Effects of infusion of glucose-insulin-potassium on myocardial function after a recent myocardial infarction

2000 ◽  
Vol 55 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Lidia MARANO ◽  
Alberto BESTETTI ◽  
Alberto LOMUSCIO ◽  
Luca TAGLIABUE ◽  
Diego CASTINI ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Myocardial Function ◽  
Recent Myocardial Infarction

scholarly journals Intravenous diazoxide in treatment of hypertension associated with recent myocardial infarction

BMJ ◽  
1975 ◽  
Vol 4 (5988) ◽  
pp. 74-77 ◽  
Author(s):  
K P O'Brien ◽  
R R Grigor ◽  
P M Taylor
Keyword(s):  
Myocardial Infarction ◽  
Recent Myocardial Infarction ◽  
Treatment Of Hypertension

scholarly journals Effect of cardiosphere-derived cells on segmental myocardial function after myocardial infarction: ALLSTAR randomised clinical trial

Open Heart ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. e001614
Author(s):  
Mohammad R Ostovaneh ◽  
Raj R Makkar ◽  
Bharath Ambale-Venkatesh ◽  
Deborah Ascheim ◽  
Tarun Chakravarty ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Clinical Trial ◽  
Myocardial Function ◽  
Randomised Clinical Trial ◽  
Scar Tissue ◽  
Left Ventricular ◽  
Lv Function ◽  
Cardiac Events ◽  
Lv Dysfunction ◽  
Registration Number

BackgroundMost cell therapy trials failed to show an improvement in global left ventricular (LV) function measures after myocardial infarction (MI). Myocardial segments are heterogeneously impacted by MI. Global LV function indices are not able to detect the small treatment effects on segmental myocardial function which may have prognostic implications for cardiac events. We aimed to test the efficacy of allogeneic cardiosphere-derived cells (CDCs) for improving regional myocardial function and contractility.MethodsIn this exploratory analysis of a randomised clinical trial, 142 patients with post-MI with LVEF <45% and 15% or greater LV scar size were randomised in 2:1 ratio to receive intracoronary infusion of allogenic CDCs or placebo, respectively. Change in segmental myocardial circumferential strain (Ecc) by MRI from baseline to 6 months was compared between CDCs and placebo groups.ResultsIn total, 124 patients completed the 6-month follow-up (mean (SD) age 54.3 (10.8) and 108 (87.1%) men). Segmental Ecc improvement was significantly greater in patients receiving CDC (−0.5% (4.0)) compared with placebo (0.2% (3.7), p=0.05). The greatest benefit for improvement in segmental Ecc was observed in segments containing scar tissue (change in segmental Ecc of −0.7% (3.5) in patients receiving CDC vs 0.04% (3.7) in the placebo group, p=0.04).ConclusionsIn patients with post-MI LV dysfunction, CDC administration resulted in improved segmental myocardial function. Our findings highlight the importance of segmental myocardial function indices as an endpoint in future clinical trials of patients with post-MI.Trial registration numberNCT01458405.

The influence of cognitive behavioral intervention for anger management on endothelial function in patients with recent myocardial infarction

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Karine Elisa Schwarzer Schmidt ◽  
Alexandre Schaan de Quadros ◽  
Bruna Eibel ◽  
Aline Marques Aires ◽  
Carlos Antônio Mascia Gottschall ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Endothelial Function ◽  
Behavioral Intervention ◽  
Anger Management ◽  
Cognitive Behavioral ◽  
Cognitive Behavioral Intervention ◽  
Recent Myocardial Infarction

P850Clinical difference of recent myocardial infarction compared with acute myocardial infarction - Insights from Tokyo CCU network multicenter registry

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
R Ito ◽  
M Takayama ◽  
J Yamashita ◽  
K Yahagi ◽  
T Shinke ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiogenic Shock ◽  
Cause Of Death ◽  
Rank Test ◽  
Mechanical Complication ◽  
Recent Myocardial Infarction ◽  
Log Rank Test ◽  
Kaplan Meier ◽  
Multicenter Registry

Abstract Background Although the patient's characteristics and outcome of acute myocardial infarction (AMI) have been sufficiently investigated and primary percutaneous coronary intervention (PCI) has been recognized as established treatment strategy, those of recent myocardial infarction (RMI) have not been fully evaluated. Purpose The purpose of the present study was to clarify clinical characteristics and in-hospital outcomes of RMI patients from the database of the Tokyo CCU network multicenter registry. Methods In Tokyo CCU network multicenter registry database from 2013 to 2016, 15788 consecutive patients were registered as AMI (within 24 hours from onset) and RMI (within 2–30 days from onset). However 1246 patients were excluded because of inadequate data. And we excluded 66 cases because of out of onset period and 129 cases that strongly suspected of involvement of vasospastic events. Therefore, remaining 14347 patients were categorized to RMI group (n=1853) and AMI group (n=12494), and analyzed. Results Compared with AMI group, average age was older (70.4±12.9 vs 68.0±13.4 years, p<0.001), male was less (72.4 vs 76.4%, p<0.001), chest pain as chief complaint was less (75.2 vs 83.6%, p<0.001), prevalence of diabetes mellitus was higher (35.9 vs 31.0%, p<0.001), multi-vessel coronary disease was more (54.7 vs 44.6%, p<0.001), patients undergoing PCI was less (79.0 vs 91.2%, p<0.001), and the incidence of mechanical complication was more in RMI group (3.0 vs 1.5%, p<0.001). Although 30-day mortality was equivalent between 2 groups (5.3 vs 5.8%, p=0.360), the major cause of death in AMI group was cardiogenic shock, while in the RMI group it was a mechanical complication. On Kaplan-Meier analysis, the 2 groups had significantly different cumulative incidence of death due to cardiogenic shock (p=0.006, Log-rank test) and mechanical complication (p=0.021, Log-rank test). Furthermore death due to mechanical complication in AMI group was plateau after about 1 week from hospitalization, whereas in RMI group it continued to increase. Kaplan-Meier analysis Conclusions RMI patients had distinctive clinical features in backgrounds and treatment strategies compared with AMI patients, and the major cause of death of RMI patients was different from that of AMI patients. Furthermore, even though treatment during hospitalization of RMI patients was well done, death due to mechanical complications continued to increase.

Cardio-Protection by Ginkgo biloba Extract 50 in Rats with Acute Myocardial Infarction is Related to Na+–Ca2+ Exchanger

2013 ◽  
Vol 41 (04) ◽  
pp. 789-800 ◽  
Author(s):  
Ai-Hua Liu ◽  
Yi-Min Bao ◽  
Xing-Yu Wang ◽  
Zhi-Xiong Zhang
Keyword(s):  
Myocardial Infarction ◽  
At Risk ◽  
Ginkgo Biloba ◽  
Myocardial Function ◽  
Contractile Function ◽  
Salvia Miltiorrhiza ◽  
Ginkgo Biloba Extract ◽  
Area At Risk ◽  
Ischemia Group ◽  
Cardio Protection

Ginkgo biloba has been used for medical purposes for centuries in traditional Chinese medicine. Ginkgo biloba extract 50 (GBE50) is a new standardized GBE product that matches the standardized German product as EGb761. This paper is aimed at studying the cardio-protection effects of GBE50 Salvia miltiorrhiza on myocardial function, area at risk, myocardial ultra-structure, and expression of calcium handling proteins in rat ischemic myocardium. Myocardium ischemia was induced by the left anterior descending (LAD) coronary artery occlusion and myocardial function was recorded by a transducer advanced into the left ventricle on a computer system. In vitro myocardial infarction was measured by 2,3,5-triphenyltetrazolium chloride (TTC) and Evans blue staining of heart sections. Morphological change was evaluated by electric microscopy and Western blotting was used for protein expression. Hemodynamic experiments in vivo showed that postischemic cardiac contractile function was reduced in ischemic rats. Salvia miltiorrhiza (7.5 g/kg/d×7) and Ginkgo biloba extract 50 (GBE50) (100 mg/kg/d×7) improved post-schemic cardiac diastolic dysfunction while not affecting the systolic function. In hearts of GBE50 group and Salvia miltiorrhiza (SM) group, the area at risk was significantly reduced and myocardial structure was better-preserved. Moreover, Na +– Ca 2+ exchanger (NCX) expression increase and sarcoplasmic reticulum Ca 2+– ATPase 2 (SERCA2), LTCC, and ryanodine receptor 2 (RyR2) expression decreases were smaller than those in ischemia group. There was a significant difference between the GBE50 and ischemia group in NCX expression. GBE50 could improve recovery in contractile function and prevent myocardium from ischemia damage, which may be caused by attenuating the abnormal expression of NCX.

scholarly journals Recent myocardial infarction patients present ventilatory limitation during aerobic exercise

2012 ◽  
Vol 161 (3) ◽  
pp. 180-181 ◽  
Author(s):  
Marlus Karsten ◽  
Laura Maria Tomazi Neves ◽  
Victor Ribeiro Neves ◽  
Thomas Beltrame ◽  
Audrey Borghi-Silva ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Aerobic Exercise ◽  
Recent Myocardial Infarction ◽  
Ventilatory Limitation
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