scholarly journals A potentially effective treatment for COVID-19: A systematic review and meta-analysis of convalescent plasma therapy in treating severe infectious disease

2020 ◽  
Vol 98 ◽  
pp. 334-346 ◽  
Author(s):  
Mengyao Sun ◽  
Yinghui Xu ◽  
Hua He ◽  
Li Zhang ◽  
Xu Wang ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Systematic Review ◽  
Effective Treatment ◽  
Meta Analysis ◽  
Plasma Therapy

scholarly journals The Effect of Convalescent Plasma Therapy on COVID-19 Patient Mortality: Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Stephen A. Klassen ◽  
Jonathon W. Senefeld ◽  
Patrick W. Johnson ◽  
Rickey E. Carter ◽  
Chad C. Wiggins ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Plasma Therapy

scholarly journals Convalescent Plasma Therapy in Severe and Critically Ill COVID-19 Patients: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Penglei Yang ◽  
Jing Wang ◽  
Ruiqiang Zheng ◽  
Rui Tan ◽  
Xianghui Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Critically Ill ◽  
Virus Disease ◽  
Therapy Group ◽  
Meta Analysis ◽  
Control Group ◽  
Plasma Therapy ◽  
Risk Of Death ◽  
Randomized Controlled ◽  
Randomized Controlled Studies

Abstract Background: Convalescent plasma treatment of severe and critically ill Corona Virus Disease 2019(COVID-19) patients is still controversial.Objective: To evaluate the efficacy and safety of convalescent plasma in patients with severe COVID-19 infection and critically ill patients, We performed a meta-analysis and systematic review of convalescent plasma therapy in severe and critically ill COVID-19 patients.Methods: We conducted a literature search in electronic data and citations of previously published systematic reviews. We included only randomized controlled studies on convalescent plasma for the treatment of severe and critically ill COVID-19 patients. Results: A total of 7 randomized controlled trials and 1363 patients were included in the meta-analysis. Compared to patients of the control group, there was no difference in clinical improvement (Four studies, RR 1.06, 95% CI 0.96 to 1.17, p = 0.22, moderate certainty) and mortality (seven studies, RR 0.86, 95% CI 0.66 to 1.11, p = 0.48, moderate certainty) for patients of convalescent plasma therapy group.Conclusion: Convalescent plasma does not reduce the improvement of symptoms and the risk of death in severely infected and critically ill COVID-19 patients

scholarly journals Diagnostic Infectious Diseases Testing Outside Clinics: A Global Systematic Review and Meta-analysis

2020 ◽  
Vol 7 (10) ◽  
Author(s):  
Eneyi E Kpokiri ◽  
Gifty Marley ◽  
Weiming Tang ◽  
Noah Fongwen ◽  
Dan Wu ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Systematic Review ◽  
Meta Analysis ◽  
Diagnostic Testing ◽  
Linkage To Care ◽  
Adverse Outcomes ◽  
Moderate Quality ◽  
Self Testing ◽  
The Impact ◽  
Delivery Models

Abstract Background Most people around the world do not have access to facility-based diagnostic testing, and the gap in availability of diagnostic tests is a major public health challenge. Self-testing, self-sampling, and institutional testing outside conventional clinical settings are transforming infectious disease diagnostic testing in a wide range of low- and middle-income countries (LMICs). We examined the delivery models of infectious disease diagnostic testing outside clinics to assess the impact on test uptake and linkage to care. Methods We conducted a systematic review and meta-analysis, searching 6 databases and including original research manuscripts comparing testing outside clinics with conventional testing. The main outcomes were test uptake and linkage to care, delivery models, and adverse outcomes. Data from studies with similar interventions and outcomes within thematic areas of interest were pooled, and the quality of evidence was assessed using GRADE. This study was registered in PROSPERO (CRD42019140828). We identified 10 386 de-duplicated citations, and 76 studies were included. Data from 18 studies were pooled in meta-analyses. Studies focused on HIV (48 studies), chlamydia (8 studies), and multiple diseases (20 studies). HIV self-testing increased test uptake compared with facility-based testing (9 studies: pooled odds ratio [OR], 2.59; 95% CI, 1.06–6.29; moderate quality). Self-sampling for sexually transmitted infections increased test uptake compared with facility-based testing (7 studies: pooled OR, 1.74; 95% CI, 0.97–3.12; moderate quality). Conclusions.  Testing outside of clinics increased test uptake without significant adverse outcomes. These testing approaches provide an opportunity to expand access and empower patients. Further implementation research, scale-up of effective service delivery models, and policies in LMIC settings are needed.

Current View on Convalescent Plasma Therapy for COVID-19 Treatment: A Systematic Review and Prospective Meta-Analysis Based on Previous Respiratory Pandemics

2020 ◽  
Author(s):  
Jenifer Kiem Aviani ◽  
Danny Halim ◽  
Alya Mardhotillah Azizah ◽  
Ika Adhani Sholihah ◽  
Arto Yuwono Soeroto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Current View ◽  
Plasma Therapy

Experiences of Using Positive Airway Pressure for Treatment of Obstructive Sleep Apnoea: A Systematic Review and Thematic Synthesis

SLEEP ◽  
2021 ◽  
Author(s):  
Amy Brown ◽  
Steven Jones ◽  
Guillermo Perez-Algorta
Keyword(s):  
Systematic Review ◽  
Effective Treatment ◽  
Obstructive Sleep Apnoea ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Meta Analysis ◽  
Service Level ◽  
Sleep Apnoea ◽  
Thematic Synthesis ◽  
Obstructive Sleep

Abstract Study objectives Sub-optimal use of positive airway pressure (PAP) to treat obstructive sleep apnoea (OSA) continues to be a major challenge to effective treatment. Meanwhile, the individual and societal impacts of untreated OSA make effective treatment a priority. Although extensive research has been conducted into factors that impact PAP use, it is estimated that at least half of users do not use it as prescribed. However, the voice of users is notably minimal in the literature. A systematic review and qualitative metasynthesis of PAP user experience was conducted to contribute to understandings of how PAP is experienced and to inform how usage could be improved. Methods PsycINFO, MEDLINE, CINAHL and EMBASE databases were systematically searched. Primary research findings of adult experiences using PAP that had been inductively analysed were included. Papers were critically appraised using the CASP qualitative checklist to generate a “hierarchy of evidence”. Thematic synthesis was then conducted to generate analytical themes. Results were presented in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Results 25 papers reporting on over 398 people’s experiences were analysed to generate 4 themes: Journey to PAP, Discomfort from and around PAP, Adapting to and using PAP, and Benefits from PAP. Author reflexivity and vulnerability to bias is acknowledged. Conclusions The findings highlight the applicability of a biopsychosocial understanding to PAP use. This metasynthesis gave voice to user experiences, revealing barriers to PAP use at a healthcare service level across the world, and suggests ways services can address these barriers.

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