Cholesterol and Matrisome Pathways Dysregulated in Human APOE ∊4 Glia

2019 ◽  
Author(s):  
Julia TCW ◽  
Shuang A. Liang ◽  
Lu Qian ◽  
Nina H. Pipalia ◽  
Michael J. Chao ◽  
...  
Keyword(s):  
Human Apoe

scholarly journals Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41636 ◽  
Author(s):  
Cheryl A. Hawkes ◽  
Patrick M. Sullivan ◽  
Sarah Hands ◽  
Roy O. Weller ◽  
James A. R. Nicoll ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Human Apoe ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
Perivascular Drainage

P1-283: The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ∊2, ∊3 and ∊4 knock-in mice

2010 ◽  
Vol 6 ◽  
pp. S255-S256
Author(s):  
Wei Ling Florence Lim ◽  
Andrew M. Jenner ◽  
Mary Pei Ern Ng ◽  
Markus R. Wenk ◽  
Guanghou Shui ◽  
...  
Keyword(s):  
Apoe Genotype ◽  
Human Apoe ◽  
Brain Levels

scholarly journals Characterizing the human APOE epsilon 4 knock-in transgene in female and male rats with multimodal magnetic resonance imaging

2020 ◽  
Vol 1747 ◽  
pp. 147030 ◽  
Author(s):  
Praveen Kulkarni ◽  
Simone Grant ◽  
Thomas R. Morrison ◽  
Xuezhu Cai ◽  
Sade Iriah ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Male Rats ◽  
Resonance Imaging ◽  
Human Apoe

scholarly journals Introducing HumanAPOEinto AβTransgenic Mouse Models

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Leon M. Tai ◽  
Katherine L. Youmans ◽  
Lisa Jungbauer ◽  
Chunjiang Yu ◽  
Mary Jo LaDu
Keyword(s):  
Head Injury ◽  
Mouse Models ◽  
Disease Risk ◽  
Rapid Onset ◽  
Temporal Delay ◽  
Wild Type ◽  
Significant Delay ◽  
Human Apoe ◽  
Plaque Deposition ◽  
5Xfad Mice

Apolipoprotein E (apoE) and apoE/amyloid-β(Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk. Compared to wild type,apoE−/−mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-independent apoE effects on neurodegeneration. To determine the effects of apoE on Aβ-induced neuropathology,apoE−/−mice were crossed with Aβ-Tg mice, resulting in a significant delay in plaque deposition. Surprisingly, crossing human-apoE-Tg mice withapoE−/−/Aβ-Tg mice further delayed plaque deposition, which eventually developed in apoE4/Aβ-Tg mice prior to apoE3/Aβ-Tg. One approach to address hAPOE-induced temporal delay in Aβpathology is an additional insult, like head injury. Another is crossing human-apoE-Tg mice with Aβ-Tg mice that have rapid-onset Aβpathology. For example, because 5xFAD mice develop plaques by 2 months, the prediction is that human-apoE/5xFAD-Tg mice develop plaques around 6 months and 12 months before other human-apoE/Aβ-Tg mice. Thus, tractable models for human-apoE/Aβ-Tg mice continue to evolve.

scholarly journals Human APOE Isoform-Dependent Effects on Brain  -Amyloid Levels in PDAPP Transgenic Mice

2009 ◽  
Vol 29 (21) ◽  
pp. 6771-6779 ◽  
Author(s):  
K. R. Bales ◽  
F. Liu ◽  
S. Wu ◽  
S. Lin ◽  
D. Koger ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Human Apoe

Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing age

2005 ◽  
Vol 229-230 ◽  
pp. 225-232 ◽  
Author(s):  
U. Igbavboa ◽  
G.P. Eckert ◽  
T.M. Malo ◽  
A.E. Studniski ◽  
L.N.A. Johnson ◽  
...  
Keyword(s):  
Lipid Raft ◽  
Lipid Composition ◽  
Human Apoe

scholarly journals O5-01-03: Epigenetic signature of the human APOE gene: Implications in Alzheimer's disease

2013 ◽  
Vol 9 ◽  
pp. P828-P829
Author(s):  
Chang-En Yu ◽  
Lynn Bekris ◽  
Zachary Thomson ◽  
Lesley Leong ◽  
Franziska Lutz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apoe Gene ◽  
Human Apoe

The Genetics of the Human APOE Polymorphism

2011 ◽  
Vol 14 (5) ◽  
pp. 491-500 ◽  
Author(s):  
Davide Seripa ◽  
Grazia D'Onofrio ◽  
Francesco Panza ◽  
Leandro Cascavilla ◽  
Carlo Masullo ◽  
...  
Keyword(s):  
Apoe Polymorphism ◽  
Human Apoe

Is ϵ4 the ancestral human apoE allele?

1999 ◽  
Vol 20 (4) ◽  
pp. 429-430 ◽  
Author(s):  
Robert W Mahley ◽  
Stanley C Rall
Keyword(s):  
Apoe Allele ◽  
Human Apoe

Regionally specific neuronal expression of human APOE gene in transgenic mice

1998 ◽  
Vol 246 (2) ◽  
pp. 65-68 ◽  
Author(s):  
Pu-Ting Xu ◽  
John R Gilbert ◽  
Hui-Ling Qiu ◽  
Tracie Rothrock-Christian ◽  
Daniel L Settles ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Apoe Gene ◽  
Human Apoe ◽  
Neuronal Expression
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