Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na (1): Plasma Concentration-profile, Distribution and Excretion after Single Intravenous Administration to Rats.

Hiroaki FUJIMOTO; Haruo IMAWAKA; Junji KOMABA; Ryuzo YAMAMOTO; Seiji HIRAKU

doi:10.2133/dmpk.12.551

Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na (1): Plasma Concentration-profile, Distribution and Excretion after Single Intravenous Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.551 ◽

1997 ◽

Vol 12 (6) ◽

pp. 551-565 ◽

Cited By ~ 1

Author(s):

Hiroaki FUJIMOTO ◽

Haruo IMAWAKA ◽

Junji KOMABA ◽

Ryuzo YAMAMOTO ◽

Seiji HIRAKU

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Profile ◽

Neutrophil Elastase ◽

Metabolic Fate ◽

Neutrophil Elastase Inhibitor ◽

Elastase Inhibitor ◽

Profile Distribution ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na. (5): Plasma Concentration-Profile after Intravenous Bolus Administration or Intravenous Infusion to Rats and Dogs.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.28 ◽

1998 ◽

Vol 13 (1) ◽

pp. 28-35

Author(s):

Hiroaki FUJIMOTO ◽

Tetsuya SHINTANI ◽

Mayumi TAKAMOTO ◽

Ryuzo YAMAMOTO ◽

Seiji HIRAKU

Keyword(s):

Plasma Concentration ◽

Concentration Profile ◽

Neutrophil Elastase ◽

Intravenous Infusion ◽

Bolus Administration ◽

Intravenous Bolus ◽

Metabolic Fate ◽

Neutrophil Elastase Inhibitor ◽

Elastase Inhibitor

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Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na (2): Plasma concentration-profile, Distribusion and Excretion after Repeated Intravenous Bolus Administration to Rats and Effects on Metabolizing Enzyme Activities.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.566 ◽

1997 ◽

Vol 12 (6) ◽

pp. 566-575 ◽

Cited By ~ 1

Author(s):

Hiroaki FUJIMOTO ◽

Haruo IMAWAKA ◽

Junji KOMABA ◽

Ryuzo YAMAMOTO ◽

Seiji HIRAKU

Keyword(s):

Plasma Concentration ◽

Concentration Profile ◽

Neutrophil Elastase ◽

Enzyme Activities ◽

Bolus Administration ◽

Intravenous Bolus ◽

Metabolic Fate ◽

Neutrophil Elastase Inhibitor ◽

Elastase Inhibitor ◽

Metabolizing Enzyme

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Studies on the Metabolic Fate of Ultra Short Acting .BETA.1 Blocker ONO-1101. (1). Plasma Concentration-time Profile, Distribution and Excretion after Single Intravenous Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.5 ◽

1997 ◽

Vol 12 (1) ◽

pp. 5-21 ◽

Cited By ~ 1

Author(s):

Ken TSUNEKAWA ◽

Haruo IMAWAKA ◽

Hiroaki FUJIMOTO ◽

Masatsune ISHIDO ◽

Kimio SHIBAKAWA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Time Profile ◽

Metabolic Fate ◽

Short Acting ◽

Concentration Time ◽

Profile Distribution ◽

Single Intravenous Administration

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Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (1): Blood or plasma concentration, distribution, metabolism and excretion in rats after single intravenous administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.3.309 ◽

1988 ◽

Vol 3 (3) ◽

pp. 309-329 ◽

Cited By ~ 1

Author(s):

Seiu IIDA ◽

Masato IWAMOTO ◽

Masayuki SUZUKI ◽

Noriko HISANAGA ◽

Naoki TSUJII ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intravenous Administration ◽

Human Tissue ◽

Concentration Distribution ◽

Metabolic Fate ◽

Tissue Plasminogen ◽

Single Intravenous Administration

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Metabolic Fate of Roxatidine Acetate Hydrochloride. (9). Blood and Plasma Concentration, Tissue Distribution and Excretion in Male Rat after a Single Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.743 ◽

1995 ◽

Vol 10 (6) ◽

pp. 743-765

Author(s):

Kaoru UEDA ◽

Hiroyuki OCHIAI ◽

Yoshihiro KAWABE ◽

Seijiro HONMA ◽

Kunio TSUKAMOTO

Keyword(s):

Plasma Concentration ◽

Tissue Distribution ◽

Intravenous Administration ◽

Male Rat ◽

Metabolic Fate ◽

Roxatidine Acetate ◽

Single Intravenous Administration ◽

Acetate Hydrochloride

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Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na(4): Feto-Placental Transfer and Excretion into Milk.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.589 ◽

1997 ◽

Vol 12 (6) ◽

pp. 589-595 ◽

Cited By ~ 1

Author(s):

Hiroaki FUJIMOTO ◽

Junji KOMABA ◽

Ryuzo YAMAMOTO ◽

Seiji HIRAKU

Keyword(s):

Neutrophil Elastase ◽

Placental Transfer ◽

Metabolic Fate ◽

Neutrophil Elastase Inhibitor ◽

Elastase Inhibitor

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Studies on the Metabolic Fate of M17055, a Novel Diuretic. (1): Plasma Concentration and Excretion of Radioactivity in Rat and Dog after a Single Intravenous Administration of [14C]M17055.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.16.304 ◽

2001 ◽

Vol 16 (4) ◽

pp. 304-313

Author(s):

Hiroyuki NAKAJIMA ◽

Takeshi NAKANISHI ◽

Hiroyasu NABA ◽

Hiroyuki TANAKA ◽

Keiichi IDA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Metabolic Fate ◽

Single Intravenous Administration

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Metabolic Fate of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate(alendronate). (II). Plasma Concentration, Distribution and Excretion after Repeated Intravenous Administration to 7-week Old Rats and after Single Intravenous Administration to 30-week Old Rats, and Transfer into the Fetus and Milk in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.174 ◽

1995 ◽

Vol 10 (2) ◽

pp. 174-189 ◽

Cited By ~ 3

Author(s):

Tsutomu MOCHIZUKI ◽

Shin-ichi NISHIMURA ◽

Koichiro OKABE ◽

Yoshiaki AZUMA ◽

Shin UMEDA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Old Rats ◽

Single Intravenous Administration

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Metabolic Fate of YM866, a Novel Fibrinolytic Agent (I). Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Single Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.1 ◽

1996 ◽

Vol 11 (1) ◽

pp. 1-10

Author(s):

Keishi OIKAWA ◽

Hidetaka KAMIMURA ◽

Takashi WATANABE ◽

Ikuo MIYAMOTO ◽

Saburo HIGUCHI

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Fibrinolytic Agent ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na(3): Metabolism and Binding to Serum Protein in Various Animal Species.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.576 ◽

1997 ◽

Vol 12 (6) ◽

pp. 576-588 ◽

Cited By ~ 1

Author(s):

Hiroaki FUJIMOTO ◽

Haruo IMAWAKA ◽

Susumu NAKADE ◽

Ryuzo YAMAMOTO ◽

Seiji HIRAKU

Keyword(s):

Serum Protein ◽

Neutrophil Elastase ◽

Animal Species ◽

Metabolic Fate ◽

Neutrophil Elastase Inhibitor ◽

Elastase Inhibitor

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