Dual Space Arguments Using Polynomial Roots in the Complex Plane: A Novel Approach to Deriving Key Statistical Results

2020 ◽  
Author(s):  
Timothy Falcon Crack ◽  
Michael J. Osborne ◽  
Malcolm Crack ◽  
Mark Osborne
Keyword(s):  
Complex Plane ◽  
Dual Space ◽  
Polynomial Roots ◽  
Novel Approach ◽  
Statistical Results

Finding polynomial roots: A fast algorithm convergent on the complex plane

1985 ◽  
Vol 1 (6) ◽  
pp. 287-291 ◽  
Author(s):  
Andrey V. Ivanisov ◽  
Vadim K. Polishchuk
Keyword(s):  
Complex Plane ◽  
Fast Algorithm ◽  
Polynomial Roots

Statistical results on discovered near-Earth asteroids

1999 ◽  
Vol 173 ◽  
pp. 81-86
Author(s):  
S. Berinde
Keyword(s):  
Dynamical Evolution ◽  
Minor Planet ◽  
Orbital Elements ◽  
The Earth ◽  
Near Earth Asteroids ◽  
Statistical Results

AbstractThe first part of this paper gives a recent overview (until July 1st, 1998) of the Near-Earth Asteroids (NEAs) database stored at Minor Planet Center. Some statistical interpretations point out strong observational biases in the population of discovered NEAs, due to the preferential discoveries, depending on the objects’ distances and sizes. It is known that many newly discovered NEAs have no accurately determinated orbits because of the lack of observations. Consequently, it is hard to speak about future encounters and collisions with the Earth in terms of mutual distances between bodies. Because the dynamical evolution of asteroids’ orbits is less sensitive to the improvement of their orbital elements, we introduced a new subclass of NEAs named Earth-encounter asteroids in order to describe more reliably the potentially dangerous bodies as impactors with the Earth. So, we pay attention at those asteroids having an encounter between their orbits and that of the Earth within 100 years, trying to classify these encounters.

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

Abstract #709: E-Consults: A Novel Approach to Increase Access to Subspecialty Care in Endocrinology

2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
...  
Keyword(s):  
Novel Approach

MacArthur Foundation: young giant takes a novel approach to research

1983 ◽  
Author(s):  
Kathleen Fisher ◽  
Keyword(s):  
Novel Approach ◽  
Macarthur Foundation

Novel approach offers hope for treating severe disorders

1997 ◽  
Author(s):  
Scott Sleek
Keyword(s):  
Novel Approach
Sign in / Sign up

Export Citation Format

Share Document