The Role of IQGAP1 in Neoplastic Growth and Metastasis

2004 ◽  
Author(s):  
Monideepa Roy ◽  
David Sacks
Keyword(s):  
Neoplastic Growth

The Role of IQGAP1 in Neoplastic Growth and Metastasis

2003 ◽  
Author(s):  
Monideepa Roy ◽  
David Sacks
Keyword(s):  
Neoplastic Growth

scholarly journals E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: role of Rho GTPases

Oncogene ◽  
2010 ◽  
Vol 29 (19) ◽  
pp. 2760-2771 ◽  
Author(s):  
L Asnaghi ◽  
W C Vass ◽  
R Quadri ◽  
P M Day ◽  
X Qian ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Rho Gtpases ◽  
Small Cell ◽  
Small Cell Lung ◽  
Neoplastic Growth ◽  
E Cadherin

An Essential Role of Th1 Responses and Interferon-gamma in Infection-Mediated Suppression of Neoplastic Growth

2003 ◽  
Vol 2 (6) ◽  
pp. 685-691 ◽  
Author(s):  
Erinn B. Rankin ◽  
Duonan Yu
Keyword(s):  
Interferon Gamma ◽  
Essential Role ◽  
Neoplastic Growth

scholarly journals Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila

Development ◽  
2022 ◽  
Author(s):  
Rémi Logeay ◽  
Charles Géminard ◽  
Patrice Lassus ◽  
Miriam Rodríguez-Vázquez ◽  
Diala Kantar ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Notch Pathway ◽  
Genetic Alterations ◽  
Wing Disc ◽  
Bzip Transcription Factor ◽  
Epithelial Polarity ◽  
Neoplastic Growth ◽  
Cell Architecture ◽  
Transcriptional Output

Aggressive neoplastic growth can be initiated by a limited number of genetic alterations, such as the well-established cooperation between loss of cell architecture and hyperactive signaling pathways. However, our understanding of how these different alterations interact and influence each other remains very incomplete. Using Drosophila paradigms of imaginal wing disc epithelial growth, we have monitored the changes in Notch pathway activity according to the polarity status of cells (scrib mutant). We show that the scrib mutation impacts the direct transcriptional output of the Notch pathway, without altering the global distribution of Su(H), the Notch dedicated transcription factor. The Notch-dependent neoplasms require however, the action of a group of transcription factors, similar to those previously identified for Ras/scrib neoplasm (namely AP-1, Stat92E, Ftz-F1, and bZIP factors), further suggesting the importance of this transcription factor network during neoplastic growth. Finally our work highlights some Notch/scrib specificities, in particular the role of the PAR domain containing bZIP transcription factor and Notch direct target Pdp1 for neoplastic growth.

The Role of IQGAP1 in Neoplastic Growth and Metastasis

2005 ◽  
Author(s):  
Monideepa Roy ◽  
David Sacks
Keyword(s):  
Neoplastic Growth

Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth

Nature ◽  
10.1038/31008 ◽  
1998 ◽  
Vol 393 (6684) ◽  
pp. 483-487 ◽  
Author(s):  
Nicole Schreiber-Agus ◽  
Yong Meng ◽  
Tin Hoang ◽  
Harry Hou ◽  
Ken Chen ◽  
...  
Keyword(s):  
Neoplastic Growth ◽  
Organ Systems

scholarly journals Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Stefania Staibano ◽  
Gennaro Ilardi ◽  
Vincenza Leone ◽  
Chiara Luise ◽  
Francesco Merolla ◽  
...  
Keyword(s):  
Germ Cell ◽  
Critical Role ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Neoplastic Growth

scholarly journals Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila

2020 ◽  
Author(s):  
Rémi Logeay ◽  
Charles Géminard ◽  
Patrice Lassus ◽  
Diala Kantar ◽  
Lisa Héron-Milhavet ◽  
...  
Keyword(s):  
Notch Pathway ◽  
Genetic Alterations ◽  
Wing Disc ◽  
Epithelial Polarity ◽  
Neoplastic Growth ◽  
Cell Architecture ◽  
Imaginal Wing Disc ◽  
Transcriptional Output ◽  
Epithelial Growth

SUMMARYAggressive neoplastic growth can be initiated by a limited number of genetic alterations, such as the well-established cooperation between loss of cell architecture and hyperactive signaling pathways. However, our understanding of how these different alterations interact and influence each other remains very incomplete. Using Drosophila paradigms of imaginal wing disc epithelial growth, we have monitored the changes in Notch pathway activity according to the polarity status of cells and show that epithelial polarity changes directly impact the transcriptional output of the Notch pathway. Importantly, we show that this Notch pathway redirection is not mediated by a redeployment of Su(H), the Notch dedicated transcription factor, but relies on the cooperation with a combination of oncogenic transcription factors. Our work highlights in particular the role of the stress response CEBPG homologue CG6272/Irbp18 and of its partner Xrp1 suggesting that parts of the cellular competition program might promote neoplastic growth.

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