scholarly journals Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

Hypoxia ◽  
2018 ◽  
Vol Volume 6 ◽  
pp. 57-71 ◽  
Author(s):  
Kerstin Lippl ◽  
Anna Boleininger ◽  
Michael McDonough ◽  
Martine I. Abboud ◽  
Hanna Tarhonskaya ◽  
...  
Keyword(s):  
Oxygen Sensing ◽  
Prolyl Hydroxylase ◽  
Trichoplax Adhaerens

scholarly journals Nitric Oxide Modulates Oxygen Sensing by Hypoxia-inducible Factor 1-dependent Induction of Prolyl Hydroxylase 2

2006 ◽  
Vol 282 (3) ◽  
pp. 1788-1796 ◽  
Author(s):  
Utta Berchner-Pfannschmidt ◽  
Hatice Yamac ◽  
Buena Trinidad ◽  
Joachim Fandrey
Keyword(s):  
Nitric Oxide ◽  
Oxygen Sensing ◽  
Hypoxia Inducible Factor ◽  
Prolyl Hydroxylase ◽  
Hypoxia Inducible Factor 1

scholarly journals Oxygen Sensing in Drosophila: Multiple Isoforms of the Prolyl Hydroxylase Fatiga Have Different Capacity to Regulate HIFα/Sima

PLoS ONE ◽  
2010 ◽  
Vol 5 (8) ◽  
pp. e12390 ◽  
Author(s):  
Julieta M. Acevedo ◽  
Lazaro Centanin ◽  
Andrés Dekanty ◽  
Pablo Wappner
Keyword(s):  
Oxygen Sensing ◽  
Prolyl Hydroxylase

scholarly journals Nuclear Oxygen Sensing: Induction of Endogenous Prolyl-hydroxylase 2 Activity by Hypoxia and Nitric Oxide

2008 ◽  
Vol 283 (46) ◽  
pp. 31745-31753 ◽  
Author(s):  
Utta Berchner-Pfannschmidt ◽  
Suzan Tug ◽  
Buena Trinidad ◽  
Felix Oehme ◽  
Hatice Yamac ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Oxygen Sensing ◽  
Prolyl Hydroxylase

Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes

2013 ◽  
Vol 38 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Brian W. Wong ◽  
Anna Kuchnio ◽  
Ulrike Bruning ◽  
Peter Carmeliet
Keyword(s):  
Oxygen Sensing ◽  
Prolyl Hydroxylase ◽  
Prolyl Hydroxylase Domain

scholarly journals Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

2006 ◽  
Vol 103 (26) ◽  
pp. 9814-9819 ◽  
Author(s):  
M. A. McDonough ◽  
V. Li ◽  
E. Flashman ◽  
R. Chowdhury ◽  
C. Mohr ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Oxygen Sensing ◽  
Hypoxia Inducible Factor ◽  
Prolyl Hydroxylase ◽  
Cellular Oxygen

Oxygen-sensing mechanisms in development and tissue repair

Development ◽  
2021 ◽  
Vol 148 (23) ◽  
Author(s):  
Yida Jiang ◽  
Li-Juan Duan ◽  
Guo-Hua Fong
Keyword(s):  
Clinical Relevance ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Oxygen Sensing ◽  
Hypoxia Inducible Factor ◽  
Prolyl Hydroxylase ◽  
Loss Of Function ◽  
Mouse Development ◽  
Α Subunits ◽  
Prolyl Hydroxylase Domain

ABSTRACT Under normoxia, hypoxia inducible factor (HIF) α subunits are hydroxylated by PHDs (prolyl hydroxylase domain proteins) and subsequently undergo polyubiquitylation and degradation. Normal embryogenesis occurs under hypoxia, which suppresses PHD activities and allows HIFα to stabilize and regulate development. In this Primer, we explain molecular mechanisms of the oxygen-sensing pathway, summarize HIF-regulated downstream events, discuss loss-of-function phenotypes primarily in mouse development, and highlight clinical relevance to angiogenesis and tissue repair.

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