Membrane Estrogen Receptor Alpha Targeting and Its Association With SHC in Regulating Breast Cancer Cell Proliferation

2003 ◽  
Author(s):  
Robert X-D. Song
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Estrogen Receptor Alpha ◽  
Cancer Cell Proliferation ◽  
Breast Cancer Cell Proliferation ◽  
Receptor Alpha

scholarly journals A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation

2019 ◽  
Vol 47 (18) ◽  
pp. 9557-9572 ◽  
Author(s):  
Gozde Korkmaz ◽  
Zohar Manber ◽  
Rui Lopes ◽  
Stefan Prekovic ◽  
Karianne Schuurman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Hormonal Treatment ◽  
Ctcf Binding ◽  
Chromatin Conformation ◽  
Cancer Cell Proliferation ◽  
Breast Cancer Cell Proliferation

Abstract Estrogen receptor α (ERα) is an enhancer activating transcription factor, a key driver of breast cancer and a main target for cancer therapy. ERα-mediated gene regulation requires proper chromatin-conformation to facilitate interactions between ERα-bound enhancers and their target promoters. A major determinant of chromatin structure is the CCCTC-binding factor (CTCF), that dimerizes and together with cohesin stabilizes chromatin loops and forms the boundaries of topologically associated domains. However, whether CTCF-binding elements (CBEs) are essential for ERα-driven cell proliferation is unknown. To address this question in a global manner, we implemented a CRISPR-based functional genetic screen targeting CBEs located in the vicinity of ERα-bound enhancers. We identified four functional CBEs and demonstrated the role of one of them in inducing chromatin conformation changes in favor of activation of PREX1, a key ERα target gene in breast cancer. Indeed, high PREX1 expression is a bona-fide marker of ERα-dependency in cell lines, and is associated with good outcome after anti-hormonal treatment. Altogether, our data show that distinct CTCF-mediated chromatin structures are required for ERα- driven breast cancer cell proliferation.

scholarly journals Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation

2013 ◽  
Vol 73 (19) ◽  
pp. 5936-5948 ◽  
Author(s):  
Filipa G. Pinho ◽  
Adam E. Frampton ◽  
Joao Nunes ◽  
Jonathan Krell ◽  
Heba Alshaker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Sphingosine Kinase ◽  
Cancer Cell Proliferation ◽  
Sphingosine Kinase 1 ◽  
Breast Cancer Cell Proliferation

scholarly journals SHARPIN stabilizes estrogen receptor α and promotes breast cancer cell proliferation

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 77137-77151 ◽  
Author(s):  
Ting Zhuang ◽  
Sifan Yu ◽  
Lichen Zhang ◽  
Huijie Yang ◽  
Xin Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Estrogen Receptor Α ◽  
Cancer Cell Proliferation ◽  
Breast Cancer Cell Proliferation
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