scholarly journals Antibody escape and global spread of SARS-CoV-2 lineage A.27

2021 ◽  
Author(s):  
Tamara Kaleta ◽  
Lisa Kern ◽  
Samuel Hong ◽  
Martin Hölzer ◽  
Georg Kochs ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
West Germany ◽  
Amino Acid Substitutions ◽  
Spike Gene ◽  
Multiple Introductions ◽  
Therapeutic Monoclonal Antibody ◽  
Western Africa ◽  
South West ◽  
Mutational Pattern ◽  
Global Spread

Abstract In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeographic analyses of A.27 sequences obtained from national and international databases reveal a global spread of this lineage through multiple introductions from its inferred origin in Western Africa. Variant A.27 is characterized by a mutational pattern in the spike gene that includes the L18F, L452R and N501Y spike amino acid substitutions found in various variants of concern but lacks the globally dominant D614G. Neutralization assays demonstrated an escape of A.27 from convalescent and vaccine-elicited antibody-mediated immunity. Moreover, the therapeutic monoclonal antibody Bamlanivimab and partially the REGN-COV2 cocktail failed to block infection by A.27. Our data emphasize the need for continued global monitoring of novel lineages because of the independent evolution of new escape mutations.

In-situ U-Pb dating of Ries Crater lacustrine carbonates (Miocene, South-West Germany): Implications for continental carbonate chronostratigraphy

2021 ◽  
Vol 568 ◽  
pp. 117011
Author(s):  
Damaris Montano ◽  
Marta Gasparrini ◽  
Axel Gerdes ◽  
Giovanna Della Porta ◽  
Richard Albert
Keyword(s):  
West Germany ◽  
South West ◽  
Lacustrine Carbonates

SAT0455 Prevalence of behçet’s disease in south-west germany among the adult turkish and german population

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 626.2-626
Author(s):  
F. Riewerts ◽  
J.C. Henes ◽  
C. Deuter ◽  
H.-M. Lorenz ◽  
F. Mackensen ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
West Germany ◽  
German Population ◽  
Behcet's Disease ◽  
South West

scholarly journals Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab

2017 ◽  
Vol 9 (1) ◽  
pp. 135-139 ◽  
Author(s):  
Shuguang Tan ◽  
Kefang Liu ◽  
Yan Chai ◽  
Catherine W.-H. Zhang ◽  
Shan Gao ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Binding Characteristics ◽  
Therapeutic Monoclonal Antibody

Detection and identification of a serine to arginine sequence variant in a therapeutic monoclonal antibody

2011 ◽  
Vol 879 (27) ◽  
pp. 2877-2884 ◽  
Author(s):  
Diya Ren ◽  
Jian Zhang ◽  
Ross Pritchett ◽  
Hongbin Liu ◽  
Jennifer Kyauk ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Sequence Variant ◽  
Therapeutic Monoclonal Antibody ◽  
Detection And Identification

Relationship between organic micropollutants and hydro-sedimentary processes at a karst spring in south-west Germany

2015 ◽  
Vol 532 ◽  
pp. 360-367 ◽  
Author(s):  
Ferry Schiperski ◽  
Johannes Zirlewagen ◽  
Olaf Hillebrand ◽  
Karsten Nödler ◽  
Tobias Licha ◽  
...  
Keyword(s):  
West Germany ◽  
Karst Spring ◽  
Organic Micropollutants ◽  
Sedimentary Processes ◽  
South West

scholarly journals Secular changes of anthropometric measures for the past 30 years in South-West Germany

2009 ◽  
Vol 63 (12) ◽  
pp. 1440-1443 ◽  
Author(s):  
G Nagel ◽  
M Wabitsch ◽  
C Galm ◽  
S Berg ◽  
S Brandstetter ◽  
...  
Keyword(s):  
West Germany ◽  
Anthropometric Measures ◽  
Secular Changes ◽  
The Past ◽  
South West

scholarly journals Extreme runoff response to short-duration convective rainfall in South-West Germany

2011 ◽  
Vol 8 (6) ◽  
pp. 10739-10780
Author(s):  
V. Ruiz-Villanueva ◽  
M. Borga ◽  
D. Zoccatelli ◽  
L. Marchi ◽  
E. Gaume ◽  
...  
Keyword(s):  
High Resolution ◽  
Flash Flood ◽  
Rain Gauge ◽  
Hydrologic Model ◽  
West Germany ◽  
Structure Evolution ◽  
Model Parameters ◽  
Distributed Hydrological Model ◽  
Precipitation Frequency ◽  
South West

Abstract. The 2 June 2008 flood-producing storm on the Starzel river basin in South-West Germany is examined as a prototype for organized convective systems that dominate the upper tail of the precipitation frequency distribution and are likely responsible for the flash flood peaks in this region. The availability of high-resolution rainfall estimates from radar observations and a rain gauge network, together with indirect peak discharge estimates from a detailed post-event survey, provides the opportunity to study the hydrometeorological and hydrological mechanisms associated with this extreme storm and the ensuing flood. Radar-derived rainfall, streamgauge data and indirect estimates of peak discharges are used along with a distributed hydrologic model to reconstruct hydrographs at multiple locations. The influence of storm structure, evolution and motion on the modeled flood hydrograph is examined by using the "spatial moments of catchment rainfall" (Zoccatelli et al., 2011). It is shown that downbasin storm motion had a noticeable impact on flood peak magnitude. Small runoff ratios (less than 20%) characterized the runoff response. The flood response can be reasonably well reproduced with the distributed hydrological model, using high resolution rainfall observations and model parameters calibrated at a river section which includes most of the area impacted by the storm.

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