scholarly journals Tiotropium inhibits methacholine-induced extracellular matrix production via β-catenin signaling in human airway smooth muscle cells

2018 ◽  
Vol Volume 13 ◽  
pp. 1469-1481 ◽  
Author(s):  
Yating Huo ◽  
Lili Guan ◽  
Jiawen Xu ◽  
Luqian Zhou ◽  
Rongchang Chen
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells ◽  
Beta Catenin ◽  
Human Airway Smooth Muscle ◽  
Extracellular Matrix Production ◽  
Matrix Production

Noncanonical WNT‐5A signaling regulates TGF‐β‐induced extracellular matrix production by airway smooth muscle cells

2012 ◽  
Vol 27 (4) ◽  
pp. 1631-1643 ◽  
Author(s):  
Kuldeep Kumawat ◽  
Mark H. Menzen ◽  
I. Sophie T. Bos ◽  
Hoeke A. Baarsma ◽  
Pieter Borger ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells ◽  
Extracellular Matrix Production ◽  
Matrix Production

Prostaglandins but not leukotrienes alter extracellular matrix protein deposition and cytokine release in primary human airway smooth muscle cells and fibroblasts

2012 ◽  
Vol 303 (3) ◽  
pp. L239-L250 ◽  
Author(s):  
David Van Ly ◽  
Janette K. Burgess ◽  
Thomas G. Brock ◽  
Tak H. Lee ◽  
Judith L. Black ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells ◽  
Cytokine Release ◽  
Human Airway Smooth Muscle ◽  
Tenascin C ◽  
Ecm Proteins

Eicosanoids are lipid-signaling mediators released by many cells in response to various stimuli. Increasing evidence suggests that eicosanoids such as leukotrienes and prostaglandins (PGs) may directly mediate remodeling. In this study, we assessed whether these substances could alter extracellular matrix (ECM) proteins and the inflammatory profiles of primary human airway smooth muscle cells (ASM) and fibroblasts. PGE2 decreased both fibronectin and tenascin C in fibroblasts but only fibronectin in ASM. PGD2 decreased both fibronectin and tenascin C in both ASM and fibroblasts, whereas PGF2α had no effect on ECM deposition. The selective PGI2 analog, MRE-269, decreased fibronectin but not tenascin C in both cell types. All the PGs increased IL-6 and IL-8 release in a dose-dependent manner in ASM and fibroblasts. Changes in ECM deposition and cytokine release induced by prostaglandins in both ASM and fibroblasts were independent of an effect on cell number. Neither the acute nor repeated stimulation with leukotrienes had an effect on the deposition of ECM proteins or cytokine release from ASM or fibroblasts. We concluded that, collectively, these results provide evidence that PGs may contribute to ECM remodeling to a greater extent than leukotrienes in airway cells.

Sign in / Sign up

Export Citation Format

Share Document