scholarly journals Sperm motion analysis in rats treated with adriamycin and its applicability to male reproductive toxicity studies.

2001 ◽  
Vol 26 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Masashi KATO ◽  
Sachiko MAKINO ◽  
Hitoshi KIMURA ◽  
Takao OTA ◽  
Tadakazu FURUHASHI ◽  
...  
Keyword(s):  
Motion Analysis ◽  
Reproductive Toxicity ◽  
Toxicity Studies ◽  
Sperm Motion

scholarly journals IMPACT OF GLOBALIZATION UNDER THE ICH GUIDELINES ON THE CONDUCT OF REPRODUCTIVE TOXICITY STUDIES-REPORT ON CURRENT STATUS IN JAPAN, EUROPE AND THE US BY QUESTIONNAIRE SURVEY

2004 ◽  
Vol 29 (3) ◽  
pp. 201-215 ◽  
Author(s):  
Hiroshi MINESHIMA ◽  
Yoshihiko ENDO ◽  
Hiroyuki OGASAWARA ◽  
Keiji NISHIGAKI ◽  
Toshiaki NUMA ◽  
...  
Keyword(s):  
Questionnaire Survey ◽  
Reproductive Toxicity ◽  
Current Status ◽  
Toxicity Studies ◽  
Ich Guidelines ◽  
The Us

scholarly journals On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe

2011 ◽  
Vol 61 (2) ◽  
pp. 251-260 ◽  
Author(s):  
Emiel Rorije ◽  
André Muller ◽  
Manon E.W. Beekhuijzen ◽  
Ulla Hass ◽  
Barbara Heinrich-Hirsch ◽  
...  
Keyword(s):  
Second Generation ◽  
Reproductive Toxicity ◽  
Toxicity Studies ◽  
The Impact

A 90-day subchronic toxicity study and reproductive toxicity studies on ACE-inhibiting lactotripeptide

2007 ◽  
Vol 45 (8) ◽  
pp. 1468-1477 ◽  
Author(s):  
M.P. Dent ◽  
S. O’Hagan ◽  
W.H. Braun ◽  
P. Schaetti ◽  
A. Marburger ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Toxicity Study ◽  
Subchronic Toxicity ◽  
Toxicity Studies

Reproductive toxicity testing of pharmaceutical compounds to support the inclusion of women in clinical trials

1997 ◽  
Vol 16 (5) ◽  
pp. 239-246 ◽  
Author(s):  
Chris Parkinson ◽  
Kate E Thomas ◽  
Cyndy E Lumley
Keyword(s):  
Clinical Trials ◽  
Drug Development ◽  
Animal Studies ◽  
Clinical Investigation ◽  
Reproductive Toxicity ◽  
Toxicity Testing ◽  
Toxicity Tests ◽  
Toxicity Studies ◽  
Important Concern ◽  
The Usa

1 The potential for toxicity to reproduction and the developing fetus is an important concern requiring attention during the development of new medicines. However, there are differences in the opinions of the regulatory authorities in Europe, Japan and the USA regarding the nature and amount of data from reproductive toxicity tests that should be available at the various stages of clinical development. 2 Forty-one companies or their subsidiaries from Eur ope, Japan and the USA provided data for a ques tionnaire-based study, carried out in 1994, to ascertain the practices of pharmaceutical companies and their views on an ideal approach to the timing of reproduc tion and development toxicity studies in relation to clinical investigation. 3 Differences were identified in the stage of drug development at which animal studies were completed, the sequence of completion of specific studies, and the extent of reproduction testing completed to support the inclusion of women in clinical trials. 4 A harmonised, but flexible, guideline, encompassing the timing of reproductive toxicity studies in relation to clinical trials, would permit better integration between clinical and non-clinical studies in an international drug development programme.

Reproductive toxicity studies with oxybutynin hydrochloride

Toxicology ◽  
1986 ◽  
Vol 40 (1) ◽  
pp. 31-44 ◽  
Author(s):  
J.A. Edwards ◽  
Y.J. Reid ◽  
D.D. Cozens
Keyword(s):  
Reproductive Toxicity ◽  
Toxicity Studies ◽  
Oxybutynin Hydrochloride

scholarly journals Utilization of a Computer-Assisted Sperm Motion Analysis System to Examine Effects of Dinoseb on Rat Sperm.

2000 ◽  
Vol 46 (5) ◽  
pp. 279-286 ◽  
Author(s):  
Masako SATO ◽  
Ryo OHTA ◽  
Kazuyoshi WADA ◽  
Hideki MARUMO ◽  
Mariko SHIROTA ◽  
...  
Keyword(s):  
Motion Analysis ◽  
Computer Assisted ◽  
Motion Analysis System ◽  
Analysis System ◽  
Sperm Motion
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