The Role of a Mitochondrial Progesterone Receptor in the Growth of Breast Epithelial Cells

2009 ◽  
Author(s):  
Thomas M. Price
Keyword(s):  
Epithelial Cells ◽  
Progesterone Receptor ◽  
Breast Epithelial Cells ◽  
Breast Epithelial

Abstract 3172: ZEB1 regulation in breast epithelial cells: Role of IGF-1 in the CCN6 modulation pathway

2010 ◽  
Author(s):  
Guadalupe Lorenzatti ◽  
Anupama Pal ◽  
Wei Huang ◽  
Ana M. Cabanillas ◽  
Celina G. Kleer
Keyword(s):  
Epithelial Cells ◽  
Breast Epithelial Cells ◽  
Breast Epithelial

scholarly journals Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome.

1995 ◽  
Vol 15 (1) ◽  
pp. 425-432 ◽  
Author(s):  
J W Shay ◽  
G Tomlinson ◽  
M A Piatyszek ◽  
L S Gollahon
Keyword(s):  
Epithelial Cells ◽  
P53 Gene ◽  
Wild Type ◽  
Stromal Fibroblasts ◽  
Breast Epithelial Cells ◽  
Li Fraumeni Syndrome ◽  
Human Papillomavirus Type 16 ◽  
Breast Epithelial

Individuals with germ line mutations in the p53 gene, such as Li-Fraumeni syndrome (LFS), have an increased occurrence of many types of cancer, including an unusually high incidence of breast cancer. This report documents that normal breast epithelial cells obtained from a patient with LFS (with a mutation at codon 133 of the p53 gene) spontaneously immortalized in cell culture while the breast stromal fibroblasts from this same patient did not. Spontaneous immortalization of human cells in vitro is an extremely rare event. This is the first documented case of the spontaneous immortalization of breast epithelial cells from a patient with LFS in culture. LFS patient breast stromal fibroblasts infected with a retroviral vector containing human papillomavirus type 16 E7 alone were able to immortalize, whereas stromal cells obtained from patients with wild-type p53, similarly infected with human papillomavirus type 16 E7, did not. The present results indicate a protective role of normal pRb-like functions in breast stromal fibroblasts but not in breast epithelial cells and reinforces an important role of wild-type p53 in the regulation of the normal growth and development of breast epithelial tissue.

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