Role of intranasal fentanyl in breakthrough pain management in cancer patients

Breakthrough pain is a transitory flare of pain occurring in most cancer patients against a background of otherwise controlled persistent pain. Treatment of breakthrough pain is a challenging phenomenon. Oral transmucosal fentanyl citrate (OTFC; brand name Actiqm, Cephalon Inc., West Chester, PA), a new opioid formulation with a unique delivery system, reflects the characteristics of breakthrough pain (rapid onset of action and short duration), making it an effective treatment for cancer patients who already receive opioids and experience flares of pain. This review article aims to present the role of oral transmucosal fentanyl citrate in the management of breakthrough pain in cancer patients. In particular, it is going to discuss the synthesis, clinical pharmacology, pharmacokinetic and pharmacodynamic properties, toxicity, and clinical efficacy of this novel agent.

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The role of rapid onset fentanyl products in the management of breakthrough pain in cancer patients

Pharmacological Reports ◽

10.1016/j.pharep.2019.01.010 ◽

2019 ◽

Vol 71 (3) ◽

pp. 438-442 ◽

Cited By ~ 3

Author(s):

Joanna Brząkała ◽

Wojciech Leppert

Keyword(s):

Cancer Patients ◽

Breakthrough Pain ◽

Rapid Onset

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Breakthrough pain management using fentanyl buccal tablet (FBT) in combination with around-the-clock (ATC) opioids based on the efficacy and safety of FBT, and its relationship with ATC opioids: results from an open-label, multi-center study in Japanese cancer patients with detailed evaluation

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyu167 ◽

2014 ◽

Vol 45 (1) ◽

pp. 67-74 ◽

Cited By ~ 5

Author(s):

C. Takigawa ◽

F. Goto ◽

S. Tanda ◽

Y. Shima ◽

K. Yomiya ◽

...

Keyword(s):

Pain Management ◽

Cancer Patients ◽

Breakthrough Pain ◽

Efficacy And Safety ◽

Open Label ◽

Fentanyl Buccal Tablet ◽

Buccal Tablet ◽

Detailed Evaluation ◽

Multi Center Study ◽

Center Study

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The Role of Acupuncture in Cancer Supportive Care

The American Journal of Chinese Medicine ◽

10.1142/s0192415x12500176 ◽

2012 ◽

Vol 40 (02) ◽

pp. 219-229 ◽

Cited By ~ 24

Author(s):

Jaung-Geng Lin ◽

Yi-Hung Chen

Keyword(s):

Head And Neck Cancer ◽

Chest Pain ◽

Pain Management ◽

Side Effects ◽

Head And Neck ◽

Cancer Patients ◽

Cancer Pain Management ◽

Beneficial Effects ◽

Proven Efficacy

Acupuncture has many beneficial effects during cancer therapy and has proven efficacy in the management of side effects induced by chemotherapy and radiotherapy. In this review, we discussed the benefits of acupuncture on cancer patients. In cancer pain management, acupuncture is effective for head and neck pain, waist pain, abdominal and chest pain. Many studies confirm the excellent efficacy of acupuncture against symptoms of vomiting and nausea, including those induced by chemotherapy and radiotherapy. Head and neck cancer patients receiving radiotherapy may develop xerostomia, which may be relieved by acupuncture. Acupuncture may also cause sedative and hypnotic effects in cancer patients for treating nervousness and insomnia.

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