Glucocorticoid Receptor Transactivation is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma: A Deleterious Effect of Chronic Glucocorticoid Therapy

2018 ◽  
Author(s):  
Gaurang C. Patel ◽  
J. Cameron Millar ◽  
Abbot F. Clark
Keyword(s):  
Glucocorticoid Receptor ◽  
Ocular Hypertension ◽  
Deleterious Effect ◽  
Glucocorticoid Therapy ◽  
Receptor Transactivation

scholarly journals Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma

2019 ◽  
Vol 60 (6) ◽  
pp. 1967 ◽  
Author(s):  
Gaurang C. Patel ◽  
J. Cameron Millar ◽  
Abbot F. Clark
Keyword(s):  
Glucocorticoid Receptor ◽  
Ocular Hypertension ◽  
Receptor Transactivation

scholarly journals Elevated Glucocorticoid Receptor Concentrations before and after Glucocorticoid Therapy in Peripheral Mononuclear Leukocytes of Patients with Atopic Dermatitis

Dermatology ◽  
1991 ◽  
Vol 183 (2) ◽  
pp. 100-105 ◽  
Author(s):  
M. Rupprecht ◽  
R. Rupprecht ◽  
J. Kornhuber ◽  
N. Wodarz ◽  
H.U. Koch ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Glucocorticoid Receptor ◽  
Glucocorticoid Therapy ◽  
Mononuclear Leukocytes ◽  
Before And After

scholarly journals Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension in mice

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Gaurang C. Patel ◽  
Yang Liu ◽  
J. Cameron Millar ◽  
Abbot F. Clark
Keyword(s):  
Glucocorticoid Receptor ◽  
Ocular Hypertension

A Structural Explanation of the Effects of Dissociated Glucocorticoids on Glucocorticoid Receptor Transactivation

2013 ◽  
Vol 85 (2) ◽  
pp. 226-236 ◽  
Author(s):  
Xavier Dezitter ◽  
Jérôme Fagart ◽  
Solenne Taront ◽  
Michel Fay ◽  
Bernadette Masselot ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Structural Explanation ◽  
Receptor Transactivation

The effects of glucocorticoid therapy on glucocorticoid receptors in leukemia and lymphoma

Blood ◽  
1981 ◽  
Vol 58 (6) ◽  
pp. 1198-1202
Author(s):  
GF Shipman ◽  
CD Bloomfield ◽  
KA Smith ◽  
BA Peterson ◽  
A Munck
Keyword(s):  
Glucocorticoid Receptor ◽  
Peripheral Blood ◽  
Glucocorticoid Receptors ◽  
Glucocorticoid Therapy ◽  
Malignant Cells ◽  
Initial Number ◽  
Receptor Sites ◽  
Receptor Number

Measurement of glucocorticoid receptors appears to be useful for selecting which patients with leukemia and lymphoma should receive glucocorticoid therapy. To determine the effect of recent or concurrent glucocorticoid therapy on the number of measured tumor glucocorticoid receptor sites, 18 patients with leukemia and lymphoma were studied. Baseline determinations of numbers of glucocorticoid receptors were performed on the malignant cells circulating in the patients' peripheral blood. Glucocorticoid therapy was then instituted consisting of dexamethasone 4 mg p.o. every 6 hr. Repeat determinations of the number of glucocorticoid receptor sites were performed within 24 hr and at various subsequent times from the start of therapy. When compared to baseline receptor numbers, 16 of 18 patients demonstrated a decrease in receptor number (median decrease 1651 sites/cell) after the start of glucocorticoid therapy. The magnitude of the change in receptor number was independent on the initial number of receptors. Our results suggest that in order accurately interpret glucocorticoid receptor numbers in patients with leukemia and lymphoma, glucocorticoid should not be administered for 3 wk prior to determinations of receptor levels.

scholarly journals Glucocorticoid therapy and ocular hypertension

2016 ◽  
Vol 787 ◽  
pp. 57-71 ◽  
Author(s):  
Adnan Dibas ◽  
Thomas Yorio
Keyword(s):  
Ocular Hypertension ◽  
Glucocorticoid Therapy
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