scholarly journals Competing Morbidities In Advanced Head And Neck Squamous Cell Carcinoma Concurrent Chemoradiotherapy: A Strong Implication Of A Multidisciplinary Team Approach

2019 ◽  
Vol Volume 11 ◽  
pp. 9771-9782
Author(s):  
Grazia Lazzari ◽  
Maria Assunta De Cillis ◽  
Giovanni Buccoliero ◽  
Giovanni Silvano
2008 ◽  
Vol 26 (15) ◽  
pp. 2489-2496 ◽  
Author(s):  
David M. Brizel ◽  
Barbara A. Murphy ◽  
David I. Rosenthal ◽  
Kishan J. Pandya ◽  
Stefan Glück ◽  
...  

Purpose Acute mucositis is a dose-limiting toxicity of concurrent chemoradiotherapy regimens for locally advanced head and neck cancer. Palifermin (a recombinant human keratinocyte growth factor; ΔN23-KGF) stimulates the proliferation and differentiation of mucosal epithelium to reduce mucositis in patients receiving intensive therapy for hematologic cancers. This study assessed the efficacy and safety of palifermin in patients receiving concurrent chemoradiotherapy for advanced head and neck squamous cell carcinoma. Patients and Methods In a phase II trial, standard radiotherapy was delivered in daily 2-Gy fractions to 70 Gy, or hyperfractionated radiotherapy was delivered in 1.25-Gy fractions twice daily to 72 Gy, over 7 weeks. Chemotherapy included cisplatin 20 mg/m2 for 4 days and continuous-infusion fluorouracil 1,000 mg/m2/d for 4 days on weeks 1 and 5 of irradiation. Patients were randomly assigned 2:1 to palifermin 60 μg/kg or placebo once weekly for 10 doses. A follow-up trial evaluated long-term survival. Results Sixty-seven patients received palifermin and 32 received placebo. The median duration of grade ≥ 2 mucositis was 6.5 and 8.1 weeks in the palifermin and placebo groups, respectively (P = .157). Palifermin appeared to reduce mucositis, dysphagia, and xerostomia during hyperfractionated radiotherapy (n = 40) but not standard radiation therapy (n = 59). Adverse events were similar between treatment groups. Palifermin did not alter tumor response or survival. Conclusion Ten once-weekly doses of palifermin at 60 μg/kg were well tolerated. Most patients completed treatment, but palifermin did not reduce the morbidity of concurrent chemotherapy and radiotherapy. Future studies should evaluate higher palifermin doses with longer and more standardized assessment of acute mucositis.


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