scholarly journals Bone Morphogenetic Protein-2 and Osteopontin Gene Expression in Epicardial Adipose Tissue from Patients with Coronary Artery Disease Is Associated with the Presence of Calcified Atherosclerotic Plaques

2020 ◽  
Vol Volume 13 ◽  
pp. 1943-1951
Author(s):  
María Luna-Luna ◽  
Sergio Criales-Vera ◽  
Diana Medina-Leyte ◽  
Mariana Díaz-Zamudio ◽  
Adriana Flores-Zapata ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Bone Morphogenetic Protein ◽  
Epicardial Adipose Tissue ◽  
Bone Morphogenetic Protein 2 ◽  
Atherosclerotic Plaques ◽  
Morphogenetic Protein ◽  
Artery Disease

scholarly journals Exploring the Role of Epicardial Adipose Tissue in Coronary Artery Disease From the Difference of Gene Expression

2021 ◽  
Vol 12 ◽  
Author(s):  
Qian-Chen Wang ◽  
Zhen-Yu Wang ◽  
Qian Xu ◽  
Ruo-Bing Li ◽  
Guo-Gang Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Epicardial Adipose Tissue ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Enrichment Analysis ◽  
Artery Disease

ObjectivesEpicardial adipose tissue (EAT) is closely adjacent to the coronary arteries and myocardium, its role as an endocrine organ to affect the pathophysiological processes of the coronary arteries and myocardium has been increasingly recognized. However, the specific gene expression profiles of EAT in coronary artery disease (CAD) has not been well characterized. Our aim was to investigate the role of EAT in CAD at the gene level.MethodsHere, we compared the histological and gene expression difference of EAT between CAD and non-CAD. We investigated the gene expression profiles in the EAT of patients with CAD through the high-throughput RNA sequencing. We performed bioinformatics analysis such as functional enrichment analysis and protein-protein interaction network construction to obtain and verify the hub differentially expressed genes (DEGs) in the EAT of CAD.ResultsOur results showed that the size of epicardial adipocytes in the CAD group was larger than in the control group. Our findings on the EAT gene expression profiles of CAD showed a total of 747 DEGs (fold change >2, p value <0.05). The enrichment analysis of DEGs showed that more pro-inflammatory and immunological genes and pathways were involved in CAD. Ten hub DEGs (GNG3, MCHR1, BDKRB1, MCHR2, CXCL8, CXCR5, CCR8, CCL4L1, TAS2R10, and TAS2R41) were identified.ConclusionEpicardial adipose tissue in CAD shows unique gene expression profiles and may act as key regulators in the CAD pathological process.

Extension of coronary artery disease is associated with increased IL-6 and decreased adiponectin gene expression in epicardial adipose tissue

Cytokine ◽  
2008 ◽  
Vol 43 (2) ◽  
pp. 174-180 ◽  
Author(s):  
Sonia Eiras ◽  
Elvis Teijeira-Fernández ◽  
Lilian Grigorian Shamagian ◽  
Angel Luis Fernandez ◽  
Angel Vazquez-Boquete ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Epicardial Adipose Tissue ◽  
Adiponectin Gene ◽  
Artery Disease

scholarly journals Pathogenic gene expression of epicardial adipose tissue in patients with coronary artery disease

2020 ◽  
Vol 151 (6) ◽  
pp. 554
Author(s):  
AnaghaVinay Sahasrabuddhe ◽  
ShaileshU Pitale ◽  
SaravanaDevi Sivanesan ◽  
PurushottamK Deshpande ◽  
SwapnilP Deshpande ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Epicardial Adipose Tissue ◽  
Artery Disease ◽  
Pathogenic Gene

scholarly journals FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

2021 ◽  
Vol 44 (4) ◽  
Author(s):  
Valentina V. Miroshnikova ◽  
Ekaterina A. Polyakova ◽  
Irina A. Pobozheva ◽  
Aleksandra A. Panteleeva ◽  
Natalia D. Razgildina ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Epicardial Adipose Tissue ◽  
Artery Disease

scholarly journals Subcutaneous and Epicardial Adipose Tissue Leptin Gene Expression in Coronary Artery Disease Patient

2019 ◽  
Vol 6 (3) ◽  
pp. 25-35
Author(s):  
E. A. Polyakova ◽  
D. A. Kolodina ◽  
V. V. Miroshnikova ◽  
N. D. Razgildina ◽  
E. O. Bogdanova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Coronary Artery Disease Patient ◽  
Epicardial Adipose Tissue ◽  
Disease Patient ◽  
Vascular Lesion ◽  
Lep Gene ◽  
Artery Disease

Objective. To assess the expression of the leptin gene (LEP) in the epicardial (EAT) and subcutaneous (SAT) adipose tissue in coronary artery disease (CAD) patients.Methods. 107 people were examined: 87 with CAD (57 men, 30 women), 20 without CAD (10 men, 10 women). Biopsy of EAT, SAT, coronary angiography, heart computed tomography, blood leptin levels were estimate, mRNA expression of the LEP gene evaluated by PCR.Results. In CAD patients with multivessel coronary artery lesion, the level of blood leptin is the highest. The expression of the LEP gene in EAT is higher in men than in women, in men with CAD higher than in non-coronary artery disease patients, and with a multivascular coronary lesion higher than in a 1–2 vascular lesion. Expression of the LEP gene in EAT in women with CAD is higher than with no CAD, and does not depend on the severity of coronary atherosclerosis. In SAT, LEP gene expression in men with CAD is higher than without CAD; women with CAD are lower than without CAD. Expression of the LEP gene in SAT is higher in men with a multivascular lesion than in 1–2 vascular lesion, and lower in women with a multivascular damage.Conclusions. The expression of the leptin gene in women is higher in SAT, and in men in EAT. Expression of the leptin gene in EAT with CAD is higher than without CAD. The expression of the leptin gene in SAT in men with CAD, especially with multivessel lesions, is higher than without coronary artery disease.

ABCA1 gene expression in epicardial adipose tissue of patients with coronary artery disease

2018 ◽  
Vol 275 ◽  
pp. e173
Author(s):  
V. Miroshnikova ◽  
A. Panteleeva ◽  
I. Pobozheva ◽  
N. Razgildina ◽  
E. Polyakova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Epicardial Adipose Tissue ◽  
Abca1 Gene ◽  
Artery Disease

The Role of Epicardial Adipose Tissue Lymphocytes in Low-Grade Inflammation and Coronary Artery Disease

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 469-P
Author(s):  
MILOS MRAZ ◽  
ANNA CINKAJZLOVA ◽  
ZDENA LACINOVÁ ◽  
JANA KLOUCKOVA ◽  
HELENA KRATOCHVILOVA ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Epicardial Adipose Tissue ◽  
Low Grade ◽  
Artery Disease ◽  
Low Grade Inflammation

scholarly journals The Associations of Epicardial Adipose Tissue With Coronary Artery Disease and Coronary Atherosclerosis

2014 ◽  
Vol 55 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Se-Hong Kim ◽  
Ju-Hye Chung ◽  
Beom-June Kwon ◽  
Sang-Wook Song ◽  
Whan-Seok Choi
Keyword(s):  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Coronary Atherosclerosis ◽  
Epicardial Adipose Tissue ◽  
Artery Disease
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