Sacrificial Fibers Improve Matrix Distribution and Mechanical Properties in a Tissue-Engineered Intervertebral Disc

2020 ◽  
Author(s):  
Beth G. Ashinsky ◽  
Sarah E. Gullbrand ◽  
Edward D. Bonnevie ◽  
Chao Wang ◽  
Dong Hwa Kim ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Intervertebral Disc ◽  
Matrix Distribution

Influence of tissue- and cell-scale extracellular matrix distribution on the mechanical properties of tissue-engineered cartilage

2012 ◽  
Vol 12 (5) ◽  
pp. 901-913 ◽  
Author(s):  
Mehdi Khoshgoftar ◽  
Wouter Wilson ◽  
Keita Ito ◽  
Corrinus C. van Donkelaar
Keyword(s):  
Mechanical Properties ◽  
Extracellular Matrix ◽  
Matrix Distribution ◽  
Engineered Cartilage

On the Mechanical Properties of the Human Intervertebral Disc.

1978 ◽  
Author(s):  
N. D. Panagiotacopulos ◽  
R. Bloch ◽  
W. G. Knauss ◽  
P. Harvey ◽  
M. Patzakis
Keyword(s):  
Mechanical Properties ◽  
Intervertebral Disc

Sacrificial Fibers Improve Matrix Distribution and Micromechanical Properties in a Tissue-Engineered Intervertebral Disc

2020 ◽  
Vol 111 ◽  
pp. 232-241 ◽  
Author(s):  
Beth G. Ashinsky ◽  
Sarah E. Gullbrand ◽  
Edward D. Bonnevie ◽  
Chao Wang ◽  
Dong Hwa Kim ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Micromechanical Properties ◽  
Matrix Distribution

In vitro comparison between mechanical properties and elastographic characterization of porcine intervertebral disc

2015 ◽  
Vol 18 (sup1) ◽  
pp. 1906-1907
Author(s):  
Y. Chotar-Vasseur ◽  
T. Cachon ◽  
B. Ponsard ◽  
C. Carozzo ◽  
E. Viguier
Keyword(s):  
Mechanical Properties ◽  
Intervertebral Disc ◽  
In Vitro Comparison

scholarly journals Hierarchical structure and mechanical properties of collagen in the intervertebral disc

1991 ◽  
Vol 19 (3) ◽  
pp. 331-331 ◽  
Author(s):  
James Joseph Cassidy ◽  
Anne Hiltner ◽  
Eric Baer
Keyword(s):  
Mechanical Properties ◽  
Intervertebral Disc ◽  
Hierarchical Structure

scholarly journals Multi-Scale Structural and Tensile Mechanical Response of Annulus Fibrosus to Osmotic Loading

2012 ◽  
Author(s):  
Woojin M. Han ◽  
Nandan L. Nerurkar ◽  
Lachlan J. Smith ◽  
Nathan T. Jacobs ◽  
Robert L. Mauck ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Intervertebral Disc ◽  
Mechanical Testing ◽  
Biochemical Composition ◽  
Annulus Fibrosus ◽  
Mechanical Response ◽  
Tissue Level ◽  
Multi Scale ◽  
Osmotic Loading

The annulus fibrosus (AF) is a multi-lamellar fibrocartilagenous ring in the intervertebral disc. The variation of biochemical composition from the outer to the inner AF is largely responsible for the heterogeneous mechanical properties. In vitro tissue-level studies require mechanical testing in aqueous buffers to avoid tissue dehydration. The varying glycosaminoglycan (GAG) contents from outer to inner AF suggest that the response to high and low PBS osmolarity may also be different with radial position. Previous studies in tendon and ligament have been conflicting: soaking tendon fascicles in PBS decreased tensile modulus1 and treating ligament in buffer had no effect on modulus.2

Intra- and Extrafibrillar Fluid Exchange in the Disc

2007 ◽  
Author(s):  
Y. Schroeder ◽  
S. Sivan ◽  
W. Wilson ◽  
J. M. Huyghe ◽  
A. Maroudas ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Intervertebral Disc ◽  
Water Content ◽  
Biochemical Composition ◽  
Mechanical Load ◽  
Crack Opening ◽  
Cellular Responses ◽  
Fluid Exchange ◽  
External Mechanical Load

The mechanical properties of the intervertebral disc are regulated by its biochemical composition. With ageing and degeneration the water content of the disc decreases which highly influences the mechanical properties. The disc is subjected to a combination of elastic, viscous and osmotic forces. Osmotic forces are shown to have a major impact on crack opening and propagation [1] and on cellular responses [2]. In particular, osmosis provides an understanding on why fissures in the degenerating disc are so poorly related to external mechanical load [3].

scholarly journals Collagen gene expression and mechanical properties of intervertebral disc cell–alginate cultures

2001 ◽  
Vol 19 (1) ◽  
pp. 2-10 ◽  
Author(s):  
Anthony E. Baer ◽  
Jean Y. Wang ◽  
Virginia B. Kraus ◽  
Lori A. Setton
Keyword(s):  
Gene Expression ◽  
Mechanical Properties ◽  
Intervertebral Disc ◽  
Disc Cell ◽  
Collagen Gene ◽  
Collagen Gene Expression

scholarly journals Fabrication of a novel whole tissue-engineered intervertebral disc for intervertebral disc regeneration in the porcine lumbar spine

RSC Advances ◽  
2018 ◽  
Vol 8 (68) ◽  
pp. 39013-39021 ◽  
Author(s):  
Fei Yang ◽  
Dongqin Xiao ◽  
Qiao Zhao ◽  
Zhu Chen ◽  
Kang Liu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Lumbar Spine ◽  
Intervertebral Disc ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration

A novel whole tissue-engineered IVD consisting of a triphasic scaffold demonstrated excellent biocompatibility and mechanical properties in the porcine lumbar spine.

Three-Dimensional-Printed Flexible Scaffolds Have Tunable Biomimetic Mechanical Properties for Intervertebral Disc Tissue Engineering

2021 ◽  
Author(s):  
Samantha L. Marshall ◽  
Timothy D. Jacobsen ◽  
Erik Emsbo ◽  
Archana Murali ◽  
Kevin Anton ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Intervertebral Disc ◽  
Three Dimensional ◽  
Disc Tissue
Sign in / Sign up

Export Citation Format

Share Document