Effect of Jet Lag on Brain White Matter Functional Connectivity

2020 ◽  
Author(s):  
Feifei Zhang ◽  
Zhipeng Yang ◽  
Kun Qin ◽  
John A. Sweeney ◽  
Neil Roberts ◽  
...  
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
Jet Lag ◽  
Brain White Matter

scholarly journals Effect of jet lag on brain white matter functional connectivity

2021 ◽  
Vol 1 (2) ◽  
pp. 55-65
Author(s):  
Feifei Zhang ◽  
Zhipeng Yang ◽  
Kun Qin ◽  
John A Sweeney ◽  
Neil Roberts ◽  
...  
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
Complex Problem ◽  
Jet Lag ◽  
Sensorimotor Network ◽  
Brain White Matter ◽  
Window Method ◽  
Time Zones ◽  
Circadian Rhythm Sleep Disorder ◽  
Sliding Window Method

Abstract Background A long-haul flight across more than five time zones may produce a circadian rhythm sleep disorder known as jet lag. Little is known about the effect of jet lag on white matter (WM) functional connectivity (FC). Objective The present study is to investigate changes in WM FC in subjects due to recovery from jet lag after flying across six time zones. Methods Here, resting-state functional magnetic resonance imaging was performed in 23 participants within 24 hours of flying and again 50 days later. Gray matter (GM) and WM networks were identified by k-means clustering. WM FC and functional covariance connectivity (FCC) were analyzed. Next, a sliding window method was used to establish dynamic WM FC. WM static and dynamic FC and FCC were compared between when participants had initially completed their journey and 50 days later. Emotion was assessed using the Positive and Negative Affect Schedule and the State Anxiety Inventory. Results All participants were confirmed to have jet lag symptoms by the Columbian Jet Lag Scale. The static FC strengthes of cingulate network (WM7)- sensorimotor network and ventral frontal network- visual network were lower after the long-haul flight compared with recovery. Corresponding results were obtained for the dynamic FC analysis. The analysis of FCC revealed weakened connections between the WM7 and several other brain networks, especially the precentral/postcentral network. Moreover, a negative correlation was found between emotion scores and the FC between the WM7 and sensorimotor related regions. Conclusions The results of this study provide further evidence for the existence of WM networks and show that jet lag is associated with alterations in static and dynamic WM FC and FCC, especially in sensorimotor networks. Jet lag is a complex problem that not only is related to sleep rhythm but also influences emotion.

Effects of polygenic risk of schizophrenia on interhemispheric callosal white matter integrity and frontotemporal functional connectivity in first-episode schizophrenia

2022 ◽  
pp. 1-10
Author(s):  
Wenjun Su ◽  
Aihua Yuan ◽  
Yingying Tang ◽  
Lihua Xu ◽  
Yanyan Wei ◽  
...  
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
White Matter Integrity ◽  
First Episode ◽  
Polygenic Risk Score ◽  
Polygenic Inheritance ◽  
Polygenic Risk ◽  
Corona Radiata ◽  
Brain White Matter ◽  
First Episode Schizophrenia

Abstract Background Schizophrenia is a severely debilitating psychiatric disorder with high heritability and polygenic architecture. A higher polygenic risk score for schizophrenia (SzPRS) has been associated with smaller gray matter volume, lower activation, and decreased functional connectivity (FC). However, the effect of polygenic inheritance on the brain white matter microstructure has only been sparsely reported. Methods Eighty-four patients with first-episode schizophrenia (FES) patients and ninety-three healthy controls (HC) with genetics, diffusion tensor imaging (DTI), and resting-state functional magnetic resonance imaging (rs-fMRI) data were included in our study. We investigated impaired white matter integrity as measured by fractional anisotropy (FA) in the FES group, further examined the effect of SzPRS on white matter FA and FC in the regions connected by SzPRS-related white matter tracts. Results Decreased FA was observed in FES in many commonly identified regions. Among these regions, we observed that in the FES group, but not the HC group, SzPRS was negatively associated with the mean FA in the genu and body of corpus callosum, right anterior corona radiata, and right superior corona radiata. Higher SzPRS was also associated with lower FCs between the left inferior frontal gyrus (IFG)–left inferior temporal gyrus (ITG), right IFG–left ITG, right IFG–left middle frontal gyrus (MFG), and right IFG–right MFG in the FES group. Conclusion Higher polygenic risks are linked with disrupted white matter integrity and FC in patients with schizophrenia. These correlations are strongly driven by the interhemispheric callosal fibers and the connections between frontotemporal regions.

26. Neuroradiology: Head and Neck, Brain White Matter Imaging

2006 ◽  
Vol 186 (4_supplement) ◽  
pp. A66-A69
Keyword(s):  
White Matter ◽  
Head And Neck ◽  
Brain White Matter

Abnormal white matter functional connectivity density in antipsychotic-naive adolescents with schizophrenia

2021 ◽  
Vol 132 (5) ◽  
pp. 1025-1032
Author(s):  
Xiao Wang ◽  
Wei Liao ◽  
Shaoqiang Han ◽  
Fengmei Lu ◽  
Zongling He ◽  
...  
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
Functional Connectivity Density

scholarly journals QOL-09. WHOLE-BRAIN WHITE MATTER NETWORK CONNECTIVITY IS DISRUPTED BY PEDIATRIC BRAIN TUMOR TREATMENT

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii432-iii432
Author(s):  
Adeoye Oyefiade ◽  
Kiran Beera ◽  
Iska Moxon-Emre ◽  
Jovanka Skocic ◽  
Ute Bartels ◽  
...  
Keyword(s):  
White Matter ◽  
Pediatric Brain Tumor ◽  
Pediatric Brain Tumors ◽  
Magnetic Resonance Images ◽  
Long Term Effects ◽  
Brain White Matter ◽  
The Right ◽  
Pediatric Brain ◽  
Betweeness Centrality

Abstract INTRODUCTION Treatments for pediatric brain tumors (PBT) are neurotoxic and lead to long-term deficits that are driven by the perturbation of underlying white matter (WM). It is unclear if and how treatment may impair WM connectivity across the entire brain. METHODS Magnetic resonance images from 41 PBT survivors (mean age: 13.19 years, 53% M) and 41 typically developing (TD) children (mean age: 13.32 years, 51% M) were analyzed. Image reconstruction, segmentation, and node parcellation were completed in FreeSurfer. DTI maps and probabilistic streamline generation were completed in MRtrix3. Connectivity matrices were based on the number of streamlines connecting two nodes and the mean DTI (FA) index across streamlines. We used graph theoretical analyses to define structural differences between groups, and random forest (RF) analyses to identify hubs that reliably classify PBT and TD children. RESULTS For survivors treated with radiation, betweeness centrality was greater in the left insular (p < 0.000) but smaller in the right pallidum (p < 0.05). For survivors treated without radiation (surgery-only), betweeness centrality was smaller in the right interparietal sulcus (p < 0.05). RF analyses showed that differences in WM connectivity from the right pallidum to other parts of the brain reliably classified PBT survivors from TD children (classification accuracy = 77%). CONCLUSIONS The left insular, right pallidum, and right inter-parietal sulcus are structurally perturbed hubs in PBT survivors. WM connectivity from the right pallidum is vulnerable to the long-term effects of treatment for PBT.

scholarly journals White matter integrity and functional connectivity in adolescents with a parental history of substance use disorder

2021 ◽  
Vol 1 (3) ◽  
pp. 100037
Author(s):  
Xiaofu He ◽  
Diana V. Rodriguez-Moreno ◽  
Yael M. Cycowicz ◽  
Keely Cheslack-Postava ◽  
Huilan Tang ◽  
...  
Keyword(s):  
Substance Use ◽  
White Matter ◽  
Functional Connectivity ◽  
Substance Use Disorder ◽  
White Matter Integrity ◽  
Parental History ◽  
History Of
Sign in / Sign up

Export Citation Format

Share Document