Current View on Convalescent Plasma Therapy for COVID-19 Treatment: A Systematic Review and Prospective Meta-Analysis Based on Previous Respiratory Pandemics

2020 ◽  
Author(s):  
Jenifer Kiem Aviani ◽  
Danny Halim ◽  
Alya Mardhotillah Azizah ◽  
Ika Adhani Sholihah ◽  
Arto Yuwono Soeroto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Current View ◽  
Plasma Therapy

scholarly journals The Effect of Convalescent Plasma Therapy on COVID-19 Patient Mortality: Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Stephen A. Klassen ◽  
Jonathon W. Senefeld ◽  
Patrick W. Johnson ◽  
Rickey E. Carter ◽  
Chad C. Wiggins ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Plasma Therapy

scholarly journals Convalescent Plasma Therapy in Severe and Critically Ill COVID-19 Patients: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Penglei Yang ◽  
Jing Wang ◽  
Ruiqiang Zheng ◽  
Rui Tan ◽  
Xianghui Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Critically Ill ◽  
Virus Disease ◽  
Therapy Group ◽  
Meta Analysis ◽  
Control Group ◽  
Plasma Therapy ◽  
Risk Of Death ◽  
Randomized Controlled ◽  
Randomized Controlled Studies

Abstract Background: Convalescent plasma treatment of severe and critically ill Corona Virus Disease 2019(COVID-19) patients is still controversial.Objective: To evaluate the efficacy and safety of convalescent plasma in patients with severe COVID-19 infection and critically ill patients, We performed a meta-analysis and systematic review of convalescent plasma therapy in severe and critically ill COVID-19 patients.Methods: We conducted a literature search in electronic data and citations of previously published systematic reviews. We included only randomized controlled studies on convalescent plasma for the treatment of severe and critically ill COVID-19 patients. Results: A total of 7 randomized controlled trials and 1363 patients were included in the meta-analysis. Compared to patients of the control group, there was no difference in clinical improvement (Four studies, RR 1.06, 95% CI 0.96 to 1.17, p = 0.22, moderate certainty) and mortality (seven studies, RR 0.86, 95% CI 0.66 to 1.11, p = 0.48, moderate certainty) for patients of convalescent plasma therapy group.Conclusion: Convalescent plasma does not reduce the improvement of symptoms and the risk of death in severely infected and critically ill COVID-19 patients

scholarly journals Efficacy of convalescent plasma therapy for COVID ‐19: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Charan T. R. Vegivinti ◽  
John M. Pederson ◽  
Kavitha Saravu ◽  
Nitin Gupta ◽  
Kirk W. Evanson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Plasma Therapy

scholarly journals Convalescent Plasma in the Treatment of Severe COVID-19: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Xuanguo ZHANG ◽  
Li XI ◽  
Fang PANG ◽  
Yan DU ◽  
Qiuzhen YUAN ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Reactions ◽  
Clinical Evidence ◽  
Meta Analysis ◽  
Clinical Trial Data ◽  
Incidence Rates ◽  
Knowledge Network ◽  
Eligibility Criteria ◽  
Plasma Therapy ◽  
Systematic Analysis

Background: COVID-19 is a public health emergency of international concern. Its incidence rates and mortality are very high; however, so far, an effective drug treatment remains unknown. Based on the role of convalescent plasma therapy in previously identified viral pneumonias, patients with severe COVID-19 have been given this therapy. This systematic review and meta-analysis aimed to summarize the clinical evidence regarding the efficacy and safety of convalescent plasma therapy in the treatment of severe COVID-19. Methods: PubMed, Embase, Ovid, China Knowledge Network, China Biomedical, VIP Chinese Sci-tech Journal, Wanfang Database, and the International Clinical Trials Registry Platform were searched up to 21 June 2020, to identify clinical studies and registered trials on the use of convalescent plasma in the treatment of critically ill patients with COVID-19. Stata 13.0 was used to perform Meta-analysis. All records were screened as per the protocol eligibility criteria. Results: Nineteen clinical reports regarding convalescent plasma in the treatment of severe COVID-19 were included. Through systematic analysis, convalescent plasma was found to yield some efficacy on severe COVID-19 and had almost no obvious adverse reactions. Conclusion: Convalescent plasma therapy seems to yield some efficacy among patients with severe COVID-19 and almost no obvious adverse reactions were found. However, at present, the clinical evidence is insufficient, and there is an urgent need for support from high-quality clinical trial data.  

Effectiveness of platelet-rich plasma therapy in wound healing of pilonidal sinus surgery: A comprehensive systematic review and meta-analysis

2017 ◽  
Vol 25 (6) ◽  
pp. 1002-1007 ◽  
Author(s):  
Shayan Mostafaei ◽  
Fatemeh Norooznezhad ◽  
Saeed Mohammadi ◽  
Amir Hossein Norooznezhad
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Pilonidal Sinus ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Sinus Surgery ◽  
Plasma Therapy

scholarly journals PLATELET-RICH PLASMA THERAPY FOR ERECTILE DYSFUNCTION: A REVIEW OF PRECLINICAL AND CLINICAL STUDIES

2019 ◽  
Vol 6 (3) ◽  
pp. 74-86
Author(s):  
A. D. Kaprin ◽  
A. A. Kostin ◽  
M. V. Epifanova ◽  
M. E. Chalyy ◽  
E. V. Gameeva ◽  
...  
Keyword(s):  
Systematic Review ◽  
Erectile Dysfunction ◽  
Clinical Studies ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Current Data ◽  
Cochrane Library ◽  
Multicenter Studies ◽  
Plasma Therapy ◽  
Preclinical And Clinical Studies

Erectile dysfunction is no longer a psychosocial problem. Nowadays, it is a marker specific for the initial stages of cardiovascular diseases. Рlatelet-rich plasma (PRP) is a new and promising method, which totally deserves to be noted by specialists. To review currently existing pre-clinical and clinical studies concerning application of PRP in erectile dysfunction published in international sources such as PubMed, Cochrane Library, Clinicaltrials.gov. The current data of preclinical and clinical studies determine the absence of PRP side effects and the effectiveness for ED treatment. PRP-therapy is a pathogenetically substantiated method of treating erectile dysfunction. The therapy is designed for repair and regeneration of endothelium, smooth muscle cells, and connective tissue. However, large, placebo-controlled, multicenter studies are needed to creation a systematic review and meta-analysis.

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