Activation of Estrogen Receptor-Beta-Dependent Transcription by Estrogen-Independent Pathways

2002 ◽  
Author(s):  
Carolyn L. Smith
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Beta ◽  
Receptor Beta

scholarly journals Natural Herbal Estrogen-Mimetics (Phytoestrogens) Promote the Differentiation of Fallopian Tube Epithelium into Multi-Ciliated Cells via Estrogen Receptor Beta

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 722
Author(s):  
Maobi Zhu ◽  
Sen Takeda ◽  
Tomohiko Iwano
Keyword(s):  
Estrogen Receptor ◽  
Cell Differentiation ◽  
Epithelial Cells ◽  
Fallopian Tube ◽  
Ciliated Cell ◽  
Estrogen Receptor Beta ◽  
Notch Pathway ◽  
Secretory Cells ◽  
Ciliated Cells ◽  
Receptor Beta

Phytoestrogens are herbal polyphenolic compounds that exert various estrogen-like effects in animals and can be taken in easily from a foodstuff in daily life. The fallopian tube lumen, where transportation of the oocyte occurs, is lined with secretory cells and multi-ciliated epithelial cells. Recently, we showed that estrogen induces multi-ciliogenesis in the porcine fallopian tube epithelial cells (FTECs) through the activation of the estrogen receptor beta (ERβ) pathway and simultaneous inhibition of the Notch pathway. Thus, ingested phytoestrogens may induce FTEC ciliogenesis and thereby affect the fecundity. To address this issue, we added isoflavones (genistein, daidzein, or glycitin) and coumestan (coumestrol) to primary culture FTECs under air–liquid interface conditions and assessed the effects of each compound. All phytoestrogens except glycitin induced multi-ciliated cell differentiation, which followed Notch signal downregulation. On the contrary, the differentiation of secretory cells decreased slightly. Furthermore, genistein and daidzein had a slight effect on the proportion of proliferating cells exhibited by Ki67 expression. Ciliated-cell differentiation is inhibited by the ERβ antagonist, PHTPP. Thus, this study suggests that phytoestrogens can improve the fallopian tube epithelial sheet homeostasis by facilitating the genesis of multi-ciliated cells and this effect depends on the ERβ-mediated pathway.

A methylation signature at the CpG island promoter of estrogen receptor beta (ER-β) in breasts of women may be an early footmark of lack of breastfeeding and nulliparity

2021 ◽  
Vol 218 ◽  
pp. 153328
Author(s):  
Abdolreza Daraei ◽  
Pantea Izadi ◽  
Ghasemali Khorasani ◽  
Nahid Nafissi ◽  
Mohammad Mehdi Naghizadeh ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cpg Island ◽  
Estrogen Receptor Beta ◽  
Receptor Beta

scholarly journals Estrogen Receptor beta in Health and Disease1

2005 ◽  
Vol 73 (5) ◽  
pp. 866-871 ◽  
Author(s):  
Otabek Imamov ◽  
Gil-Jin Shim ◽  
Margaret Warner ◽  
Jan-Åke Gustafsson
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Beta ◽  
Receptor Beta

Estrogen Receptor Beta Gene Polymorphism and Intraocular Pressure Elevation in Female Patients With Primary Open-Angle Glaucoma

2010 ◽  
Vol 149 (5) ◽  
pp. 826-830.e2 ◽  
Author(s):  
Fumihiko Mabuchi ◽  
Yoichi Sakurada ◽  
Kenji Kashiwagi ◽  
Zentaro Yamagata ◽  
Hiroyuki Iijima ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Intraocular Pressure ◽  
Gene Polymorphism ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Estrogen Receptor Beta ◽  
Open Angle ◽  
Intraocular Pressure Elevation ◽  
Beta Gene ◽  
Receptor Beta

Abstract 1701: Estrogen receptor beta agonists as anti-tumor and immune-modulatory agents in malignant glioma

2021 ◽  
Author(s):  
Jordan Fredriksen Isaacs ◽  
Divya Ravi ◽  
Carmen L. del Genio ◽  
Zachary A. Shalit ◽  
Glenn C. Micalizio ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Malignant Glioma ◽  
Estrogen Receptor Beta ◽  
Beta Agonists ◽  
Receptor Beta
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