Notch in Pathological Angiogenesis and Lymphangiogenesis

2011 ◽  
Author(s):  
Minji Kim
Keyword(s):  
Pathological Angiogenesis

scholarly journals Future Perspectives of Therapeutic, Diagnostic and Prognostic Aptamers in Eye Pathological Angiogenesis

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1455
Author(s):  
Emilio Iturriaga-Goyon ◽  
Beatriz Buentello-Volante ◽  
Fátima Sofía Magaña-Guerrero ◽  
Yonathan Garfias
Keyword(s):  
Clinical Trials ◽  
Macular Degeneration ◽  
Small Molecules ◽  
Inflammatory Diseases ◽  
Age Related Macular Degeneration ◽  
Future Perspectives ◽  
Whole Cells ◽  
Pathological Angiogenesis ◽  
Age Related ◽  
Viral Particles

Aptamers are single-stranded DNA or RNA oligonucleotides that are currently used in clinical trials due to their selectivity and specificity to bind small molecules such as proteins, peptides, viral particles, vitamins, metal ions and even whole cells. Aptamers are highly specific to their targets, they are smaller than antibodies and fragment antibodies, they can be easily conjugated to multiple surfaces and ions and controllable post-production modifications can be performed. Aptamers have been therapeutically used for age-related macular degeneration, cancer, thrombosis and inflammatory diseases. The aim of this review is to highlight the therapeutic, diagnostic and prognostic possibilities associated with aptamers, focusing on eye pathological angiogenesis.

Ferrite-encapsulated nanoparticles with stable photothermal performance for multimodal imaging-guided atherosclerotic plaque neovascularization therapy

2021 ◽  
Author(s):  
Zhuowen Yang ◽  
Jianting Yao ◽  
Jianxin Wang ◽  
Cong Zhang ◽  
Yang Cao ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Multimodal Imaging ◽  
Plaque Rupture ◽  
Pathological Angiogenesis ◽  
Atherosclerotic Plaque Rupture ◽  
Encapsulated Nanoparticles

Pathological angiogenesis is a critical contributor to atherosclerotic plaque rupture. However, there are few effective theranostic strategies to stabilize plaques by suppressing neovascularization. A polymeric nanosystem using 3 nm manganese...

scholarly journals FKBPL Is a Critical Antiangiogenic Regulator of Developmental and Pathological Angiogenesis

2015 ◽  
Vol 35 (4) ◽  
pp. 845-854 ◽  
Author(s):  
Anita Yakkundi ◽  
Rachel Bennett ◽  
Ivette Hernández-Negrete ◽  
Jean-Marie Delalande ◽  
Mary Hanna ◽  
...  
Keyword(s):  
Pathological Angiogenesis

scholarly journals Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis

Development ◽  
2014 ◽  
Vol 141 (3) ◽  
pp. 556-562 ◽  
Author(s):  
A. Fantin ◽  
B. Herzog ◽  
M. Mahmoud ◽  
M. Yamaji ◽  
A. Plein ◽  
...  
Keyword(s):  
Pathological Angiogenesis ◽  
Neuropilin 1

scholarly journals TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types

Cancer Cell ◽  
2012 ◽  
Vol 21 (2) ◽  
pp. 212-226 ◽  
Author(s):  
Amit Chaudhary ◽  
Mary Beth Hilton ◽  
Steven Seaman ◽  
Diana C. Haines ◽  
Susan Stevenson ◽  
...  
Keyword(s):  
Multiple Cancer ◽  
Pathological Angiogenesis ◽  
Cancer Types

scholarly journals The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Anne Wolf ◽  
Marc Herb ◽  
Michael Schramm ◽  
Thomas Langmann
Keyword(s):  
Pathological Angiogenesis

scholarly journals PFKFB3: A Potential Key to Ocular Angiogenesis

2021 ◽  
Vol 9 ◽  
Author(s):  
Zi-Yi Zhou ◽  
Lin Wang ◽  
Yu-Sheng Wang ◽  
Guo-Rui Dou
Keyword(s):  
Cell Metabolism ◽  
Current Treatment ◽  
Potential Treatment ◽  
Ocular Angiogenesis ◽  
Pathological Angiogenesis ◽  
Novel Treatment ◽  
Promising Target ◽  
Long Time ◽  
New Evidence ◽  
Endothelial Cell Metabolism

The current treatment for ocular pathological angiogenesis mainly focuses on anti-VEGF signals. This treatment has been confirmed as effective despite the unfavorable side effects and unsatisfactory efficiency. Recently, endothelial cell metabolism, especially glycolysis, has been attracting attention as a potential treatment by an increasing number of researchers. Emerging evidence has shown that regulation of endothelial glycolysis can influence vessel sprouting. This new evidence has raised the potential for novel treatment targets that have been overlooked for a long time. In this review, we discuss the process of endothelial glycolysis as a promising target and consider regulation of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as treatment for ocular pathological angiogenesis.

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