scholarly journals Prognostic Factors Related to the Mortality Rate of Acute-on-Chronic Liver Failure Patients

2021 ◽  
Vol Volume 14 ◽  
pp. 2573-2580
Author(s):  
Jian Zhang ◽  
Junfeng Li ◽  
Yu Chen ◽  
Mei Ding ◽  
Zhongping Duan
Keyword(s):  
Prognostic Factors ◽  
Mortality Rate ◽  
Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure

164 EARLY IDENTIFICATION OF PROGNOSTIC FACTORS OF DEATH IN ACUTE-ON-CHRONIC LIVER FAILURE

2010 ◽  
Vol 52 ◽  
pp. S72
Author(s):  
A. Escorsell ◽  
F. Torres ◽  
I. Bookman ◽  
A. Mas ◽  
J. Rios ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Liver Failure ◽  
Early Identification ◽  
Chronic Liver ◽  
Chronic Liver Failure

scholarly journals Static and dynamic prognostic factors for hepatitis-B-related acute-on-chronic liver failure

2015 ◽  
Vol 21 (3) ◽  
pp. 232 ◽  
Author(s):  
Jung Min Ha ◽  
Won Sohn ◽  
Ju Yeon Cho ◽  
Jeung Hui Pyo ◽  
Kyu Choi ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Hepatitis B ◽  
Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure

scholarly journals The Short-Term Efficacy of Tenofovir Alafenamide (TAF) in Acute-On-Chronic Liver Failure: A Single Center Experience

2021 ◽  
Author(s):  
Zhiqin Li ◽  
Yang Liu ◽  
Jianxia Dong ◽  
Jingya Yan ◽  
Yushu Hu ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Liver Failure ◽  
Virologic Response ◽  
Hbv Dna ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Single Center Experience ◽  
Primary Endpoints ◽  
Tenofovir Alafenamide ◽  
Dna Reduction

Abstract Background and aims: Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) reduce hepatic events and death in patients with acute-on-chronic liver failure (ACLF), but the efficacy of Tenofovir alafenamide (TAF) is less well studied. We aimed to assess the effectiveness of TAF in hepatitis B virus (HBV) related ACLF.Methods: We analyzed 106 patients with HBV-ACLF received TAF (25mg/d), ETV(0.5mg/d) for 12 weeks. The primary endpoints were overall mortality and liver transplantation (LT) at week 12. Other determined factors of biochemical response, virologic response, mortality rate, and drug safety and side-effect were also evaluated.Results: At 4 weeks and 12 weeks, patients received TAF got significantly higher HBV-DNA reduction (P<0.001), higher rate of HBV-DNA undetectbility (P<0.001), lower HBV-DNA level (P<0.001). Lower CTP scores (P=0.003) at 4 weeks in TAF group, but CTP scores showed no difference in two groups at 12 weeks (P=1.143). Lower ALT levels in TAF group at week 4 and week 12 (P=0.023, P<0.0001). The mortality rate was lower in TAF group after 4 weeks treatment(P=0.038), but two group got similar mortality rate at week 8 and week 12. As for reason cause death in HBV-ACLF patients, we found that two group patients developed similar rates of liver-related complications (P>0.05).Conclusions: The antiviral efficacy of TAF was superior than ETV for the treatment of HBV-related ACLF. TAF therapy reduced 4-week mortality rate in patients with HBV-related ACLF.

scholarly journals Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Yusheng Jie ◽  
Jiao Gong ◽  
Cuicui Xiao ◽  
Shuguang Zhu ◽  
Wenying Zhou ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mortality Rate ◽  
Blood Cell ◽  
Liver Failure ◽  
White Blood Cell ◽  
Chronic Liver ◽  
Healthy Controls ◽  
Chronic Liver Failure ◽  
Time Activity ◽  
Cell Ratio

Background. Platelet to white blood cell ratio (PWR) was an independent prognostic predictor for outcomes in some diseases. However, the prognostic role of PWR is still unclear in patients with hepatitis B related acute-on-chronic liver failure (ACLF). In this study, we evaluated the clinical performances of PWR in predicting prognosis in HBV-related ACLF. Methods. A total of 530 subjects were recruited, including 97 healthy controls and 433 with HBV-related ACLF. Liver function, prothrombin time activity (PTA), international normalized ratio (INR), HBV DNA measurement, and routine hematological testing were performed at admission. Results. At baseline, PWR in patients with HBV-related ACLF (14.03 ± 7.17) was significantly decreased compared to those in healthy controls (39.16 ± 9.80). Reduced PWR values were clinically associated with the severity of liver disease and the increased mortality rate. Furthermore, PWR may be an inexpensive, easily accessible, and significant independent prognostic index for mortality on multivariate analysis (HR = 0.660, 95% CI: 0.438–0.996, p=0.048) as well as model for end-stage liver disease (MELD) score. Conclusions. The PWR values were markedly decreased in ACLF patients compared with healthy controls and associated with severe liver disease. Moreover, PWR was an independent prognostic indicator for the mortality rate in patients with ACLF. This investigation highlights that PWR comprised a useful biomarker for prediction of liver severity.

Sa1546 THE MORTALITY RATE OF ACUTE ON CHRONIC LIVER FAILURE IN SETTING OF ACUTE HEPATITIS A INFECTION, A RETROSPECTIVE STUDY FROM A TERTIARY MEDICAL CENTER.

2020 ◽  
Vol 158 (6) ◽  
pp. S-1328-S-1329
Author(s):  
Karim Benrajab ◽  
Elica Shokri ◽  
Saad Emhmed Ali ◽  
Leon Su ◽  
Abimbola Chris-Olaiya ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Mortality Rate ◽  
Liver Failure ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Medical Center ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Acute Hepatitis A

scholarly journals Value of Liver Regeneration in Predicting Short-Term Prognosis for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Xiaoping Wang ◽  
Mengying Sun ◽  
Xianjun Yang ◽  
Liucun Gao ◽  
Min Weng ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Hepatitis B ◽  
Liver Failure ◽  
Scoring System ◽  
Chronic Liver ◽  
Hepatic Regeneration ◽  
Chronic Liver Failure ◽  
Short Term ◽  
Term Survival ◽  
Hepatocyte Regeneration

Background and Aims. The value of hepatocyte regeneration in predicting the outcomes of hepatitis B-related acute-on-chronic liver failure (HBV-ACLF) is not fully assessed. The present study was aimed at establishing a novel scoring system to predict patients’ outcomes within 3 months by applying serological indicators of hepatic regeneration and liver injury. Methods. Patients with chronic hepatitis B who had a rapid deterioration were investigated. Patients were observed for 90 days, and the endpoint of follow-up was death or liver transplantation. Serum parameters were estimated on the diagnosis of acute-on-chronic liver failure (ACLF). Cox proportional hazard regression was used to identify independent prognostic factors and create a novel prognostic scoring system, and a receiver operating characteristic (ROC) curve was used to analyze the performance of the model. Results. A total of 308 patients with HBV-ACLF were incorporated and divided into the training cohort (n=206) and testing cohort (n=102) randomly. Creatine (Cre), age, total bilirubin (TBil), alpha-fetoprotein (AFP), and international normalized ratio (INR) were found to be independent prognostic factors. According to the results of Cox regression analysis, a new prognostic model (we named it the TACIA score) was calculated. The areas under ROC (AUROC) for the new model were 0.861 and 0.763 in the training and testing cohorts, respectively, and patients with lower TACIA scores (<4.34) would survive longer (P<0.001). Conclusions. A pertinent prognostic scoring system for patients with HBV-ACLF was established in our study, and the novel model could predict patients’ short-term survival effectively.

Sign in / Sign up

Export Citation Format

Share Document