Studies on the Metabolic Fate on Ultra Short Acting .BETA.1 Blocker ONO-1101. (2). Plasma Concentration-Time Profile, Distribution, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Intravenous Administration to Rats.

Ken TSUNEKAWA; Haruo IMAWAKA; Kiyoshi NATSUI; Hiroaki FUJIMOTO; Masatsune ISHIDO; Kimio SHIBAKAWA; Seiji HIRAKU

doi:10.2133/dmpk.12.22

Studies on the Metabolic Fate on Ultra Short Acting .BETA.1 Blocker ONO-1101. (2). Plasma Concentration-Time Profile, Distribution, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Intravenous Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.22 ◽

1997 ◽

Vol 12 (1) ◽

pp. 22-30

Author(s):

Ken TSUNEKAWA ◽

Haruo IMAWAKA ◽

Kiyoshi NATSUI ◽

Hiroaki FUJIMOTO ◽

Masatsune ISHIDO ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Enzyme Activities ◽

Time Profile ◽

Metabolic Fate ◽

Short Acting ◽

Concentration Time ◽

Drug Metabolizing Enzyme ◽

Profile Distribution ◽

Metabolizing Enzyme

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Studies on the Metabolic Fate of Ultra Short Acting .BETA.1 Blocker ONO-1101. (1). Plasma Concentration-time Profile, Distribution and Excretion after Single Intravenous Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.5 ◽

1997 ◽

Vol 12 (1) ◽

pp. 5-21 ◽

Cited By ~ 1

Author(s):

Ken TSUNEKAWA ◽

Haruo IMAWAKA ◽

Hiroaki FUJIMOTO ◽

Masatsune ISHIDO ◽

Kimio SHIBAKAWA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Time Profile ◽

Metabolic Fate ◽

Short Acting ◽

Concentration Time ◽

Profile Distribution ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of Ultra Short Acting .BETA.1 Blocker ONO-1101. (4). Plasma Concentration-Time Profile after Single Intravenous Administration or Infusion to Beagle Dogs and Effects of Anesthetic.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.42 ◽

1997 ◽

Vol 12 (1) ◽

pp. 42-47

Author(s):

Ken TSUNEKAWA ◽

Kimiko SAKAGUCHI ◽

Kiyoshi NATSUI ◽

Yasuhiro NAKAO ◽

Kimio SHIBAKAWA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Time Profile ◽

Beagle Dogs ◽

Metabolic Fate ◽

Short Acting ◽

Concentration Time ◽

Single Intravenous Administration

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Studies on the disposion of (14C)NB-506: Plasma Concentration-Time Profile, Distribution, Metabolism and Excretion of (14C)NB-506 after Single and Repeated Intravenous Administration in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.337 ◽

1998 ◽

Vol 13 (4) ◽

pp. 337-345

Author(s):

Mikio ISHII ◽

Norihiro TAKENAGA ◽

Hiroyuki ISHIZAKI ◽

Toshio KAMEI ◽

Shin-ichi NINOMIYA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Time Profile ◽

Concentration Time ◽

Profile Distribution

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Metabolic Fate of Lactitol (NS-4). (II). Distribution, Transfer to Fetus and Milk after Single Administration and Metabolic Fate, Effect on the Hepatic Drug-Metabolizing Enzyme Activities after Repeated Administration in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.90 ◽

1995 ◽

Vol 10 (1) ◽

pp. 90-118

Author(s):

Tomoo TSUJIOKA ◽

Masayuki AGOU ◽

Hideya MUKAI ◽

Akira MORINO ◽

Yoshio ESUMI ◽

...

Keyword(s):

Enzyme Activities ◽

Repeated Administration ◽

Single Administration ◽

Metabolic Fate ◽

Hepatic Drug ◽

Drug Metabolizing Enzyme ◽

Metabolizing Enzyme

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Studies on the Metabolic Fate of Levothyroxine-Sodium. (1): Plasma Concentration of T4, T3 and TSH, Protein Binding and the Hepatic Drug-Metabolizing Enzyme Activity in Thyroidectomized Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.9.184 ◽

1994 ◽

Vol 9 (2) ◽

pp. 184-200

Author(s):

Satoshi IWAMURA ◽

Hiromi MORI ◽

Noriyuki KUWAYAMA ◽

Akira FUJIKATA

Keyword(s):

Enzyme Activity ◽

Plasma Concentration ◽

Protein Binding ◽

Levothyroxine Sodium ◽

Metabolic Fate ◽

Hepatic Drug ◽

Drug Metabolizing Enzyme ◽

Metabolizing Enzyme

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Studies on the metabolic fate of (.+-.)-1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-isopropylamino-2-propanol hydrochloride (betaxolol hydrochloride). (2): Blood level profiles, distribution, metabolism, excretion, aecumulation and effects on the hepatic drug-metabolizing enzyme activities of betaxolol after repeated oral administration to rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.5.699 ◽

1990 ◽

Vol 5 (5) ◽

pp. 699-710

Author(s):

Seiu IIDA ◽

Tomio INOKUCHI ◽

Masato IWAMOTO ◽

Yukimi YONEYAMA ◽

Jun TATSUNO ◽

...

Keyword(s):

Oral Administration ◽

Blood Level ◽

Enzyme Activities ◽

Metabolic Fate ◽

Hepatic Drug ◽

Drug Metabolizing Enzyme ◽

Metabolizing Enzyme

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Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na (2): Plasma concentration-profile, Distribusion and Excretion after Repeated Intravenous Bolus Administration to Rats and Effects on Metabolizing Enzyme Activities.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.566 ◽

1997 ◽

Vol 12 (6) ◽

pp. 566-575 ◽

Cited By ~ 1

Author(s):

Hiroaki FUJIMOTO ◽

Haruo IMAWAKA ◽

Junji KOMABA ◽

Ryuzo YAMAMOTO ◽

Seiji HIRAKU

Keyword(s):

Plasma Concentration ◽

Concentration Profile ◽

Neutrophil Elastase ◽

Enzyme Activities ◽

Bolus Administration ◽

Intravenous Bolus ◽

Metabolic Fate ◽

Neutrophil Elastase Inhibitor ◽

Elastase Inhibitor ◽

Metabolizing Enzyme

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Metabolic Fate of NKH477. (2). Blood Concentration, Distribution, Excretion and Effects on Drug-Metabolizing Enzyme System in Rats after Repeated Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.221 ◽

1998 ◽

Vol 13 (3) ◽

pp. 221-228

Author(s):

Shin-ichi MATSUMOTO ◽

Tsuyoshi IRIE ◽

Toshiko EKI ◽

Kouwa YAMASHITA ◽

Hideaki SEKI ◽

...

Keyword(s):

Intravenous Administration ◽

Blood Concentration ◽

Concentration Distribution ◽

Enzyme System ◽

Metabolic Fate ◽

Drug Metabolizing Enzyme ◽

Metabolizing Enzyme

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Studies on the Metabolic Fate of Leukotriene Antagonist ONO-1078. (2). Absorption, Distribution, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Oral Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.8.27 ◽

1993 ◽

Vol 8 (1) ◽

pp. 27-38

Author(s):

Masatsune ISHIDO ◽

Kimio SHIBAKAWA ◽

Masafumi SAWADA ◽

Hideki AISHITA

Keyword(s):

Oral Administration ◽

Enzyme Activities ◽

Metabolic Fate ◽

Drug Metabolizing Enzyme ◽

Leukotriene Antagonist ◽

Metabolizing Enzyme

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Metabolic Fate of Losartan, a New Angiotensin II Receptor Antagonist. (2). Absorption, Distribution, Metabolism, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Oral Administration in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.244 ◽

1995 ◽

Vol 10 (2) ◽

pp. 244-256 ◽

Cited By ~ 2

Author(s):

Fumio TAKAYAMA ◽

Hiroyuki ISHIZAKI ◽

Tomomi YOSHINAGA ◽

Mitsuko MORITA ◽

Shunsuke HATA ◽

...

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Enzyme Activities ◽

Angiotensin Ii Receptor ◽

Metabolic Fate ◽

Angiotensin Ii Receptor Antagonist ◽

Drug Metabolizing Enzyme ◽

Metabolizing Enzyme

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