Inhibition of Breast Cancer-Induced Angiogenesis by a Diverged Homeobox Gene

2005 ◽  
Author(s):  
David H. Gorski
Keyword(s):  
Breast Cancer ◽  
Homeobox Gene

Abstract 1409: The BP1 homeobox gene is dysregulated in triple negative breast cancer

2014 ◽  
Author(s):  
Saurabh Kirolikar ◽  
Mandeep Gill ◽  
Silma Pereira ◽  
Svetlana Ghinbouschi ◽  
Luciane Cavalli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Homeobox Gene

Abstract 3056: Amplification of the BP1 homeobox gene in familial breast cancer with BRCA1/2 mutations

2011 ◽  
Author(s):  
Silma R. Pereira ◽  
Marcia M.C. Oliveira ◽  
Bassem R. Haddad ◽  
Patricia E. Berg ◽  
Luciane R. Cavalli
Keyword(s):  
Breast Cancer ◽  
Familial Breast Cancer ◽  
Homeobox Gene

scholarly journals Examination ofPOU homeobox gene expression in human breast cancer cells

1999 ◽  
Vol 81 (1) ◽  
pp. 104-112 ◽  
Author(s):  
Tianru Jin ◽  
Donald R. Branch ◽  
Xiaoyun Zhang ◽  
Shangle Qi ◽  
Bruce Youngson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Homeobox Gene ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Correlation of expression of BP1, a homeobox gene, with estrogen receptor status in breast cancer

2003 ◽  
Vol 5 (4) ◽  
Author(s):  
Sidney W Fu ◽  
Arnold Schwartz ◽  
Holly Stevenson ◽  
Joseph J Pinzone ◽  
Gregory J Davenport ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptor Status ◽  
Homeobox Gene ◽  
Receptor Status

scholarly journals Loss of HOXB3 correlates with the development of hormone receptor negative breast cancer

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10421
Author(s):  
Lizhe Zhu ◽  
Shibo Yu ◽  
Siyuan Jiang ◽  
Guanqun Ge ◽  
Yu Yan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Western Blot ◽  
Poor Prognosis ◽  
Hormone Receptors ◽  
Homeobox Gene ◽  
Metastatic Breast ◽  
Normal Breast ◽  
Bioinformatics Analyses ◽  
Specific Nuclear Protein

Background The homeobox gene family, encoding a specific nuclear protein, is essential for embryonic development, differentiation, and homeostasis. The role of the HOXB3 protein varies in different tumors. This study aims to explore the role of the HOXB3 gene in breast cancer. Method Differentially expressed genes were screened by analyzing metastatic breast cancer gene chip data from TCGA and GEO databases. The function of the selected HOXB3 gene was also analyzed in different databases and through molecular biology methods, such as qRT-PCR, western blot and IF to verify bioinformatics findings. Results Both bioinformatics analyses and western blot showed that HOXB3 was lost in breast cancer compared to normal breast tissue. Survival analysis also showed that lower expression of HOXB3 was associated with poor prognosis. Bioinformatics analyses further showed that HOXB3 was positively correlated with hormone receptors. Metascape for GO analysis of GEO data provided possible mechanisms that HOXB3 could positively regulate cell adhesion, inhibit cell proliferation and activate immune response in breast cancer; moreover, GSEA included several cancer-associated pathways. Conclusion In summary, HOXB3 expression was decreased in breast cancer, and it was associated with poor prognosis. It might become a new biomarker to predict prognosis of breast cancer.

Inhibition of Breast Cancer-Induced Angiogenesis by a Diverged Homeobox Gene

2004 ◽  
Author(s):  
David H. Gorski
Keyword(s):  
Breast Cancer ◽  
Homeobox Gene

scholarly journals Amplification of the BP1 homeobox gene in breast cancer

2008 ◽  
Vol 187 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Luciane R. Cavalli ◽  
Yan-Gao Man ◽  
Arnold M. Schwartz ◽  
Janice D. Rone ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Homeobox Gene

Expression of BP1, a novel homeobox gene, correlates with breast cancer progression and invasion

2005 ◽  
Vol 90 (3) ◽  
pp. 241-247 ◽  
Author(s):  
Yan-gao Man ◽  
Sidney W. Fu ◽  
Arnold Schwartz ◽  
Joseph J. Pinzone ◽  
Samuel J. Simmens ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Homeobox Gene ◽  
Breast Cancer Progression

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Further Ultrastructural Observations on Metastatic Nodules of Human Breast Cancer

1968 ◽  
Vol 26 ◽  
pp. 224-225
Author(s):  
John L. Swedo ◽  
R. W. Talley ◽  
John H. L. Watson
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Estrogen Therapy ◽  
Specimen Preparation ◽  
Human Breast ◽  
Autophagic Vacuoles ◽  
Previous Communication ◽  
Linear Profiles ◽  
Metastatic Nodule

Since the report, which described the ultrastructure of a metastatic nodule of human breast cancer after estrogen therapy, additional ultrastructural observations, including some which are correlative with pertinent findings in the literature concerning mycoplasmas, have been recorded concerning the same subject. Specimen preparation was identical to that in.The mitochondria possessed few cristae, and were deteriorated and vacuolated. They often contained particulates and fibrous structures, sometimes arranged in spindle-shaped bundles, Fig. 1. Another apparent aberration was the occurrence, Fig. 2 (arrows) of linear profiles of what seems to be SER, which lie between layers of RER, and are often recognizably continuous with them.It was noted that the structure of the round bodies, interpreted as within autophagic vacuoles in the previous communication, and of vesicular bodies, described morphologically closely resembled those of some mycoplasmas. Specifically, they simulated or reflected the various stages of replication reported for mycoplasmas grown on solid nutrient. Based on this observation, they are referred to here as “mycoplasma-like” structures, in anticipation of confirmatory evidence from investigations now in progress.

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