scholarly journals A Capra Hircus Chromosome 19 Locus Linked to Milk Production Influences Mammary Conformation

Author(s):  
Andrew Jiang ◽  
Alex Ankersmit-Udy ◽  
Sally-Anne Turner ◽  
Megan Scholtens ◽  
Mathew D Littlejohn ◽  
...  

Abstract Background: Economically important milk production traits including milk volume, milk fat and protein yield vary considerably across dairy goats in New Zealand. A significant portion of the variation is attributable to genetic variation. Discovery of genetic markers linked to milk production traits can be utilised to drive selection of high-performance animals.A previously reported genome wide association study across dairy goats in New Zealand identified a quantitative trait loci (QTL) located on chromosome 19. The most significantly associated single nucleotide polymorphism (SNP) marker for this locus is located at position 26,610,610 (SNP marker 19:26,610,610). This locus is associated with multiple milk production traits including fat, protein and volume. The predicted effect of selection for the beneficial haplotype would result in an average production increase of 2.2kg fat, 1.9kg protein and 73.6kg volume.An outstanding question was whether selection for the beneficial allele would co-select for any negative pleiotropic effects. An adverse relationship between milk production and udder health traits has been reported at this locus. Therefore, a genome wide association study was undertaken looking for loci associated with udder traitsResults: The QTL and production associated marker 19:26,610,610 was identified in this study to also be associated with several goat udder traits including udder depth (UD), fore udder attachment (FUA) and rear udder attachment (RUA). Our study replicates the negative relationship between production and udder traits with the high production allele at position 19:26,610,610 associated with an adverse change in UD, FUA and RUAConclusions: Our study has confirmed this negative relationship between udder traits and production traits in the NZ goat population. We have found that the frequency of the high production allele is relatively high in the NZ goat population, indicating that its effect on udder conformation is not significantly detrimental on animal health. It will however be important to monitor udder conformation as the Chromosome 19 locus is progressively implemented for marker assisted selection. It will also be of interest to determine if the gene underlying the production QTL has a direct effect on mammary gland morphology or whether the changes observed are a consequence of the increased milk volume.

2019 ◽  
Vol 102 (6) ◽  
pp. 5305-5314 ◽  
Author(s):  
L.H.S. Iung ◽  
J. Petrini ◽  
J. Ramírez-Díaz ◽  
M. Salvian ◽  
G.A. Rovadoscki ◽  
...  

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0215204 ◽  
Author(s):  
Rosalia Di Gerlando ◽  
Anna Maria Sutera ◽  
Salvatore Mastrangelo ◽  
Marco Tolone ◽  
Baldassare Portolano ◽  
...  

2021 ◽  
Vol 20 (1) ◽  
pp. 1500-1505
Author(s):  
Anna Maria Sutera ◽  
Rosalia Di Gerlando ◽  
Salvatore Mastrangelo ◽  
Maria Teresa Sardina ◽  
Enrico D’Alessandro ◽  
...  

2020 ◽  
pp. 1-8
Author(s):  
Hamdy Abdel-Shafy ◽  
Mohamed A. A. Awad ◽  
Hussein El-Regalaty ◽  
S. E.-D. El-Assal ◽  
Samy Abou-Bakr

Abstract The objectives of the current study were to detect putative genomic loci and to identify candidate genes associated with milk production traits in Egyptian buffalo. A total number of 161 479 daily milk yield (DMY) records and 60 318 monthly measures for fat and protein percentages (FP and PP, respectively), along with fat and protein yields (FY and PY, respectively) from 1670 animals were used. Genotyping was performed using Axiom® Buffalo Genotyping 90 K array. Genome-wide association study (GWAS) for each trait was performed using PLINK. After Bonferroni correction, 47 SNPs were associated with one or more milk production traits. These SNPs were distributed over 36 quantitative trait loci (QTL) and located on 20 buffalo chromosomes (BBU). For the 47 SNPs, one was overlapped for three traits (DMY, FY, and PY), six were associated with two traits (one for PP and PY and five for FY and PY) while the rest were associated with only one trait. Out of 36 identified QTL, eleven were overlapped with previously reported loci in buffalo and/or cattle populations. Some of these SNPs are placed within or close to potential candidate genes, for example: TPD52, ZBTB10, RALYL and SNX16 on BBU15, ADGRD1 on BBU17, ESRRG on BBU5 and GRIP1 on BBU4. This is the first reported study between genome-wide markers and milk components in Egyptian buffalo. Our findings provide useful information to explore the genetic mechanisms and relevant genes contributing to the variation in milk production traits. Further confirmation studies with larger population size are necessary to validate the findings and detect the causal genetic variants.


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