scholarly journals Protein Interaction-Targeted Drug Discovery: Evaluating Critical Issues

BioTechniques ◽  
2002 ◽  
Vol 32 (3) ◽  
pp. 636-647 ◽  
Author(s):  
Erica A. Golemis ◽  
Kenneth D. Tew ◽  
Disha Dadke
Keyword(s):  
Drug Discovery ◽  
Protein Interaction ◽  
Critical Issues ◽  
Targeted Drug ◽  
Targeted Drug Discovery

Novel Technology for Protein-Protein Interaction-based Targeted Drug Discovery

2011 ◽  
Vol 2 (Supplement A) ◽  
pp. A61-A65 ◽  
Author(s):  
Jung Me Hwang ◽  
Kyung-Bok Lee ◽  
Jong-Soon Choi ◽  
Jaerang Rho ◽  
Gun-Hwa Kim ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Protein Interaction ◽  
Protein Protein Interaction ◽  
Novel Technology ◽  
Targeted Drug ◽  
Targeted Drug Discovery

Protein Interaction-Targeted Drug Discovery

2005 ◽  
pp. 323-345
Author(s):  
Gary Hudes ◽  
Sanjay Menon ◽  
Erica A. Golemis
Keyword(s):  
Drug Discovery ◽  
Protein Interaction ◽  
Targeted Drug ◽  
Targeted Drug Discovery

Natural products used as a chemical library for protein–protein interaction targeted drug discovery

2018 ◽  
Vol 79 ◽  
pp. 46-58 ◽  
Author(s):  
Xuemei Jin ◽  
Kyungro Lee ◽  
Nam Hee Kim ◽  
Hyun Sil Kim ◽  
Jong In Yook ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Protein Interaction ◽  
Chemical Library ◽  
Protein Protein Interaction ◽  
Targeted Drug ◽  
Targeted Drug Discovery

scholarly journals Novel Insights of Structure-Based Modeling for RNA-Targeted Drug Discovery

2012 ◽  
Vol 52 (10) ◽  
pp. 2741-2753 ◽  
Author(s):  
Lu Chen ◽  
George A. Calin ◽  
Shuxing Zhang
Keyword(s):  
Drug Discovery ◽  
Targeted Drug ◽  
Targeted Drug Discovery

scholarly journals Artificial intelligence and big data facilitated targeted drug discovery

2019 ◽  
Vol 4 (4) ◽  
pp. 206-213 ◽  
Author(s):  
Benquan Liu ◽  
Huiqin He ◽  
Hongyi Luo ◽  
Tingting Zhang ◽  
Jingwei Jiang
Keyword(s):  
Artificial Intelligence ◽  
Big Data ◽  
Drug Discovery ◽  
Three Dimensional ◽  
Data Bank ◽  
The Cancer Genome Atlas ◽  
Biological Databases ◽  
Cancer Genome Atlas ◽  
Targeted Drug ◽  
Targeted Drug Discovery

Different kinds of biological databases publicly available nowadays provide us a goldmine of multidiscipline big data. The Cancer Genome Atlas is a cancer database including detailed information of many patients with cancer. DrugBank is a database including detailed information of approved, investigational and withdrawn drugs, as well as other nutraceutical and metabolite structures. PubChem is a chemical compound database including all commercially available compounds as well as other synthesisable compounds. Protein Data Bank is a crystal structure database including X-ray, cryo-EM and nuclear magnetic resonance protein three-dimensional structures as well as their ligands. On the other hand, artificial intelligence (AI) is playing an important role in the drug discovery progress. The integration of such big data and AI is making a great difference in the discovery of novel targeted drug. In this review, we focus on the currently available advanced methods for the discovery of highly effective lead compounds with great absorption, distribution, metabolism, excretion and toxicity properties.

Splice variants in the proteome: a promising and challenging field to targeted drug discovery

2015 ◽  
Vol 20 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Raphael Tavares ◽  
Nicole M. Scherer ◽  
Carlos G. Ferreira ◽  
Fabricio F. Costa ◽  
Fabio Passetti
Keyword(s):  
Drug Discovery ◽  
Splice Variants ◽  
Targeted Drug ◽  
Targeted Drug Discovery

Abstract 1344: HMGA2-targeted drug discovery for breast cancer brain metastasis

2011 ◽  
Author(s):  
Riesa Burnett ◽  
Hitesh Appaiah ◽  
Poornima Bhat-Nakshatri ◽  
Jim Wikel ◽  
Peter Crooks ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Discovery ◽  
Brain Metastasis ◽  
Breast Cancer Brain Metastasis ◽  
Targeted Drug ◽  
Targeted Drug Discovery

scholarly journals Targeted Drug Discovery for Pediatric Leukemia

2013 ◽  
Vol 3 ◽  
Author(s):  
Andrew D. Napper ◽  
Venita G. Watson
Keyword(s):  
Drug Discovery ◽  
Pediatric Leukemia ◽  
Targeted Drug ◽  
Targeted Drug Discovery
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