scholarly journals Beta-Adrenergic Receptor Blockers and Hepatocellular Carcinoma Survival. A Systemic Review and Meta-Analysis

2021 ◽  
Author(s):  
Hyun Chang ◽  
Sung Hyun Lee
Keyword(s):  
Hepatocellular Carcinoma ◽  
Random Effects ◽  
Beta Blocker ◽  
Adrenergic Receptor ◽  
Meta Analysis ◽  
Systemic Review ◽  
Cochrane Library ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic ◽  
Receptor Blockers

Abstract IntroductionPre-clinical data has revealed that beta-adrenergic stimulation can affect the growth and progression of different types of malignancies. Beta-adrenergic receptor blockers have been associated with improved survival in patients with many types of cancer. We performed a meta-analysis to investigate the association between beta-blocker use and hepatocellular carcinoma (HCC) prognosis.MethodsIn this meta-analysis, a full search was conducted using PubMed, the Cochrane library, and Embase to identify all relevant studies published up to May 2021. Available hazard ratios (HRs) were extracted for overall survival (OS), cancer-specific survival (CSS) and pooled using a random effects meta-analysis.ResultsFour studies involving 7252 patients with HCC met the inclusion criteria and were included in the systemic review. Three studies that reported OS data of 5148 patients were included in the meta-analysis. The random-effects model showed that beta-blocker use was associated with significantly improved OS in HCC (HR = 0.69, 95% CI = 0.54-0.88, P = 0.0031), without significant heterogeneity (I2 = 41%; Q = 6.42, P = 0.18)ConclusionThis meta-analysis suggested that beta-blocker use can be associated with prolonged OS of patients with HCC.

scholarly journals Beta-adrenergic receptor blockers and liver cancer mortality in a national cohort of hepatocellular carcinoma patients

2020 ◽  
Vol 55 (5) ◽  
pp. 597-605
Author(s):  
Ruzan Udumyan ◽  
Scott Montgomery ◽  
Ann-Sofi Duberg ◽  
Fang Fang ◽  
Unnur Valdimarsdottir ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cancer Mortality ◽  
Adrenergic Receptor ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic ◽  
National Cohort ◽  
Receptor Blockers

Impact of spontaneous hepatocellular carcinoma rupture on surgical outcome after liver resection: a systemic review and meta-analysis

2020 ◽  
Author(s):  
Wei Zhang ◽  
Zhi-Yong Huang ◽  
Chang Shu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Recurrence Rate ◽  
Surgical Outcome ◽  
Meta Analysis ◽  
Systemic Review ◽  
Cochrane Library ◽  
Tumor Rupture ◽  
Significant Difference ◽  
The Impact

Abstract Background Spontaneous tumor rupture is a rare but life-threatening complication of hepatocellular carcinoma (HCC). The impact of spontaneous ruptured HCC on long-term survival after liver resection (LR) remains unclear. Our aim was to compare the surgical outcome in patients who underwent LR with ruptured and non-ruptured HCC . Methods A comprehensive search using PubMed, Embase, Cochrane Library and Science Citation Index Expanded databases was performed. The primary outcomes were the hazard ratio (HR) for overall survival ( OS) and disease free survival (DFS). The secondary outcomes included morbidity, hospital mortality and recurrence rate . Results Ten retrospective studies including 3222 patients met the inclusion criteria. Pooled analysis revealed a significantly poorer OS and DFS for patients with ruptured HCC compared to patients with non-ruptured HCC (HR, 2.02; 95% CI, 1.61-2.54; P< 0.00001 and HR, 1.92; 95% CI, 1.56-2.35; P<0.00001, respectively). In the subgroup analysis, both the propensity score matching (PSM) and non-PSM studies demonstrated a significantly poorer OS in the ruptured HCC group (P=0.02 and P<0.00001, respectively). However, meta-analysis of two PSM studies showed that there was not significant difference in the DFS between the two groups (P=0.50). Patients in the ruptured HCC group had a higher mortality and recurrence rate than the non-ruptured HCC group, but the difference was not significant (P = 0.05 and P = 0.06, respectively) Conclusions Surgical outcomes of the patients with the ruptured or non-ruptured HCC undergoing LR were not only affected by tumor rupture itself, but also by the tumor characteristics and liver functional status. Therefore, classifying all ruptured but resectable HCC as T4 stage is unable to accurately represent their true prognosis.

Prevalent role of Akt and ERK activation in cardioprotective effect of Ca2+ channel- and beta-adrenergic receptor blockers

2008 ◽  
Vol 321 (1-2) ◽  
pp. 155-164 ◽  
Author(s):  
Krisztina Kovacs ◽  
Katalin Hanto ◽  
Zita Bognar ◽  
Antal Tapodi ◽  
Eszter Bognar ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Cardioprotective Effect ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic ◽  
Erk Activation ◽  
Receptor Blockers

scholarly journals Association between Beta Adrenergic Receptor Polymorphism and Ischemic Stroke: A Meta-Analysis

2015 ◽  
Vol 17 (2) ◽  
pp. 138 ◽  
Author(s):  
Amit Kumar ◽  
Manya Prasad ◽  
Pradeep Kumar ◽  
Arun Kumar Yadav ◽  
Awadh Kishor Pandit ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Adrenergic Receptor ◽  
Meta Analysis ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic ◽  
Receptor Polymorphism
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