCC) or benign or indolent renal masses. Histopathology after surgical resection is the definitive method for characterizing renal tumors. Stage migration of renal masses creates uncertainty about the percentage of resected masses that will be benign vs malignant. We sought to better define these proportions through a targeted review of the literature. Methods: PubMed/select congresses were searched to identify the histologic classification of renal masses in a representative sample from the contemporary literature: [search] incidence AND (renal cell carcinoma AND benign); incidence AND (renal tumor AND benign); percentage AND (renal cell carcinoma AND benign); limit: 2003–2011. Results: Most representative studies included procedures conducted in the mid-1990s to the mid-to-late 2000s. Studies origin was US (n=8), Korea (n=3), China, Japan, Germany, Austria, Australia, and multisite (Israel/France/US; all n=1). Only 8 studies had n≥500 (range, 70–10,404). The proportion of benign masses are shown (see Table); half of the studies reported values between 16% and 17%. The majority found that benign tumors were more likely to be smaller in size (<4 or <7 cm) than malignant tumors. 11 studies reported the RCC subtype (% clear cell range, 46%–83%). Conclusions: Benign renal tumors occur ~15% of the time and are more prevalent among small masses. Nearly 25% of resected lesions are benign or indolent and may not require surgery. Preoperative discrimination of more aggressive renal masses would be an important clinical advance that could improve clinicians’ diagnostic confidence and guide patient management. Funding: Wilex AG/IBA Molecular. [Table: see text]

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HISTOPATHOLOGICAL SPECTRUM OF NEOPLASTIC LESIONS OF KIDNEY- A THREE YEARS STUDY

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i6.1956 ◽

2021 ◽

Vol 5 (6) ◽

Author(s):

Saket Sarswat ◽

Vimlesh . ◽

D.P. Soni

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Wilms Tumor ◽

Malignant Tumors ◽

Pathological Process ◽

Benign Tumors ◽

Older Individuals ◽

Neoplastic Lesions ◽

Paediatric Age

Background: Kidney can be involved in various pathological process. Both benign & malignant tumors can occur in the kidney. They arise from different components of renal parenchyma, notably tubular epithelium.1 99 percent of renal neoplasms are malignant, with renal cell carcinoma and wilm’s tumor being the most common2. Men have higher incidence than women (approximately 1.6:1) and vast majority are diagnosed after 65 years of age. Material and methods: Prospective and retrospective study from January 2017 to December 2019 in the Department of Pathology. Results: The study comprised of 67 cases of neoplastic conditions, out of which 63 cases are malignant and only 4 cases were recorded as benign. Conclusion: Malignant tumors far more common than benign lesions. In adults and older individuals, renal cell carcinoma was most common while among paediatric age group, wilms tumor was most common. Benign tumors were uncommon. Keywords: Kidney, renal cell carcinoma, wilms tumor

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Spontaneous Rupture of Renal Cell Carcinoma: A Rare Case Report

Clinical Oncology and Research ◽

10.31487/j.cor.2020.08.06 ◽

2020 ◽

pp. 1-3

Author(s):

Richa Chauhan ◽

Gyanendra Singh ◽

Upendra Prasad Singh

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Malignant Tumor ◽

Renal Cell ◽

Spontaneous Rupture ◽

Renal Mass ◽

Malignant Tumors ◽

Imaging Modality ◽

Benign Tumors ◽

Contrast Enhanced Ct

Renal cell carcinoma (RCC) is an uncommon malignant tumor of the kidney, particularly in the Asian population. It is more commonly seen in an elderly male patient with typical complains of haematuria, flank pain and lump. Recently incidental diagnosis of small RCCs has been rising due to increased used of abdominal imaging for other reasons. Spontaneous rupture of a renal mass leading to large perinephric collection and presenting as an acute pain abdomen in an adult male is a rare finding but should be considered as a differential diagnosis. The most common cause of spontaneously ruptured renal mass includes benign tumor as angiomyolipoma followed by malignant tumor like RCC, vascular causes, coagulation defects and infection in other cases. Contrast enhanced CT scan is the most common imaging modality used for diagnosis. Initial resuscitation depending up on the patient’s general condition followed by nephrectomy for malignant tumors and embolization for benign tumors is the treatment of choice.

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Studying the Association Between Breast Cancer and Renal Cell Carcinoma

10.21203/rs.3.rs-841536/v1 ◽

2021 ◽

Author(s):

Khalid A Jazieh ◽

Firas Baidoun ◽

Nataly Torrejon ◽

Zahi Merjaneh ◽

Anas Saad ◽

...

Keyword(s):

Breast Cancer ◽

Renal Cell Carcinoma ◽

Genetic Testing ◽

Family History ◽

Cell Carcinoma ◽

Renal Cell ◽

Case Reports ◽

Population Data ◽

Seer Database ◽

History Of

Abstract Purpose: There are case reports of patients with both primary breast cancer (BC) and renal cell carcinoma (RCC). We explore the association between these two malignancies using SEER population data and our institutional records.Methods: We studied the association between BC and RCC in the 2000-2016 Surveillance, Epidemiology and End Results (SEER) database. We then reviewed our hospital records of patients with both BC and RCC and collected information including personal and family history of cancers, genetic testing, and patient outcomes.Results: Of the 813,477 females diagnosed with BC in the SEER database, 1,914 later developed RCC. The risk of developing RCC was significantly increased within the first six months, 7-12 months, and 1-5 years following BC diagnosis with standardized incidence ratios (SIRs) of 5.08 (95% CI, 4.62- 5.57), 2.09 (95% CI, 1.8-2.42), and 1.15 (95% CI, 1.06-1.24), respectively. Of 56,200 females with RCC, 1,087 later developed BC. The risk of developing BC following RCC was elevated within the first six months (SIR of 1.45 [95% CI, 1.20-1.73]). For our hospital patients, 437 had both BC and RCC. 427 (97.71%) were female, and 358 (81.92%) were white, and breast cancer was diagnosed before RCC in 246 (61.5%) patients. There were 15 germline mutations in those with genetic testing. Conclusion:Our findings suggest that BC patients are at higher risk of developing RCC and vice versa. BC tended to precede RCC, and patients frequently had personal histories of other malignancies and a family history of cancer, particularly BC.

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Metastatic renal cell carcinoma presenting as a breast mass in a woman with history of primary breast cancer

Journal of the Belgian Society of Radiology ◽

10.5334/jbr-btr.699 ◽

2011 ◽

Vol 94 (6) ◽

pp. 330

Author(s):

C Balliauw ◽

B Termote ◽

A Van Steen ◽

P Moerman ◽

M R Christiaens ◽

...

Keyword(s):

Breast Cancer ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Primary Breast Cancer ◽

Breast Mass ◽

History Of

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Genetic Predisposition to Renal Cell Carcinoma: Implications for Counseling, Testing, Screening, and Management

Journal of Clinical Oncology ◽

10.1200/jco.2018.79.2523 ◽

2018 ◽

Vol 36 (36) ◽

pp. 3560-3566 ◽

Cited By ~ 6

Author(s):

Brian Shuch ◽

Jin Zhang

Keyword(s):

Renal Cell Carcinoma ◽

Family History ◽

Cell Carcinoma ◽

Renal Cell ◽

Malignant Tumors ◽

Disease Onset ◽

Multidisciplinary Care ◽

Entire Family ◽

Her Family ◽

History Of

In many individuals with renal cell carcinoma (RCC), a hereditary cause may have contributed to cancer development. Various risk factors can be suggestive of a genetic contribution, including early disease onset, multifocal or bilateral tumors, family history of RCC, and personal/family history of other benign or malignant tumors. Genetic counseling and understanding of the entire family tree are the first steps in evaluation and will determine if the patient should proceed with testing. Methods of testing have changed to next-generation sequencing, which allows multiple genes to be evaluated together. The results of testing have significant implications for the individual and his or her family members. Screening of the kidney and at-risk organs ensues, with most algorithms focused on early diagnosis and intervention to limit morbidity and mortality of disease manifestations. A comprehensive clinical program that can offer multidisciplinary care is useful for several complex cancer syndromes. Management of localized and advanced hereditary kidney cancers may differ from the sporadic forms of RCC. Knowledge of the genetics can have significant management implications and if necessary genetic evaluation can be expedited to allow treatment decisions.

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Rare localization of renal cell carcinoma metastases in the paranasal sinuses and breast: a case report

Medical Visualization ◽

10.24835/1607-0763-2018-6-13-22 ◽

2019 ◽

Vol 22 (6) ◽

pp. 13-22

Author(s):

E. V. Kryaneva ◽

N. A. Rubtsova ◽

A. V. Levshakova ◽

A. I. Khalimon ◽

A. V. Leontyev ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Paranasal Sinuses ◽

Renal Cell ◽

Clinical Case ◽

Clear Cell ◽

Malignant Tumors ◽

Metastatic Potential ◽

Cell Renal Cell Carcinoma ◽

Metastatic Lesions

This article presents a clinical case demonsratinga high metastatic potential of clear cell renal cell carcinoma combined with atypical metastases to breast and paranasal sinuses. The prevalence of metastatic lesions to the breast and paranasal sinuses in various malignant tumors depending on their morphological forms is analyzed. The authors present an analysis of data published for the last 30 years. The optimal diagnostic algorithms to detect the progression of renal cell carcinoma and to evaluate the effectiveness of the treatment are considered.

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Patients with intraductal papillary mucionous neoplasms of pancreas (IPMNs) are at increased risk of renal cell carcinoma, prostate, colorectal and breast cancer: a single center Italian experience

10.26226/morressier.59a6b342d462b80290b53fa8 ◽

2017 ◽

Author(s):

Nikola Panic

Keyword(s):

Breast Cancer ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Single Center ◽

Italian Experience ◽

Carcinoma Prostate ◽

Increased Risk

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Intradural Spinal Metastasis from Renal Cell Carcinoma: A Case Report

Journal of Orthopaedic Surgery ◽

10.1177/230949900100900212 ◽

2001 ◽

Vol 9 (2) ◽

pp. 57-61 ◽

Cited By ~ 17

Author(s):

Kan-Hing Mak ◽

John Ching-Kwong Kwok

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Spinal Metastasis ◽

Cauda Equina ◽

History Of ◽

Epidural Metastasis ◽

Cauda Equina Lesion ◽

Osseous Structure ◽

Intradural Space

Intradural spinal metastasis is rare. This is the third case ever reported on the finding of intradural spinal metastasis from a renal cell carcinoma that had been removed surgically. The patient had a history of epidural metastasis for which excision and anterior stabilization were done 3 years before the new presentation with cauda equina lesion. Seeding from the involved osseous structure to the cerebrospinal fluid through the dura was believed to be the course that tumour had taken to reach the intradural space.

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